1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin

BNC105 (Synonyms: BNC-105)

Cat. No.: HY-16114
Handling Instructions

BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

For research use only. We do not sell to patients.
BNC105 Chemical Structure

BNC105 Chemical Structure

CAS No. : 945771-74-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $385 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. IC50 value: Target: BNC105 exhibited excellent potency against a panel of different cancer cell lines with IC50 <1 nM for DU145, Calu-6, MDA-MB-231 etc. The selectivity observed for BNC105 against activated over quiescent HUVECs was also observed in human aortic arterial endothelial cells (HAAECs). BNC105 also exhibited good potency toward the cisplatin resistant cell line A2780cis.

Clinical Trial
Sponsor Condition Start Date Phase
Hoosier Cancer Research Network Ovarian Cancer 2012-06-15 Phase 2
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.6855 mL 13.4275 mL 26.8550 mL
5 mM 0.5371 mL 2.6855 mL 5.3710 mL
10 mM 0.2686 mL 1.3428 mL 2.6855 mL
M.Wt

372.37

Formula

C₂₀H₂₀O₇

CAS No.

945771-74-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

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BNC105
Cat. No.:
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