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paclitaxel derivative

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (6) ADC Payload (3) Amino Acid Derivatives (1) Apoptosis (1) Bacterial (2) Caspase (1) Dihydrofolate reductase (DHFR) (2) Drug Intermediate (1) Fluorescent Dye (3) Fungal (2) LDLR (1) Microtubule/Tubulin (12) NAMPT (1) Peptide-Drug Conjugates (PDCs) (1) Reference Standards (1) Transglutaminase (1) VEGFR (2)
By Research Areas:	Cancer (23) Infection (2) Neurological Disease (2)

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Targets Recommended: Drug Derivative

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4073

ANG1005 GRN1005; paclitaxel trevatide	Peptide-Drug Conjugates (PDCs) LDLR	Cancer
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .

HY-20584

10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside	Microtubule/Tubulin ADC Payload	Cancer
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

HY-164165

Paclitaxel-2′-succinate NHS ester	Microtubule/Tubulin Drug Derivative	Cancer
Paclitaxel-2′-succinate NHS ester is a paclitaxel derivative with a succinic acid linker, in which the carboxyl group is activated by the NHS ester. The NHS ester group is highly reactive toward amino or hydroxyl groups and can be used to conjugate with other molecules such as peptides, proteins, antibodies, enzymes or polymers. Paclitaxel-2′-succinate NHS ester can be used in the development of nanomedicines and in the study of cancer therapy .

HY-131010

Flutax-2 (5/6-mixture)	Fluorescent Dye Microtubule/Tubulin	Cancer
Flutax-2 (5/6-mixture) is an active fluorescent derivative of paclitaxel. Flutax-2 (5/6-mixture) binds to a polymerized α,β tubulin dimer. Excitation/emission wavelength: 496/524 nm. Paclitaxel, a diterpenoid secondary metabolite produced by Taxus species, can be used for the research of a variety of cancers .

HY-77572

7-Epi 10-desacetyl paclitaxel 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel	ADC Payload	Cancer
7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC₅₀ of 85 μM .

HY-162161

Flutax-2	Fluorescent Dye Microtubule/Tubulin	Cancer
Flutax-2 is an active fluorescent derivative of Paclitaxel (HY-B0015) that binds to polymerized αβ-tubulin dimers. Flutax-2 is applicable for imaging microtubules in live cells, isolated cytoskeletons and parasites (Ex/Em=496/526 nm) .

HY-128595

MT-4	Transglutaminase	Cancer
MT-4 is a derivative of a tissue transglutaminase (TG2) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel.

HY-107629

Flutax 1	Fluorescent Dye	Cancer
Flutax 1 is a fluorescent Paclitaxel (HY-B0015) derivative, which can be used for microtubule staining (Ex/Em = 495 nm/520 nm) .

HY-17664

Paclitaxel succinate sulfo-NHS ester 2’-Sulfo-NHS-succinyl-paclitaxel	Drug Derivative Microtubule/Tubulin	Cancer
Paclitaxel succinate sulfo-NHS ester is a derivative of Paclitaxel (HY-B0015). Paclitaxel succinate sulfo-NHS ester can be used for the research of cancer .

HY-164272

2'-O-TBDMS-Paclitaxel	Microtubule/Tubulin	Cancer
2'-O-TBDMS-Paclitaxel is a paclitaxel (HY-B0015) derivative which 2'-OH group is protected as a tert-butyldimethylsilyl (TBDMS) ether .

HY-77574

7-xylosyltaxol 7-Xylosylpaclitaxel; Taxol-7-xyloside	Microtubule/Tubulin	Cancer
7-Xylosyltaxol (Taxol-7-xyloside) is a derivative of Paclitaxel (HY-B0015) found in the bark of Taxus wallichiana var. mairei. 7-Xylosyltaxol inhibits the growth of various cancer cells. 7-Xylosyltaxol can be used in cancer-related research .

HY-N7776

7-Xylosyl-10-Deacetyltaxol B 7-xylosyl-10-Deacetylpaclitaxel B	Others	Cancer
7-Xylosyl-10-Deacetyltaxol B (7-xylosyl-10-Deacetylpaclitaxel B) is a paclitaxel derivative derived from T. cuspidate. 7-Xylosyl-10-Deacetyltaxol B has anti-tumor activity and inhibits the growth of S180 sarcoma .

HY-77572R

7-Epi 10-desacetyl paclitaxel (Standard) 7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epipaclitaxel (Standard)	ADC Payload Reference Standards	Cancer
7-Epi 10-desacetyl paclitaxel (Standard) is the analytical standard of 7-Epi 10-desacetyl paclitaxel. This product is intended for research and analytical applications. 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM .

HY-N2379

rel-(2R,3S)-3-Phenylisoserine methyl ester	Amino Acid Derivatives Drug Intermediate	Others
Rel-(2R,3S)-3-Phenylisoserine methyl ester is a derivative of serine. Rel-(2R,3S)-3-Phenylisoserine methyl ester can be used as a side chain of Paclitaxel (HY-B0015) .

HY-N7777

7-Xylosyl-10-Deacetyltaxol C 7-Xylosyl-10-Deacetylpaclitaxel C	Others	Cancer
7-Xylosyl-10-Deacetyltaxol C (7-Xylosyl-10-Deacetylpaclitaxel C) is a paclitaxel derivative derived from T. cuspidate. 7-Xylosyl-10-Deacetyltaxol C has anti-tumor activity and inhibits the growth of S180 sarcoma .

HY-155647

Microtubule stabilizing agent-1	Microtubule/Tubulin	Cancer
Microtubule stabilizing agent-1 (compound 3l) is a Paclitaxel derivative that efficiently promotes tubulin polymerization. Microtubule stabilizing agent-1 shows antitumor efficacy .

HY-16371

Ortataxel IDN 5109; BAY 59-8862	Microtubule/Tubulin	Cancer
Ortataxel (IDN 5109; BAY 59-8862) is a derivative of Paclitaxel (HY-B0015). Ortataxel exhibits activity against multiple drug-sensitive and resistant cancer cell lines .

HY-151458

VEGFR-2/DHFR-IN-1	VEGFR Bacterial Dihydrofolate reductase (DHFR) Fungal	Infection Cancer
VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC₅₀s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC₅₀ values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer .

HY-151459

VEGFR-2/DHFR-IN-2	VEGFR Bacterial Dihydrofolate reductase (DHFR) Fungal	Infection Cancer
VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC₅₀s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC₅₀ values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer .

HY-16457

Simotaxel MST 997	Microtubule/Tubulin Caspase Apoptosis	Cancer
Simotaxel (MST 997) is an orally active derivative of the taxane class. Simotaxel binds to β-tubulin and promotes tubulin polymerization (EC₅₀ = 0.9 μM), inhibits tubulin depolymerization, and causes cell cycle arrest at the G₂-M phase. Simotaxel disrupts the formation of the mitotic spindle and triggers the caspase-dependent apoptotic pathway (apoptosis). Simotaxel has inhibitory effects on Paclitaxel (HY-B0015) sensitive cell lines and overcomes drug resistance. Simotaxel can be used to study Paclitaxel / Docetaxel (HY-B0011) resistant solid tumors .

HY-W751162

3'-epi-Paclitaxel	Drug Derivative	Cancer
3'-epi-Paclitaxel is a derivative of Paclitaxel (HY-B0015) and can be used in cancer research .

HY-185269

2'-Deoxy-PTX	Microtubule/Tubulin Drug Derivative	Cancer
2'-Deoxy-PTX is a Paclitaxel (HY-B0015) derivative and microtubule assembly inducer. 2'-Deoxy-PTX binds to GMPcPP-stabilized microtubules, with a Ka_app of 0.50 × 10 ⁶ M ^-1. 2′-Deoxy-PTX induces Tubulin to assemble into normal microtubules. 2'-Deoxy-PTX can be used for the research of prostate cancer .

HY-N19845

2′,7-Diacetyltaxol	Drug Derivative	Neurological Disease Cancer
2′,7-Diacetyltaxol (Compound 3) is an acetylated derivative of Paclitaxel (HY-B0015) and a cytotoxic agent. 2′,7-Diacetyltaxol is isolated from the acetylated fraction of Taxus brevifolia Nutt. 2′,7-Diacetyltaxol exhibits anticancer activity against oral epidermoid carcinoma. 2′,7-Diacetyltaxol is applicable to the research of neurological diseases .

HY-179523

Carba1	Drug Derivative NAMPT Microtubule/Tubulin	Neurological Disease Cancer
Carba1 is a bifunctional Carbazole (HY-D0204) derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances NAD biosynthesis. Carba1 binds to colchicine site of tubulin, enhancing the anti-tumor effect of various chemotherapy drugs, such as Paclitaxel (HY-B0015). Carba1 exerts neuroprotective effect and can regulate cell energy metabolism. Carba1 can be used for the researches of cancer and chemotherapy-induced peripheral neuropathy (CIPN) .

Flutax-2 (5/6-mixture)	Fluorescent Dyes
Flutax-2 (5/6-mixture) is an active fluorescent derivative of paclitaxel. Flutax-2 (5/6-mixture) binds to a polymerized α,β tubulin dimer. Excitation/emission wavelength: 496/524 nm. Paclitaxel, a diterpenoid secondary metabolite produced by Taxus species, can be used for the research of a variety of cancers .

Flutax 1	Biochemical Assay Reagents
Flutax 1 is a fluorescent Paclitaxel (HY-B0015) derivative, which can be used for microtubule staining (Ex/Em = 495 nm/520 nm) .

Cat. No.	Product Name	Target	Research Area

HY-P4073

ANG1005 GRN1005; paclitaxel trevatide	Peptide-Drug Conjugates (PDCs) LDLR	Cancer
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .

10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside	Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Source Classification Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin ADC Payload
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

7-Epi 10-desacetyl paclitaxel 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel	Microorganisms Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Source Classification Cancer	ADC Payload
7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC₅₀ of 85 μM .

7-xylosyltaxol 7-Xylosylpaclitaxel; Taxol-7-xyloside	Structural Classification Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Source Classification Cancer	Microtubule/Tubulin
7-Xylosyltaxol (Taxol-7-xyloside) is a derivative of Paclitaxel (HY-B0015) found in the bark of Taxus wallichiana var. mairei. 7-Xylosyltaxol inhibits the growth of various cancer cells. 7-Xylosyltaxol can be used in cancer-related research .

7-Xylosyl-10-Deacetyltaxol B 7-xylosyl-10-Deacetylpaclitaxel B	Taxus cuspidata Siebold & Zucc. Terpenoids Taxaceae Diterpenoids Plants Source Classification	Others
7-Xylosyl-10-Deacetyltaxol B (7-xylosyl-10-Deacetylpaclitaxel B) is a paclitaxel derivative derived from T. cuspidate. 7-Xylosyl-10-Deacetyltaxol B has anti-tumor activity and inhibits the growth of S180 sarcoma .

7-Epi 10-desacetyl paclitaxel (Standard) 7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epipaclitaxel (Standard)	Structural Classification Microorganisms Terpenoids Taxaceae Diterpenoids Plants Taxus chinensis (Pilger) Rehd. Source Classification	ADC Payload Reference Standards
7-Epi 10-desacetyl paclitaxel (Standard) is the analytical standard of 7-Epi 10-desacetyl paclitaxel. This product is intended for research and analytical applications. 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM .

7-Xylosyl-10-Deacetyltaxol C 7-Xylosyl-10-Deacetylpaclitaxel C	Classification of Application Fields Taxus cuspidata Siebold & Zucc. Terpenoids Taxaceae Plants Disease Research Fields Cancer	Others
7-Xylosyl-10-Deacetyltaxol C (7-Xylosyl-10-Deacetylpaclitaxel C) is a paclitaxel derivative derived from T. cuspidate. 7-Xylosyl-10-Deacetyltaxol C has anti-tumor activity and inhibits the growth of S180 sarcoma .

2′,7-Diacetyltaxol	Structural Classification Natural Products Taxaceae Plants Taxus brevifolia Nutt. Source Classification	Drug Derivative
2′,7-Diacetyltaxol (Compound 3) is an acetylated derivative of Paclitaxel (HY-B0015) and a cytotoxic agent. 2′,7-Diacetyltaxol is isolated from the acetylated fraction of Taxus brevifolia Nutt. 2′,7-Diacetyltaxol exhibits anticancer activity against oral epidermoid carcinoma. 2′,7-Diacetyltaxol is applicable to the research of neurological diseases .

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paclitaxel derivative

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