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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
paclitaxel derivative
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "paclitaxel derivative" in MCE Product Catalog:
Cat. No.: HY-P4073
CAS No.: 1075214-55-9
Synonyms: GRN1005; paclitaxel trevatide
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Cat. No.: HY-20584
CAS No.: 90332-63-1
Synonyms: 10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside
Category:
Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.
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Cat. No.: HY-164165
CAS No.: 245110-80-9
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Paclitaxel-2′-succinate NHS ester is a paclitaxel derivative with a succinic acid linker, in which the carboxyl group is activated by the NHS ester. The NHS ester group is highly reactive toward amino or hydroxyl groups and can be used to conjugate with other molecules such as peptides, proteins, antibodies, enzymes or polymers. Paclitaxel-2′-succinate NHS ester can be used in the development of nanomedicines and in the study of cancer therapy .
Cat. No.: HY-131010
Purity: 88.82%
Cat. No.: HY-77572
CAS No.: 78454-17-8
Synonyms: 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel
Category:
Microorganisms Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.
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Cat. No.: HY-162161
CAS No.: 301844-13-3
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Flutax-2 is an active fluorescent derivative of Paclitaxel (HY-B0015) that binds to polymerized αβ-tubulin dimers. Flutax-2 is applicable for imaging microtubules in live cells, isolated cytoskeletons and parasites (Ex/Em=496/526 nm) .
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MT-4 is a derivative of a tissue transglutaminase (TG2) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel.
Cat. No.: HY-107629
CAS No.: 191930-58-2
Cat. No.: HY-17664
CAS No.: 192047-93-1
Synonyms: 2’-Sulfo-NHS-succinyl-paclitaxel
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Paclitaxel succinate sulfo-NHS ester is a derivative of Paclitaxel (HY-B0015). Paclitaxel succinate sulfo-NHS ester can be used for the research of cancer .
Cat. No.: HY-164272
CAS No.: 114655-02-6
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2'-O-TBDMS-Paclitaxel is a paclitaxel (HY-B0015) derivative which 2'-OH group is protected as a tert-butyldimethylsilyl (TBDMS) ether .
Cat. No.: HY-77574
CAS No.: 90332-66-4
Synonyms: 7-Xylosylpaclitaxel; Taxol-7-xyloside
Category:
Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.
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Cat. No.: HY-N7776
CAS No.: 90332-64-2
Synonyms: 7-xylosyl-10-Deacetylpaclitaxel B
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Cat. No.: HY-77572R
CAS No.: 78454-17-8
Synonyms: 7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epipaclitaxel (Standard)
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Cat. No.: HY-N2379
CAS No.: 131968-74-6
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Rel-(2R,3S)-3-Phenylisoserine methyl ester is a derivative of serine. Rel-(2R,3S)-3-Phenylisoserine methyl ester can be used as a side chain of Paclitaxel (HY-B0015) .
Cat. No.: HY-N7777
CAS No.: 90332-65-3
Synonyms: 7-Xylosyl-10-Deacetylpaclitaxel C
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Cat. No.: HY-155647
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Microtubule stabilizing agent-1 (compound 3l) is a Paclitaxel derivative that efficiently promotes tubulin polymerization. Microtubule stabilizing agent-1 shows antitumor efficacy .
Cat. No.: HY-16371
CAS No.: 186348-23-2
Synonyms: IDN 5109; BAY 59-8862
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Ortataxel (IDN 5109; BAY 59-8862) is a derivative of Paclitaxel (HY-B0015). Ortataxel exhibits activity against multiple drug-sensitive and resistant cancer cell lines .
Cat. No.: HY-151458
CAS No.: 2831498-15-6
VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer .
Cat. No.: HY-151459
CAS No.: 2831498-09-8
VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer .
Cat. No.: HY-16457
CAS No.: 791635-59-1
Synonyms: MST 997
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Simotaxel (MST 997) is an orally active derivative of the taxane class. Simotaxel binds to β-tubulin and promotes tubulin polymerization (EC₅₀ = 0.9 μM), inhibits tubulin depolymerization, and causes cell cycle arrest at the G₂-M phase. Simotaxel disrupts the formation of the mitotic spindle and triggers the caspase-dependent apoptotic pathway (apoptosis). Simotaxel has inhibitory effects on Paclitaxel (HY-B0015) sensitive cell lines and overcomes drug resistance. Simotaxel can be used to study Paclitaxel / Docetaxel (HY-B0011) resistant solid tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
