92629-87-3
Chemical Structure
Dexnafenodone
Synonym(s): (S)-Nafenodone free base; LU-43706 free base
- No. CAS: 92629-87-3
- Formula:C20H23NO
- Molecular Weight:293.41
IUPAC Name: (S)-2-(2-(dimethylamino)ethyl)-2-phenyl-3,4-dihydronaphthalen-1(2H)-one
InChIKey: IOKKIRANVRFSAH-FQEVSTJZSA-N
SMILES: C(CN(C)C)[C@]1(C(=O)C=2C(CC1)=CC=CC2)C3=CC=CC=C3
Biological Activity: Dexnafenodone ((S)-Nafenodone free base; LU-43706 free base) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone inhibits the fast inward Na+ current and slow inward Ca2+ current in cardiomyocytes. Dexnafenodone inhibits voltage-gated and receptor-activated Ca2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca2+ stores, suppresses agonist-stimulated Ca2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone can be used in the research of depression[1][2].
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Dexnafenodone | Dexnafenodone ((S)-Nafenodone free base; LU-43706 free base) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone inhibits the fast inward Na+ current and slow inward Ca2+ current in cardiomyocytes. Dexnafenodone inhibits voltage-gated and receptor-activated Ca2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca2+ stores, suppresses agonist-stimulated Ca2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone can be used in the research of depression. | |||||||||||||||||||||
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- [1]. Pérez-Vizcaíno F, et al. Effects of (S)-nafenodone on 45Ca2+ fluxes and contractions in rat isolated vascular smooth muscle. European journal of pharmacology. 1993 Feb 23;232(1):105-11. [Content Brief]
- [2]. Pérez-Vizcaino F, et al. Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres. European journal of pharmacology. 1991 Jun 18;199(1):43-50. [Content Brief]
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