645-15-8
Chemical Structure
Bis(4-nitrophenyl) phosphate
Synonym(s): BNPP
- CAS No.: 645-15-8
- Formula:C12H9N2O8P
- Molecular Weight:340.18
IUPAC Name: bis(4-nitrophenyl) hydrogen phosphate
InChIKey: MHSVUSZEHNVFKW-UHFFFAOYSA-N
SMILES: O=P(OC1=CC=C([N+]([O-])=O)C=C1)(OC2=CC=C([N+]([O-])=O)C=C2)O
Biological Activity: Bis(4-nitrophenyl) phosphate (BNPP) is an esterase inhibitor, inhibits the activity of esterases such as carboxylesterase. Bis(4-nitrophenyl) phosphate inhibits the degradation of Abiraterone in fresh plasma. Bis(4-nitrophenyl) phosphate can be used as a substrate to determine the enzymatic activity of phosphodiesterase in the roots of wetland plants. Bis(4-nitrophenyl) phosphate also acts as a catalyst for metallomicelles and a catalyst that promotes ring-opening polymerization (ROP)[1][2][3][4].
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Bis(4-nitrophenyl) phosphate | 99.93% | Bis(4-nitrophenyl) phosphate (BNPP) is an esterase inhibitor, inhibits the activity of esterases such as carboxylesterase. Bis(4-nitrophenyl) phosphate inhibits the degradation of Abiraterone in fresh plasma. Bis(4-nitrophenyl) phosphate can be used as a substrate to determine the enzymatic activity of phosphodiesterase in the roots of wetland plants. Bis(4-nitrophenyl) phosphate also acts as a catalyst for metallomicelles and a catalyst that promotes ring-opening polymerization (ROP). | ||||||||||||||||||||
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Bis(4-nitrophenyl) phosphate (Standard) | ≥98% | Bis(4-nitrophenyl) phosphate (Standard) is the analytical standard of Bis(4-nitrophenyl) phosphate. This product is intended for research and analytical applications. Bis(4-nitrophenyl) phosphate (BNPP) is an esterase inhibitor, inhibits the activity of esterases such as carboxylesterase. Bis(4-nitrophenyl) phosphate inhibits the degradation of Abiraterone in fresh plasma. Bis(4-nitrophenyl) phosphate can be used as a substrate to determine the enzymatic activity of phosphodiesterase in the roots of wetland plants. Bis(4-nitrophenyl) phosphate also acts as a catalyst for metallomicelles and a catalyst that promotes ring-opening polymerization (ROP). | ||||||||||||||||||||
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References
- [1]. Bruin MAC, et al. Stabilization of Abiraterone in Human Plasma Using the Esterase Inhibitor Bis(4-nitrophenyl) Phosphate. Therapeutic drug monitoring. 2025 Oct 01;47(5):686-690. [Content Brief]
- [2]. Xie, JQ., et al. Preparation of a new metallomicelle catalyst for the hydrolysis of bis(4-nitrophenyl) phosphate. Chem. Pap. 67, 365-371 (2013).
- [3]. Jun L, et al. Mechanism of intramolecular nucleophilic substitution in the catalytic hydrolysis of bis (4-nitrophenyl) phosphate ester in a metallomicelle. Progress in Reaction Kinetics and Mechanism. 2006 May;31(4):189-204.
- [4]. Makiguchi, K., et al. (2014), Bis(4-nitrophenyl) phosphate as an efficient organocatalyst for ring-opening polymerization of β-butyrolactone leading to end-functionalized and diblock polyesters. J. Polym. Sci. Part A: Polym. Chem., 52: 2032-2039.
