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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
rat α4β2-nAChR
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "rat α4β2-nAChR" in MCE Product Catalog:
Synonyms: ABT-089 dihydrochloride
Target:
Research Areas:
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [ 3H]cytisine sites . Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant .
Synonyms: 5-I A-85380 dihydrochloride
Target:
Research Areas:
5-Iodo-A-85380 dihydrochloride is a selective ligand of nAChR. 5-Iodo-A-85380 dihydrochloride binds to α4β2 nAChRs in rat and human brain with Kds of 12 and 14 pM,respectively .
Cat. No.: HY-138953
CAS No.: 188895-96-7
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Research Areas:
Epiboxidine is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418 .
Cat. No.: HY-169742
CAS No.: 140111-52-0
Research Areas:
Epibatidine is a nicotinic acetylcholine receptor (nAChR) agonist, with an IC50 of 70 pM, a Ki of 43 pM for rat nAChR, a Kd range of 1.5-60 nM for human α7 nAChR, a Kd of 15 nM for rat α4β2 nAChR, and a Kd of 0.5 μM for rat α3β4 nAChR. Epibatidine selectively activates central nAChRs and binds to muscarinic acetylcholine receptors (mAChR). It is used in research on pain, Alzheimer's disease, Parkinson's disease, and schizophrenia-related pain .
Cat. No.: HY-14565
CAS No.: 161417-03-4
Synonyms: ABT-089
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Research Areas:
Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [ 3H] cytisine sites is 16.7 nM.
Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction .
Cat. No.: HY-138953A
CAS No.: 862909-67-9
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Research Areas:
Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418 .
Cat. No.: HY-110160R
CAS No.: 161416-61-1
Synonyms: ABT-089 dihydrochloride (Standard)
Target:
Research Areas:
Pozanicline dihydrochloride (Standard) is the analytical standard of Pozanicline (dihydrochloride) (HY-110160). This product is intended for research and analytical applications. Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites . Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant .
Cat. No.: HY-183666
CAS No.: 223796-90-5
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NS3956 is a blood-brain barrier-permeable human α4β2-nicotinic acetylcholine receptor (nAChR) agonist (Ki = 0.36 nM). NS3956 induces dopamine release, produces analgesic effects, modulates rotational behavior in 6-OHDA-lesioned rats, and potentiates the effects of SSRI/SNRI in the forced swim test in mice. NS3956 can be used in research related to depression, Parkinson's disease, and acute pain .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
