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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
presenilin
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "presenilin" in MCE Product Catalog:
Target:
Research Areas:
GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1) .
Cat. No.: HY-161723
CAS No.: 2358754-22-8
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LH2-051, a lysosome-enhancing compound (LYEC), is a brain-penetrant dopamine transporter (DAT) inhibitor (Ki: 0.95 μM). LH2-051 inhibits DAT-mediated dopamine uptake with an IC50 of 3.0 μM. LH2-051 promotes nuclear translocation of TFEB and lysosome biogenesis. LH2-051 improves the memory of amyloid precursor protein (APP)/Presenilin 1 (PS1) mice. LH2-051 can be used for the study of Alzheimer’s disease .
Cat. No.: HY-50882
CAS No.: 851600-86-7
Target:
Research Areas:
ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1 .
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Research Areas:
FRM-024 is a central nervous system-penetrant, orally active γ-secretase modulator and Aβ42 lowering agent. FRM-024 is used for the research of familial Alzheimer's disease .
Cat. No.: HY-50882A
CAS No.: 851599-82-1
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Research Areas:
ELN318463 racemate is the racemate of ELN318463. ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively. ELN318463 is 51-fold more selective for PS1 .
Cat. No.: HY-N7763
CAS No.: 79786-00-8
Category:
Target:
Cat. No.: HY-P3713
CAS No.: 956004-39-0
Cat. No.: HY-139052
CAS No.: 398515-96-3
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Research Areas:
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits Aऔ production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research .
Cat. No.: HY-P82123A
Synonyms: PSEN1; AD3; PS1; PSNL1; presenilin-1; PS-1; Protein S182
Cat. No.: HY-P992275
Target:
Research Areas:
Cat. No.: HY-P75691
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KCNIP3; Calsenilin, presenilin-Binding Protein, EF Hand Transcription Factor; Prev. CSEN; Kv Channel Interacting Protein 3, Calsenilin; KCHIP3; Kv Channel-Interacting Protein 3; DREAM; Potassium Channel Interacting Protein 3; DRE-Antagonist Modulator; KCh
Species:
Human
Source:
E. coli
Cat. No.: HY-P702211
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: APH1A; Aph-1alpha; Aph-1A Gamma-Secretase Subunit; APH-1; Aph-1 Homolog A, Gamma-Secretase Subunit; Anterior Pharynx Defective 1 Homolog A (C. Elegans); APH-1A; Anterior Pharynx Defective 1 Homolog A; CGI-78; Gamma-Secretase Subunit APH-1; presenilin-Stab
Species:
Human
Source:
E. coli Cell-free
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
