899758-61-3
899758-61-3
Chemical Structure
GSK223
- CAS No.: 899758-61-3
- Formula:C21H18FN3O3S2
- Molecular Weight:443.51
IUPAC Name: 5-ethyl-N-(2-fluoro-5-(2-methyl-4-oxoquinazolin-3(4H)-yl)phenyl)thiophene-2-sulfonamide
InChIKey: UFQKEYUIACWHNI-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(S1)CC)(NC2=CC(N3C(C)=NC4=C(C3=O)C=CC=C4)=CC=C2F)=O
Biological Activity: GSK223 is a quinazolinone NOD1 pathway inhibitor with potential anti-inflammatory activity. GSK223 can selectively inhibit IL-8 release under iE-DAP stimulation without affecting IL-8 secretion caused by TNF receptor, TLR2 or NOD2 agonists. GSK223 does not directly inhibit RIP2 kinase activity.
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GSK223 | GSK223 is a quinazolinone NOD1 pathway inhibitor with potential anti-inflammatory activity. GSK223 can selectively inhibit IL-8 release under iE-DAP stimulation without affecting IL-8 secretion caused by TNF receptor, TLR2 or NOD2 agonists. GSK223 does not directly inhibit RIP2 kinase activity. | |||||||||||||||||||||
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