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Cat. No.: HY-77574

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7-xylosyltaxol

(Synonyms: 7-Xylosylpaclitaxel; Taxol-7-xyloside)

7-Xylosyltaxol (Taxol-7-xyloside) is a derivative of Paclitaxel (HY-B0015) found in the bark of Taxus wallichiana var. mairei. 7-Xylosyltaxol inhibits the growth of various cancer cells. 7-Xylosyltaxol can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 90332-66-4
Formula: C₅₂H₅₉NO₁₈
Molecular Weight:986.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

7-xylosyltaxol Chemical Structure

CAS No.: 90332-66-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.85 μM Compound: 9	Antiproliferative activity against human A2780 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A2780 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
A549	IC₅₀	0.39 μM Compound: 9	Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
A549	IC₅₀	0.92 μM Compound: 9	Antiproliferative activity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
HCT-8	IC₅₀	5.9 μM Compound: 9	Antiproliferative activity against human HCT8 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HCT8 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
HepG2	IC₅₀	1.2 μM Compound: 9	Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
MCF7	IC₅₀	0.16 μM Compound: 9	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
NIH3T3	IC₅₀	>25 μM Compound: 9	Antiproliferative activity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]
SW480	IC₅₀	5.6 μM Compound: 9	Antiproliferative activity against human SW480 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Antiproliferative activity against human SW480 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 25682561]

In Vitro

7-Xylosyltaxol (Compound 9) exhibits high activity against A549, A549/CDDP, MCF-7, A2780, HCT8, SW480, and HepG2 cancer cell lines, with IC₅₀ values ranging from 0.16 to 5.9 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 90332-66-4
Molecular Weight 986.02
Formula C₅₂H₅₉NO₁₈
SMILES

O=C(C1=CC=CC=C1)N[C@@H](C2=CC=CC=C2)[C@@H](O)C(O[C@@H]3C(C)=C([C@@H](OC(C)=O)C([C@@]4(C)[C@]([C@](OC(C)=O)(CO5)[C@@]5([H])C[C@@H]4O[C@@]6([H])[C@H](O)[C@@H](O)[C@H](O)CO6)([H])[C@@H]7OC(C8=CC=CC=C8)=O)=O)C(C)(C)[C@@]7(O)C3)=O
Synonyms

7-Xylosylpaclitaxel; Taxol-7-xyloside
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun ZH, et al. Isolation and cytotoxicity evaluation of taxanes from the barks of Taxus wallichiana var. mairei. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1240-3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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