Presenilin 2 Antibody (YA1605)(PBS only)

Cat. No.: HY-P81860A: Data Sheet User Guide for Antibodies
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Presenilin 2 Antibody (YA1605) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Presenilin 2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Presenilin 2 Antibody (YA1605) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Presenilin 2.

Host

Rabbit

Molecular Weight

Predicted band size: 50 kDa;

Observed band size: 23 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P49810

Gene ID

5664 [NCBI]

Immunogen

A synthetic peptide of human Presenilin 2

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:5000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
FC FC: Flow Cytometry	1:20-1:50
IP IP: Immunoprecipitation	1:20

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369)

Subcellular Localization：Endoplasmic reticulum membrane; Multi-pass membrane protein; Golgi apparatus membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Isomer 1 is found in the placenta, skeletal muscle, and heart, while isomer 2 is found in the heart, brain, placenta, liver, skeletal muscle, and kidneys.

Isoforms & Post-Translational Modification：P49810 has 3 isomers: P49810-1: 50140 Da (predicted); P49810-2: 46387 Da (predicted); P49810-3: 50011 Da (predicted).
Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments;Phosphorylated on serine residues

Subunit：Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with HERPUD1, FLNA, FLNB and PARL

Research Field

Neuroscience

Synonyms

AD3LP; AD5; E5-1; STM-2

Documentation

User Guide for Antibodies (1077 KB)