Search Result

Results for "

passive cutaneous anaphylaxis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Calcium Channel (1) Calmodulin (1) Cholinesterase (ChE) (1) Drug Derivative (1) Glycosidase (1) Histamine Receptor (6) Interleukin Related (1) Phosphodiesterase (PDE) (3) Reference Standards (1) Syk (1) Tyrosinase (1)
By Research Areas:	Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (15) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1148

Furaltadone hydrochloride 1 Publications Verification Altafur hydrochloride	Bacterial	Infection Inflammation/Immunology
Furaltadone hydrochloride is an orally active antibacterial agent that can be used for the study of intestinal Salmonella infections. Furaltadone has in vitro inhibitory effects on Staphylococcus. In addition, Furaltadone shows inhibitory effects on allergic reactions .

HY-106358

Andolast free base CR 2039 free base; Dizolast free base	Phosphodiesterase (PDE)	Inflammation/Immunology
Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC₅₀ value of 50 μM. Andolast can be used for the research of asthma .

HY-106358A

Andolast CR 2039; Dizolast	Phosphodiesterase (PDE)	Inflammation/Immunology
Andolast (CR 2039) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC₅₀ value of 50 μM. Andolast can be used for the research of asthma .

HY-106645

Cloxacepride	Calmodulin	Neurological Disease Inflammation/Immunology
Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity .

HY-N5067

Rhodiocyanoside A Multifidin	Others	Inflammation/Immunology
Rhodiocyanoside A is found to show antiallergic activity in a passive cutaneous anaphylaxis test in rat .

HY-N10279

Gymconopin C	Others	Infection
Gymconopin C shows an antiallergic effect on ear passive cutaneous anaphylaxis reactions in mice.

HY-159926

Tixanox sodium RS-7540	Histamine Receptor	Inflammation/Immunology
Tixanox sodium (RS-7540), an anti-allergic compound, is a potent inhibitor of mediator release in the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction .

HY-W754020

Elbanizine	Histamine Receptor	Others
Elbanizine inhibits histamine, bradykinin, histamin-release from rat mast cells (IC₅₀ of 0.26 μM) and the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction. Elbanizine exhibits antiallergic and antiasthmatic in guinea pig model .

HY-106358R

Andolast free base (Standard) CR 2039 free base (Standard); Dizolast free base (Standard)	Reference Standards Phosphodiesterase (PDE)	Inflammation/Immunology
Andolast (free base) (Standard) is the analytical standard of Andolast (free base). This product is intended for research and analytical applications. Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma .

HY-126127

BRL 22321 free base	Histamine Receptor	Inflammation/Immunology
BRL 22321 free base is a stabilizer with similar mast cell stabilizing activity to Cromolyn sodium (HY-B0320A) and also has some smooth muscle relaxant activity. BRL 22321 free base is more potent than Cromolyn sodium (HY-B0320A) in inhibiting rat passive cutaneous and peritoneal anaphylaxis and antigen-induced histamine release from passively sensitized rat peritoneal cells .

HY-N4027

Hydrangenol 8-O-glucoside Hydrangenol 8-O-β-D-glucopyranoside	Cholinesterase (ChE)	Neurological Disease
Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be isolated from Hydrangea macrophyllu. Hydrangenol 8-O-glucoside is an AChE inhibitor (IC₅₀: 22.66 μM). Hydrangenol 8-O-glucoside inhibits passive cutaneous anaphylaxis (PCA) reaction .

HY-139247

pNPS-DHA	Drug Derivative	Inflammation/Immunology
pNPS-DHA (Compound 19) is an orally active DHA-ethanolamide (DHEA) derivative that has antiallergic activity. pNPS-DHA inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice. pNPS-DHA has anti-degranulating activity in RBL-2H3 mast cells with an IC₅₀ of 15 μM .

HY-N18182

Mudanpioside E	Glycosidase	Inflammation/Immunology
Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC₅₀ of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases .

HY-N19243

6-O-Senesioyl plenolin	Histamine Receptor	Inflammation/Immunology
6-O-Senesioyl plenolin is a sesquiterpene lactone found in Centipeda minima with antiallergic activity. 6-O-Senesioyl plenolin inhibits histamine release from mast cells (IC₅₀ = 18 μM) and suppresses pigment exudation in passive cutaneous anaphylaxis tests. 6-O-Senesioyl plenolin can be used in research related to allergy .

HY-183924

SYK-IN-14	Syk Tyrosinase	Inflammation/Immunology
SYK-IN-14 is an orally active Syk and ZAP-70 inhibitor with human Syk IC₅₀ of 0.006 μM, human ZAP-70 IC₅₀ of 0.23 μM. SYK-IN-14 functionally inhibits Syk kinase activity in vitro. SYK-IN-14 functionally inhibits ZAP-70 kinase activity in vitro. SYK-IN-14 suppresses passive cutaneous anaphylaxis reaction in Mus musculus mice. SYK-IN-14 suppresses Concanavalin A (HY-P2149)-induced IL-2 production in Mus musculus mice. SYK-IN-14 can be used for the research of allergic disorders and autoimmune diseases .

HY-107062

AA 344	Histamine Receptor	Inflammation/Immunology
AA 344 is an orally active antiallergic agent. AA 344 inhibits the IgE, IgGa, Concanavalin A (HY-P2149), Dextran -mediated release of histamine. AA 344 shows inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs. AA 344 selectively suppresses the type I allergic reaction .

HY-105594

Nivimedone BRL 10833 free base	Histamine Receptor	Inflammation/Immunology
Nivimedone (BRL 10833 free base) is an orally active antiallergic agent. Nivimedone inhibits IgE-mediated passive cutaneous anaphylaxis in rats. Nivimedone suppresses antigen-induced histamine release from lung tissues passively sensitized with atopic serum. Nivimedone can be used in research related to bronchial asthma .

HY-180165

Antiallergic agent-5	Calcium Channel Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Antiallergic agent-5 (Compound 4f) is an antiallergic agent. Antiallergic agent-5 suppresses Ca ²⁺ influx. Antiallergic agent-5 suppresses IgE/Ag-induced release of both IL-6 and TNF-α. Antiallergic agent-5 inhibits mast cell degranulation. Antiallergic agent-5 attenuates passive cutaneous anaphylaxis in mice and reduces vascular leakage .

Rhodiocyanoside A Multifidin	Natural Products Classification of Application Fields Crassulaceae Plants Rhodiola kirilowii (Regel) Maxim. Disease Research Fields Inflammation/Immunology Source Classification	Others
Rhodiocyanoside A is found to show antiallergic activity in a passive cutaneous anaphylaxis test in rat .

Gymconopin C	Infection other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
Gymconopin C shows an antiallergic effect on ear passive cutaneous anaphylaxis reactions in mice.

Hydrangenol 8-O-glucoside Hydrangenol 8-O-β-D-glucopyranoside	Hydrangeaceae Coumarins Phenylpropanoids Plants Source Classification	Cholinesterase (ChE)
Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be isolated from Hydrangea macrophyllu. Hydrangenol 8-O-glucoside is an AChE inhibitor (IC₅₀: 22.66 μM). Hydrangenol 8-O-glucoside inhibits passive cutaneous anaphylaxis (PCA) reaction .

Mudanpioside E	Structural Classification Monophenols Paeonia lactiflora Pall. Phenols Plants Paeoniaceae Source Classification	Glycosidase
Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC₅₀ of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases .

6-O-Senesioyl plenolin	Structural Classification Terpenoids Sesquiterpenes	Histamine Receptor
6-O-Senesioyl plenolin is a sesquiterpene lactone found in Centipeda minima with antiallergic activity. 6-O-Senesioyl plenolin inhibits histamine release from mast cells (IC₅₀ = 18 μM) and suppresses pigment exudation in passive cutaneous anaphylaxis tests. 6-O-Senesioyl plenolin can be used in research related to allergy .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

We use cookies

MedChemExpress values your privacy and your trust is important to us. We use cookies to enhance your website experience. Some cookies are necessary to run the website. Privacy and Cookie Policy

Name
Email *

	Sorry, but the email address you supplied was invalid.

passive cutaneous anaphylaxis

Inhibitors & Agonists

NaturalProducts

Natural
Products