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polymer degradation

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35

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1

Fluorescent Dyes

14

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1

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2

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Products

1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137677B
    GTPγS tetralithium

    Guanosine 5'-[γ-thio]triphosphate tetralithium

    		 GLUT Metabolic Disease
    GTPγS (Guanosine 5'-[γ-thio]triphosphate) tetralithium is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS tetralithium to couple with G- protein α, to study its effect on kinase activity. GTPγS tetralithium acts as a component of lysis buffer .
    GTPγS tetralithium
  • HY-108705
    BI-3802
    3 Publications Verification

    		 Molecular Glues Bcl-2 Family Cancer
    BI-3802, a chemical probe, is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity .
    BI-3802
  • HY-W723152
    Poly(D,L-lactide-co-glycolide)

    		Drug Intermediate Inflammation/Immunology
    Poly(D,L-lactide-co-glycolide) is a biodegradable polymer copolymer. Poly(D,L-lactide-co-glycolide) undergoes degradation through ester bond hydrolysis into lactic acid and glycolic acid. These two products can be naturally eliminated through metabolism in the body (such as the tricarboxylic acid cycle), without the risk of long-term accumulation. Poly(D,L-lactide-co-glycolide) can be used in medical sutures, implants, and drug delivery systems .
    Poly(D,L-lactide-co-glycolide)
  • HY-W250313
    Polylactic acid

    PLA

    		 Biochemical Assay Reagents Others Cancer
    Polylactic acid (PLA) is a biodegradable and biocompatible polymer widely used as a carrier for drug delivery systems and a structural material for tissue engineering and medical implants. Polylactic acid acts as a controlled release matrix through the hydrolysis mechanism of ester bonds, gradually releasing the encapsulated drug and metabolizing to non-toxic lactic acid. Polylactic acid has adjustable degradation rate, mechanical properties and the ability to composite with other polymers, and can be used in local or systemic drug delivery, orthopedic fixation devices and 3D printed bone regeneration scaffolds .
    Polylactic acid
  • HY-P1068
    Lysozyme
    Maximum Cited Publications
    8 Publications Verification

    Muramidase

    		 Bacterial TNF Receptor Interleukin Related TGF-β Receptor Infection Inflammation/Immunology
    Lysozyme (Muramidase) is a conserved antimicrobial protein. Lysozyme exerts its bactericidal effect by hydrolyzing bacterial cell wall peptidoglycan (PG). Lysozyme plays an important role in limiting bacterial growth on mucosal surfaces and other sites, not only controlling potential pathogens but also limiting overgrowth of microbiota to prevent dysbiosis. Extracellular lysozyme can also degrade polymeric PG into soluble fragments, activate NOD receptors in mucosal epithelial cells, and lead to the secretion of chemokines and activating factors by neutrophils and macrophages .
    Lysozyme
  • HY-P2875
    Hemicellulase

    		Endogenous Metabolite Others
    Hemicellulase is a hemicellulose-targeting hydrolase that breaks down the binding of glucose and polymers to water molecules present in plant fibers. Hemicellulase specifically degrades hemicellulose (such as xylan and mannan) in plant cell walls by hydrolyzing β-1,4-xylosidic bonds and ester bonds (such as acetyl and ferulic acid ester bonds). Hemicellulase relies on the synergistic action of the glycoside hydrolase (GH) and carbohydrate esterase (CE) families to achieve efficient hydrolysis through acid-base catalysis (such as Glu/Asp residues) and substrate binding pockets. Hemicellulase can be used in the food industry (such as improving bread texture)， biofuel production (lignocellulose pretreatment) and paper industry (biobleaching) .
    Hemicellulase
  • HY-112531B
    Poly(2-hydroxyethyl methacrylate) (Mv 300000)

    		Biochemical Assay Reagents Others
    Poly(2-hydroxyethyl methacrylate) (Mv 300000) is a biocompatible, optically transparent, hydrophilic, and non-degradable polymer with excellent cytocompatibility, eliciting a minimal immunological response from host tissue. Poly(2-hydroxyethyl methacrylate) (Mv 300000) can be used for different biomedical applications, such as bone tissue regeneration, wound dressings and drug delivery .
    Poly(2-hydroxyethyl methacrylate) (Mv 300000)
  • HY-W013021
    Norbornene

    		Ligands for E3 Ligase Others
    Norbornene is a cycloolefin and building block for synthesis of porous organic polymeric materials via metathesis, addition, and CANAL polymerization. Norbornene can also be used as an E3 ligase ligand for the synthesis of PROTAC, such as PROTAC HyTTD Degrader-1 (HY-181895) .
    Norbornene
  • HY-W105423
    Methacrylic acid N-hydroxysuccinimide ester

    NHS-MA

    		 Biochemical Assay Reagents Others
    Methacrylic acid N-hydroxysuccinimide ester (NHS-MA) is a polymer that serves as a monomer to prepare degradable amphiphilic block copolymer microparticles via RAFT polymerization for low pH-triggered drug delivery. Methacrylic acid N-hydroxysuccinimide ester is used for the synthesis of nanogels .
    Methacrylic acid N-hydroxysuccinimide ester
  • HY-W111581
    Copper(II) diethyldithiocarbamate
    1 Publications Verification

    Diethyldithiocarbamic acid copper salt

    		 Apoptosis Caspase Cancer
    Copper(II) diethyldithiocarbamate (Diethyldithiocarbamic acid copper salt) is a Copper(II) and diethyldithiocarbamate coordination polymer. Copper(II) diethyldithiocarbamate binds tightly to NPL4 and induces its aggregation, disrupting the p97-NPL4-UFD1 pathway. Copper(II) diethyldithiocarbamate causes ubiquitinated proteins accumulation and impairs waste proteins degradation, thus resulting in cell apoptosis. Copper(II) diethyldithiocarbamate inhibits tumor growth in MDA-MB-231 xenograft mice models. Copper(II) diethyldithiocarbamate can be used for the research of cancer, such as breast cancer .
    Copper(II) diethyldithiocarbamate
  • HY-139480
    Poly(ethylene glycol) dithiol (Mn 3400)

    		Biochemical Assay Reagents Others
    Poly(ethylene glycol) dithiol (Mn 3400) is a polymer and can be used as a biomaterial to prepare hydrogels .
    Poly(ethylene glycol) dithiol (Mn 3400)
  • HY-W099538
    Dilauryl thiodipropionate

    Dilauryl 3,3'-Thiodipropionate

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Dilauryl thiodipropionate (DLTDP), which is a sulfur-containing antioxidant commonly used to stabilize polymers and plastics against degradation caused by heat, oxygen, and UV light, acts to scavenge free radicals and others that may cause polymer chain scission and cross-linked active substances, in addition, DLTDP has been used as an additive to lubricants, oils and other industrial fluids to improve their oxidation stability, the long hydrocarbon chain in DLTDP makes it low volatility and compatible with many materials and Good compatibility with substrates.
    Dilauryl thiodipropionate
  • HY-154818
    Bovine Serum Albumin, Acetylated

    Ac-BSA

    		 Biochemical Assay Reagents Others
    Bovine Serum Albumin, Acetylated (Ac-BSA) is a polypeptide of known structure with strong antigenicity. Bovine Serum Albumin, Acetylated produced a significant immune response, validating the accuracy and reliability of the experimental method. Bovine Serum Albumin, Acetylated can be used as a positive control substance in ELISA or WB experiments, and can be used in experiments with acetylated lysine monoclonal or polyclonal antibodies. Bovine Serum Albumin, Acetylated also improves encapsulation efficiency at low concentrations of PLGA, a polymer for biopharmaceutical delivery with biocompatibility, degradability, and controlled release properties .
    Bovine Serum Albumin, Acetylated
  • HY-N13363
    2-Keto-3-deoxy-6-phosphogluconate

    		Fructose-1,6-bisphosphate aldolase Endogenous Metabolite Infection
    2-keto-3-deoxy-6-phosphogluconate is an endogenous metabolite found in Escherichia coli, and a key intermediate in the Entner-Doudoroff (ED) pathway, as well as in the degradation pathways of sugar acids and sugar polymers in human and plant pathogens. It is produced by the catalytic action of KDPG aldolase.
    2-Keto-3-deoxy-6-phosphogluconate
  • HY-15578G
    McMMAF

    Maleimidocaproyl monomethylauristatin F

    		 Drug-Linker Conjugates for ADC Cancer
    McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .
    McMMAF
  • HY-172383
    Polysuccinimide

    		Biochemical Assay Reagents Others
    Polysuccinimide, an amorphous polymer, is a polyimide precursor. Polysuccinimide can be used for the production of degradable polymers .
    Polysuccinimide
  • HY-162126
    Tubulin polymerization-IN-58

    		Microtubule/Tubulin YAP Cancer
    Tubulin polymerization-IN-58 (Compound K18) is a tubulin polymerization inhibitor with an IC50 of 0.446 μM. Tubulin polymerization-IN-58 also induces the degradation of oncogenic protein YAP via the UPS pathway, thus can be used for cancer research .
    Tubulin polymerization-IN-58
  • HY-155196
    ER degrader 6

    		Estrogen Receptor/ERR Cancer
    ER degrader 6 (compound 35s) is a potent Estrogen Receptor (ER)α degrader. ER degrader 6 disrupts the microtubule network by restraining tubulin polymerization. ER degrader 6 suppresses tumor growth without noticeable poisonousness .
    ER degrader 6
  • HY-W1048567E
    mPEG40000-SCM

    		Biochemical Assay Reagents Others
    mPEG40000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .
    mPEG40000-SCM
  • HY-W1048567A
    mPEG2000-SCM

    		Biochemical Assay Reagents Others
    mPEG2000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .
    mPEG2000-SCM
  • HY-W1048567H
    mPEG3400-SCM

    		Biochemical Assay Reagents Others
    mPEG3400-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .
    mPEG3400-SCM
  • HY-161641
    Tubulin polymerization-IN-62

    		Microtubule/Tubulin Cancer
    Tubulin polymerization-IN-62 (Compound 14b) is an inhibitor for microtubule polymerization (IC50 is 7.5 μM) and a degrader for α- and β-tubulin. Tubulin polymerization-IN-62 inhibits proliferation of cancer cells MCF-7, A549 and HCT-116, with IC50 of 32, 60 and 29 nM, respectively. Tubulin polymerization-IN-62 arrests the cell cycle at G2/M phase, inhibits the migration of MCF-7. Tubulin polymerization-IN-62 exhibits antitumor efficacy with a tumor growth inhibition rate (TGI) of 74.27% in 4T1 homograft mouse model .
    Tubulin polymerization-IN-62
  • HY-155197
    ER degrader 7

    		Microtubule/Tubulin Estrogen Receptor/ERR Cancer
    ER degrader 7 (Compound 35t) is an ERα and ERβ degrader. ER degrader 7 inhibits tubulin polymerization. ER degrader 7 inhibits cell viability with IC50s of 0.06, 2.56, 15.84, 1.59, 1.67, 1.37 μM for MCF-7, T47D, MCF-10A, LCC2, T47D D538G, and T47D Y537S cells respectively. ER degrader 7 also inhibits breast cancer tumor growth .
    ER degrader 7
  • HY-W099538R
    Dilauryl thiodipropionate (Standard)

    Dilauryl 3,3'-Thiodipropionate (Standard)

    		 Biochemical Assay Reagents Reference Standards Others
    Dilauryl thiodipropionate (Standard) is the analytical standard of Dilauryl thiodipropionate. This product is intended for research and analytical applications. Dilauryl thiodipropionate (DLTDP), which is a sulfur-containing antioxidant commonly used to stabilize polymers and plastics against degradation caused by heat, oxygen, and UV light, acts to scavenge free radicals and others that may cause polymer chain scission and cross-linked active substances, in addition, DLTDP has been used as an additive to lubricants, oils and other industrial fluids to improve their oxidation stability, the long hydrocarbon chain in DLTDP makes it low volatility and compatible with many materials and Good compatibility with substrates.
    Dilauryl thiodipropionate (Standard)
  • HY-W391671
    Poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine]

    		Endogenous Metabolite Biochemical Assay Reagents Others
    Poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] is a poly(triarylamine) that is an organic p-type semiconductor with hole mobilities ranging from 10 3 to 10 2 cm 2/V/s, which significantly improves carrier mobility. This stable, glassy polymer has an ionization potential suitable for thick film diodes. Committed to providing green alternatives that meet one or more of the 12 principles of green chemistry, this material falls into the enabling category of green alternatives, in line with the principle of "energy efficient design". In addition, while hole transport organic materials like these ensure optimal energy level alignment with the absorber layer for efficient charge collection, they can be susceptible to degradation under ambient conditions.
    Poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine]
  • HY-W1048567
    mPEG1000-SCM

    		Biochemical Assay Reagents Others
    mPEG1000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .
    mPEG1000-SCM
  • HY-W1048567B
    mPEG5000-SCM

    		Biochemical Assay Reagents Others
    mPEG5000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .
    mPEG5000-SCM
  • HY-W1048567D
    mPEG20000-SCM

    		Biochemical Assay Reagents Others
    mPEG20000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .
    mPEG20000-SCM
  • HY-W1048567C
    mPEG10000-SCM

    		Biochemical Assay Reagents Others
    mPEG10000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .
    mPEG10000-SCM
  • HY-179320
    mPEG-Amide-tri(DPCA)

    		Biochemical Assay Reagents Others
    mPEG-Amide-tri(DPCA) is a PEG-DPCA conjugate that can self-assemble into a supramolecular polymer hydrogel with nanofiber structures. mPEG-Amide-tri(DPCA) supramolecular polymer hydrogel exhibits shear-thinning behavior for injectable delivery, high drug loading, and degrades in vivo to release only DPCA and PEG. mPEG-Amide-tri(DPCA) supramolecular polymer hydrogel induces in vivo earhole regeneration in adult non-healing mice. mPEG-Amide-tri(DPCA) can be used for tissue regeneration research .
    mPEG-Amide-tri(DPCA)
  • HY-179313
    PEG-DPCA conjugate 1

    		Biochemical Assay Reagents Others
    PEG-DPCA conjugate 1 is a PEG-DPCA conjugate that can co-assemble with mPEG-Amide-tri(DPCA) (HY-179320) into a supramolecular polymer hydrogel with nanofiber structures. The supramolecular polymer hydrogel exhibits shear-thinning behavior for injectable delivery, high drug loading, and degrades in vivo to release only DPCA and PEG, induces in vivo earhole regeneration in adult non-healing mice. PEG-DPCA conjugate 1 can be used for tissue regeneration research .
    PEG-DPCA conjugate 1
  • HY-137677
    GTP-γ-S

    Guanosine 5'-[γ-thio]triphosphate

    		 GLUT Metabolic Disease
    GTPγS (Guanosine 5'-[γ-thio]triphosphate) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS to couple with G- protein α, to study its effect on kinase activity. GTPγS acts as a component of lysis buffer .
    GTP-γ-S
  • HY-108705R
    BI-3802 (Standard)

    		Molecular Glues Reference Standards Bcl-2 Family Cancer
    BI-3802 (Standard) is the analytical standard of BI-3802 (HY-108705). This product is intended for research and analytical applications. BI-3802, a chemical probe, is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity .
    BI-3802 (Standard)
  • HY-W583729
    DL-Polylactic acid

    		Biochemical Assay Reagents Others
    DL-Poly (lactic acid) is a biodegradable poly (α-hydroxy acid) matrix and a coating material for controlled drug release. DL-Poly (lactic acid) is classified as a drug release retardant, which degrades into natural lactic acid monomers, an intermediate product of carbohydrate metabolism, enabling complete drug delivery that lasts for several weeks. Its drug release rate is affected by the pH of the surrounding environment .
    DL-Polylactic acid
  • HY-P992382
    IC 100

    		Interleukin Related Neurological Disease Inflammation/Immunology
    IC 100 is a humanized IgG4κ monoclonal antibody targeting apoptosis-associated speck-like protein (ASC) with blood-brain barrier permeability. IC 100 specifically inhibits ASC after being endocytosed via its Fc segment, blocks ASC polymerization and inflammasome activation, suppresses IL-1β release, forms complexes with ASC and TRIM21, and evades TRIM21-mediated proteasomal degradation. IC 100 alleviates symptoms associated with autoimmune encephalomyelitis, reduces immune cell infiltration and microglial activation in the mouse EAE model. IC 100 is suitable for research on neuroinflammatory and inflammasome-related diseases such as multiple sclerosis. Isotype comparison: HY-P99003 .
    IC 100

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