223796-90-5
223796-90-5
Chemical Structure
NS3956
- CAS No.: 223796-90-5
- Formula:C10H14ClN3
- Molecular Weight:211.69
InChIKey: LYMBELAAKZROPC-UHFFFAOYSA-N
SMILES: ClC1=CN=CC(N2CCNCCC2)=C1
Biological Activity: NS3956 is a blood-brain barrier-permeable human α4β2-nicotinic acetylcholine receptor (nAChR) agonist (Ki = 0.36 nM). NS3956 induces dopamine release, produces analgesic effects, modulates rotational behavior in 6-OHDA-lesioned rats, and potentiates the effects of SSRI/SNRI in the forced swim test in mice. NS3956 can be used in research related to depression, Parkinson's disease, and acute pain[1][2][3].
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NS3956 | NS3956 is a blood-brain barrier-permeable human α4β2-nicotinic acetylcholine receptor (nAChR) agonist (Ki = 0.36 nM). NS3956 induces dopamine release, produces analgesic effects, modulates rotational behavior in 6-OHDA-lesioned rats, and potentiates the effects of SSRI/SNRI in the forced swim test in mice. NS3956 can be used in research related to depression, Parkinson's disease, and acute pain. | |||||||||||||||||||||
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References
- [1]. Yu LF, et al. Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors. J Med Chem. 2014;57(20):8204-8223. [Content Brief]
- [2]. Andreasen JT, et al. Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test. J Psychopharmacol. 2011;25(10):1347-1356. [Content Brief]
- [3]. Rode F, et al. Positive allosteric modulation of α4β2 nAChR agonist induced behaviour. Brain Res. 2012;1458:67-75. [Content Brief]
Keywords
