13 Results for "

pathological tau protein

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "pathological tau protein" in MCE Product Catalog:

Cat. No.: HY-P99471
CAS No.: 2244960-75-4
Synonyms: UCB 0107

Target:  

Tau Protein

Research Areas:  

Neurological Disease

Bepranemab is a humanized IgG4 monoclonal antibody that binds to the central region of tau protein. Bepranemab inhibits the seeding, aggregation of pathological tau protein and the spread of tau pathology to distal brain regions. Bepranemab is applicable to research related to Alzheimer's disease .
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Cat. No.: HY-P990995
CAS No.: 2690265-18-8
Synonyms: E2814

Target:  

Tau Protein

Research Areas:  

Neurological Disease

Etalanetug (E2814) is a humanized high-affinity IgG1 antibody that targets tau protein and can cross the blood-brain barrier. Etalanetug inhibits the spread of pathological tau protein through high-affinity binding to the microtubule-binding region (MTBR). Etalanetug can be used in research related to Alzheimer's disease .
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Cat. No.: HY-P99648
CAS No.: 1788032-39-2
Synonyms: BMS-986168; IPN007; BIIB092

Target:  

Tau Protein

Research Areas:  

Neurological Disease

Gosuranemab (BMS-986168; IPN007; BIIB092) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab neutralizes the extracellular tau protein, inhibiting the spread and aggregation of pathological tau protein. Gosuranemab can be used for the research of progressive supranuclear palsy and early Alzheimer’s disease .
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Cat. No.: HY-P9995
CAS No.: 2517973-04-3
Synonyms: JNJ-63733657

Target:  

Tau Protein

Research Areas:  

Neurological Disease

Posdinemab (JNJ-63733657) is a humanized IgG1/κ monoclonal antibody that selectively targets phosphorylated tau (pT217). Posdinemab specifically binds to the pT217+tau epitope rich in the proline domain, blocks tau protein aggregation and seed propagation, and promotes the clearance of extracellular tau species. Posdinemab reduces the levels of free and total p217+tau in cerebrospinal fluid, thereby inhibiting the pathological propagation of tau protein and the formation of neurofibrillary tangles. Posdinemab can be used for the study of progressive supranuclear palsy syndrome and Alzheimer's disease (AD), especially for prodromal or mild AD disease .
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Cat. No.: HY-P99164
CAS No.: 2019133-28-7
Synonyms: LY3303560

Target:  

Tau Protein

Research Areas:  

Neurological Disease

Zagotenemab (LY3303560) is a humanized anti-tau antibody that selectively binds and neutralises tau deposits in the brain. Zagotenemab can be used in Alzheimer's disease research .
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Cat. No.: HY-116753
CAS No.: 201529-58-0
Purity:  99.92%
(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD) .
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Cat. No.: HY-179492
CAS No.: 3033951-64-0
Target:  

hnRNP

Research Areas:  

Neurological Disease

ACI-19278 is a TDP-43 PET tracer with an average Kd of 25 nM. ACI-19278 only binds to pathological TDP-43 aggregates and does not cross-react with Aβ, Tau, etc. [ 18F]ACI-19278 successfully visualized the TDP-43 pathology in the human brain through positron emission computed tomography. ACI-19278 can be used for in vivo diagnosis of TDP-43 protein lesions .
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Cat. No.: HY-W835959
CAS No.: 2361566-66-5
Target:  

Tau Protein

Research Areas:  

Neurological Disease

ACI-3024 is an an orally active and highly selective Tau protein aggregation inhibitor. ACI-3024 decrease the β-sheet content and seeding properties of pathological Tau from different Tauopathies, leading to a significant rescue of the Tau-induced neurodegeneration and neuroinflammation in a cellular model. ACI-3024 is promising for research of neurodegenerative diseases .
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Cat. No.: HY-P2516
CAS No.: 330456-25-2
Target:  

Tau Protein

Research Areas:  

Neurological Disease

Tau Peptide (275-305) (Repeat 2 domain) is the Alzheimer's Tau fragment R2, corresponding to the second repeat unit of the microtubule-binding domain, which is believed to be pivotal to the biochemical properties of full tau protein. Tau Peptide (275-305) specifically coordinates with group IIB metal ions (Zn²⁺, Cd²⁺, Hg²⁺), which can induce their conformational changes and significantly promote their pathological accumulation. Tau Peptide (275-305) can be used to study the role of heavy metals in neurodegenerative diseases .
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Cat. No.: HY-P990995A
CAS No.: 2690265-18-8
Synonyms: 7G6 Antibody; 7G6-IgG2a

Target:  

Tau Protein

Research Areas:  

Neurological Disease

Etalanetug (Mouse IgG2a) (7G6 Antibody) is a mouse monoclonal antibody targeting the HVPGG motif in the microtubule-binding domain of tau protein. Etalanetug (Mouse IgG2a) reduces the levels of insoluble tau protein in multiple brain regions and inhibits the seeding and spread of pathological tau protein. Etalanetug (Mouse IgG2a) is applicable to research related to Alzheimer's disease .
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Cat. No.: HY-P992057

Target:  

Tau Protein

Research Areas:  

Neurological Disease

Armanezumab is a monoclonal antibody that targets and inhibits tau protein, and it specifically binds to the exposed N-terminal domain of pathological tau protein. Armanezumab can be used in relevant studies on Alzheimer's disease, frontotemporal dementia, and Pick's disease .
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Cat. No.: HY-P99648A
CAS No.: 1788032-39-2
Synonyms: BMS-986168 (powder); IPN007 (powder); BIIB092 (powder)

Target:  

Tau Protein

Research Areas:  

Neurological Disease

Gosuranemab (BMS-986168; IPN007; BIIB092) (powder) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab (powder) neutralizes the extracellular tau protein, inhibiting the spread and aggregation of pathological tau protein. Gosuranemab (powder) can be used for the research of progressive supranuclear palsy and early Alzheimer’s disease .
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Cat. No.: HY-P992172

Target:  

Tau Protein

Research Areas:  

Neurological Disease

ADEL-Y01 is a humanized and parental murine blood-brain barrier-penetrating monoclonal antibody against tau-acK280. ADEL-Y01 specifically recognizes tau-acK280 and its surrounding residues, mediates the neutralization and phagocytosis of acetylated tau aggregates, and interferes with the activity of pathological tau protein. ADEL-Y01 prevents the progression of tauopathies, increases neuronal survival rate, reduces tau-related pathological changes, and improves memory impairment. ADEL-Y01 can be used in research related to Alzheimer's disease and tauopathies .
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