84243-58-3
84243-58-3
Chemical Structure
Imazodan
Synonym(s): CI 914 free base
- CAS No.: 84243-58-3
- Formula:C13H12N4O
- Molecular Weight:240.26
IUPAC Name: 6-(4-(1H-imidazol-1-yl)phenyl)-4,5-dihydropyridazin-3(2H)-one
InChIKey: VXMYWVMXSWJFCV-UHFFFAOYSA-N
SMILES: O=C1CCC(C2=CC=C(N3C=CN=C3)C=C2)=NN1
Biological Activity: Imazodan is a selective inhibitor for phosphodiesterase III (PDE III), which increases myocardial contractility by blocking the cAMP degradation, and improves the contractile function of heart. Imazodan serves also as a peripheral vasodilator[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Imazodan | 99.38% | Imazodan is a selective inhibitor for phosphodiesterase III (PDE III), which increases myocardial contractility by blocking the cAMP degradation, and improves the contractile function of heart. Imazodan serves also as a peripheral vasodilator. | ||||||||||||||||||||
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Senazodan | Senazodan (MCI 154) is a Ca2+ sensitiser, and also shows inhibition effect on PDE III. | |||||||||||||||||||||
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Senazodan hydrochloride (Standard) | ≥98% | Senazodan (hydrochloride) (Standard) is the analytical standard of Senazodan (hydrochloride) (HY-101693A). This product is intended for research and analytical applications. Senazodan (MCI 154) (hydrochloride), as a Ca2+ sensitiser, shows inhibition effect on PDE III. | ||||||||||||||||||||
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Imazodan hydrochloride | Imazodan hydrochloride is the hydrochloride form of Imazodan (HY-106045). Imazodan hydrochloride is a selective inhibitor for phosphodiesterase III (PDE III), which increases myocardial contractility by blocking the cAMP degradation, and improves the contractile function of heart. Imazodan hydrochloride serves also as a peripheral vasodilator. | |||||||||||||||||||||
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Motapizone | 96.25% | Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP. | ||||||||||||||||||||
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B-Raf IN 8 | B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC50 of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC50 values of 9.78, 13.78, 18.52 and 29.85 µM. | |||||||||||||||||||||
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CI-930 | CI-930 is a selective, orally active phosphodiesterase 3 (PDE3) inhibitor with an IC50 value of 0.0.84 μM. CI-930 exerts positive inotropic and vasodilatory effects by inhibiting cAMP hydrolysis. CI-930 also regulates hemodynamics, inhibits the proliferation of coronary artery smooth muscle cells, and suppresses the proliferation of mouse splenocytes. CI-930 can be used in research related to heart failure, atherosclerosis, and asthma. | |||||||||||||||||||||
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Ozagrel methyl ester (Standard) | ≥98% | (E)-methyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)acrylate (Standard) is the analytical standard of (E)-methyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)acrylate. This product is intended for research and analytical applications. | ||||||||||||||||||||
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1,4-Di(1H-imidazol-1-yl)benzene | 1,4-Di(1H-imidazol-1-yl)benzene is a metal-organic framework (MOF). | |||||||||||||||||||||
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1-(Imidazol-1-yl)-4-(1,2,4-triazole-1-yl-methyl)benzene | 1-(Imidazol-1-yl)-4-(1,2,4-triazole-1-yl-methyl)benzene is a metal-organic framework (MOF). | |||||||||||||||||||||
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4'-(1H-Imidazol-1-yl)-[1,1'-biphenyl]-4-carboxylic acid | 4'-(1H-Imidazol-1-yl)-[1,1'-biphenyl]-4-carboxylic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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