Presenilin 2 Antibody (YA1605)(PBS only)
(Synonyms: AD3LP; AD5; E5-1; STM-2)Presenilin 2 Antibody (YA1605) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Presenilin 2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:1000-1:5000 | 1:200-1:500 | 1:50-1:200 | 1:20-1:50 | 1:20 |
Product Details
Presenilin 2 Antibody (YA1605) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Presenilin 2.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 23 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 50 kDa
A synthetic peptide of human Presenilin 2
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Presenilin 2 is a Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria[1][2].
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Subcellular Localization
Endoplasmic reticulum membrane; Multi-pass membrane protein; Golgi apparatus membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Isomer 1 is found in the placenta, skeletal muscle, and heart, while isomer 2 is found in the heart, brain, placenta, liver, skeletal muscle, and kidneys. -
Isoforms & Post-Translational Modification
P49810 has 3 isomers: P49810-1: 50140 Da (predicted); P49810-2: 46387 Da (predicted); P49810-3: 50011 Da (predicted).
Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments;Phosphorylated on serine residues -
Subunit
Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with HERPUD1, FLNA, FLNB and PARL
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SwissProt ID
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Synonyms
AD3LP; AD5; E5-1; STM-2
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Research Field
Neuroscience
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