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10-Deacetyl-7-xylosyl paclitaxel

HY-20584

(10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside)

10-Deacetyl-7-xylosyl paclitaxel

10-Deacetyl-7-xylosyl paclitaxel Chemical Structure

10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $88 In-stock
10 mg $80 In-stock
50 mg $220 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €86 In-stock
10 mg €78 In-stock
50 mg €216 In-stock
100 mg Get quote
200 mg Get quote

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Inquiry Information
Product name: 10-Deacetyl-7-xylosyl paclitaxel
Cat. No.: HY-20584

10-Deacetyl-7-xylosyl paclitaxel Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of 10-Deacetyl-7-xylosyl paclitaxel

10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility.
IC50 value:
Target: Microtubule inhibitor
10-Deacetyl-7-xylosyl paclitaxel induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9. In turn, caspase-9 activated downstream caspases-3 and -6, but not caspase-8. Bid was also activated by caspase-3. Reversely, treatment with a caspase-10-specific inhibitor could not protect PC-3 cells from 7-xylosyl-10-deacetyl-paclitaxel-triggered apoptosis. Moreover, 7-xylosyl-10-deacetylpaclitaxel had no effect on the expression of CD95 and NF-kappaB proteins, indicating that apoptosis was induced through the mitochondrial-dependent pathway in PC-3 cells.

Chemical Information

M.Wt 943.98 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₅₀H₅₇NO₁₇
CAS No 90332-63-1
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.0593 mL 5.2967 mL 10.5934 mL
5 mM 0.2119 mL 1.0593 mL 2.1187 mL
10 mM 0.1059 mL 0.5297 mL 1.0593 mL

References on 10-Deacetyl-7-xylosyl paclitaxel

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