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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
quinazolinone inhibitors
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "quinazolinone inhibitors" in MCE Product Catalog:
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2 Cited Publications
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NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues .
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1 Cited Publications
Cat. No.: HY-N2384
CAS No.: 24159-07-7
Category:
Infection Alkaloids Dichroa febrifuga Lour Pyridine Alkaloids Plants Saxifragaceae Disease Research Fields
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1
1 Cited Publications
Cat. No.: HY-N2384A
CAS No.: 32434-42-7
Category:
Infection Alkaloids Dichroa febrifuga Lour Pyridine Alkaloids Plants Saxifragaceae Disease Research Fields
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Cat. No.: HY-W005308
CAS No.: 69942-12-7
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Cat. No.: HY-W040417
CAS No.: 155905-77-4
Cat. No.: HY-179251
BDGR-651 is an efficient and selective inhibitor of the Chikungunya virus (CHIKV) with an EC50 in NHDF cells of 0.86 μM, and the therapeutic index (SI) of 22.1. BDGR-651 exhibits dose-dependent protective effects when infecting Vero E6 cells, with its EC50 being 6 μM. BDGR-651 can be used for research on CHIKV infection .
Cat. No.: HY-118316
CAS No.: 899758-61-3
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GSK223 is a quinazolinone NOD1 pathway inhibitor with potential anti-inflammatory activity. GSK223 can selectively inhibit IL-8 release under iE-DAP stimulation without affecting IL-8 secretion caused by TNF receptor, TLR2 or NOD2 agonists. GSK223 does not directly inhibit RIP2 kinase activity.
Cat. No.: HY-168260
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CQ-Mito is a Coumarin-Quinazolinone (CQ)-based derivative that targets mitochondria and exhibits profound phototherapeutic performances with an Phototoxic Index (PI) value of 167. CQ-Mito causes cell death by both apoptosis and ferroptosis. CQ-Mito mediates mitochondrial dysfunction, including mitochondrial morphology changed and the loss of MMP. CQ-Mito can efficiently inhibit the tumor growth in organoid tumor models .
Cat. No.: HY-181265
CAS No.: 3087853-45-7
PARP1-IN-53 (Compound 328) is a quinazolinone derivative and PARP1 inhibitor with a PARP1 IC50 of 0.1 nM and selectivity over PARP2, which has a PARP2 IC50 of 23 nM.PARP1-IN-53 can be used for the research of cancer .
Cat. No.: HY-103195R
CAS No.: 299442-43-6
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NKY80 (Standard) is the analytical standard of NKY80 (HY-103195). This product is intended for research and analytical applications. NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
