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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
phosphodiesterase-III
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "phosphodiesterase-III" in MCE Product Catalog:
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1 Cited Publications
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Cat. No.: HY-B1294
CAS No.: 60719-84-8
Synonyms: Inamrinone
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Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .
Cat. No.: HY-B1639
CAS No.: 77671-31-9
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Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects .
Cat. No.: HY-19026
CAS No.: 115344-47-3
Synonyms: SKF 94836
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Siguazodan (SKF 94836) is a potent, selective and orally active phosphodiesterase III (PDE-III) inhibitor with an IC50 of 117 nM. Siguazodan increases cAMP accumulation in intact platelets with an EC50 of 18.88 μM. Siguazodan also inhibits phenylephrine-induced 5-HT release with an IC50 value of 4.2 μM .
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EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias .
Cat. No.: HY-101644A
CAS No.: 102685-83-6
Synonyms: BDF 8634 hydrochloride
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Saterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor.
Cat. No.: HY-P2424
CAS No.: 144396-38-3
Synonyms: CCK-J
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Cat. No.: HY-101644
CAS No.: 102669-89-6
Synonyms: BDF 8634
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Saterinone is a phosphodiesterase III (PDE III) inhibitor.
Cat. No.: HY-155165
CAS No.: 105622-85-3
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Dazonone is a phosphodiesterase III inhibitor with the IC50 of 1.68 μM .
Cat. No.: HY-U00136
CAS No.: 152633-54-0
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Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.
Synonyms: CI 914 free base
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Imazodan is a selective inhibitor for phosphodiesterase III (PDE III), which increases myocardial contractility by blocking the cAMP degradation, and improves the contractile function of heart. Imazodan serves also as a peripheral vasodilator .
Cat. No.: HY-113847
CAS No.: 102791-74-2
Synonyms: UK-61260-27
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Nanterinone mesylate (UK-61260-27) is an orally active and positive inotropic and balanced-type vasodilating agent, partially based on phosphodiesterase III inhibition with venodilating properties. Nanterinone mesylate is promising for research of cardiovascular diseases .
Cat. No.: HY-106045A
CAS No.: 89198-09-4
Synonyms: CI 914
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Imazodan hydrochloride is the hydrochloride form of Imazodan (HY-106045). Imazodan hydrochloride is a selective inhibitor for phosphodiesterase III (PDE III), which increases myocardial contractility by blocking the cAMP degradation, and improves the contractile function of heart. Imazodan hydrochloride serves also as a peripheral vasodilator .
Cat. No.: HY-16256
CAS No.: 75898-90-7
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Amrinone lactate is a positive inotropic-vasodilator agent. Amrinone lactate is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone lactate is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .
Cat. No.: HY-106098
CAS No.: 100510-33-6
Synonyms: BM 14478
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Adibendan (BM 14478), a benzimidazole derivative, is an orally active, selective phosphodiesterase III (PDE III) activity inhibitor (IC50=2.0 μM). Adibendan has IC50 values more than 60-fold higher for the inhibition of PDE I or II. Adibendan is a new cardiotonic agent .
Cat. No.: HY-B1294R
CAS No.: 60719-84-8
Synonyms: Inamrinone (Standard)
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Amrinone (Standard) is the analytical standard of Amrinone. This product is intended for research and analytical applications. Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .
Cat. No.: HY-19026R
CAS No.: 115344-47-3
Synonyms: SKF 94836 (Standard)
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Siguazodan (Standard) is the analytical standard of Siguazodan. This product is intended for research and analytical applications. Siguazodan (SKF 94836) is a potent, selective and orally active phosphodiesterase III (PDE-III) inhibitor with an IC50 of 117 nM. Siguazodan increases cAMP accumulation in intact platelets with an EC50 of 18.88 μM. Siguazodan also inhibits phenylephrine-induced 5-HT release with an IC50 value of 4.2 μM .
Cat. No.: HY-117181
CAS No.: 170684-14-7
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UK-1745 is a cardiotonic agent with vasodilating and antiarrhythmic properties. It increases intracellular levels of cyclic adenosine monophosphate (cAMP) in cardiomyocytes by inhibiting phosphodiesterase III, thereby enhancing myocardial contractility. Additionally, UK-1745 exhibits β-adrenergic receptor blocking activity, which helps reduce the oxygen consumption of the heart and prevent calcium overload. These characteristics make UK-1745 a promising candidate for research in congestive heart failure .
Cat. No.: HY-19088
CAS No.: 114856-44-9
Synonyms: CID-3047798
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Oberadilol (CID-3047798) is a Phosphodiesterase III inhibitor, non-selective β-adrenergic receptor blocker, vasodilator and positive inotropic agent. Oberadilol reduces left ventricular end-diastolic volume. Oberadilol is used in research related to chronic congestive heart failure and SARS-CoV-2 infection .
Cat. No.: HY-19088A
CAS No.: 114856-47-2
Synonyms: CID-3047798 (monoethyl maleate); TZC 5665
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Oberadilol monoethyl maleate (CID-3047798 monoethyl maleate) is a Phosphodiesterase III inhibitor, non-selective β-adrenergic receptor blocker, vasodilator and positive inotropic agent. Oberadilol monoethyl maleate reduces left ventricular end-diastolic volume. Oberadilol monoethyl maleate is used in research related to chronic congestive heart failure and SARS-CoV-2 infection .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
