1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin

BNC105 

Cat. No.: HY-16114 Purity: 98.06%
Data Sheet SDS Handling Instructions

BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

For research use only. We do not sell to patients.
BNC105 Chemical Structure

BNC105 Chemical Structure

CAS No. : 945771-74-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $385 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. IC50 value: Target: BNC105 exhibited excellent potency against a panel of different cancer cell lines with IC50 <1 nM for DU145, Calu-6, MDA-MB-231 etc. The selectivity observed for BNC105 against activated over quiescent HUVECs was also observed in human aortic arterial endothelial cells (HAAECs). BNC105 also exhibited good potency toward the cisplatin resistant cell line A2780cis.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01034631 Hoosier Cancer Research Network|Bionomics Limited Renal Cell Carcinoma January 2010 Phase 1|Phase 2
NCT01624493 Hoosier Cancer Research Network|University of Sydney|Australia New Zealand Gynaecological Oncology Group|Bionomics Limited Ovarian Cancer October 2012 Phase 1|Phase 2
NCT01034631 Hoosier Cancer Research Network|Bionomics Limited Renal Cell Carcinoma January 2010 Phase 1|Phase 2
NCT01624493 Hoosier Cancer Research Network|University of Sydney|Australia New Zealand Gynaecological Oncology Group|Bionomics Limited Ovarian Cancer October 2012 Phase 1|Phase 2
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References
Molecular Weight

372.37

Formula

C₂₀H₂₀O₇

CAS No.

945771-74-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
BNC105
Cat. No.:
HY-16114
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