50743-49-2
50743-49-2
Chemical Structure
AA 344
- CAS No.: 50743-49-2
- Formula:C12H10N4O2
- Molecular Weight:242.23
IUPAC Name: 6-ethyl-3-(1H-tetrazol-5-yl)-4H-chromen-4-one
InChIKey: UBEONZHRYRTJFN-UHFFFAOYSA-N
SMILES: O=C1C(C2=NN=NN2)=COC3=CC=C(CC)C=C13
Biological Activity: AA 344 is an orally active antiallergic agent. AA 344 inhibits the IgE, IgGa, Concanavalin A (HY-P2149), Dextran -mediated release of histamine. AA 344 shows inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs. AA 344 selectively suppresses the type I allergic reaction[1][2].
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AA 344 | AA 344 is an orally active antiallergic agent. AA 344 inhibits the IgE, IgGa, Concanavalin A (HY-P2149), Dextran -mediated release of histamine. AA 344 shows inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs. AA 344 selectively suppresses the type I allergic reaction. | |||||||||||||||||||||
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References
- [1]. Saijo T, et al. Inhibitory action of 6-ethyl-3-(1H-tetrazol-5-YL)chromone (AA-344) on IgE, IgGa- or chemical agent-induced histamine release from isolated rat mast cells. Jpn J Pharmacol. 1979 Aug;29(4):531-40. [Content Brief]
- [2]. Kuriki H, et al. Effect of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) on the immediate and delayed hypersensitivity reactions. Jpn J Pharmacol. 1979 Oct;29(5):733-44. [Content Brief]
