5-Iodo-A-85380 dihydrochloride (Synonyms: 5-I A-85380 dihydrochloride)

Cat. No.: HY-107686 Pureté: 98.97%: Fiche technique
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5-Iodo-A-85380 dihydrochloride is a selective ligand of nAChR. 5-Iodo-A-85380 dihydrochloride binds to α4β2 nAChRs in rat and human brain with K_ds of 12 and 14 pM,respectively.

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5-Iodo-A-85380 dihydrochloride Chemical Structure

CAS No. : 1217837-17-6

Size	Stock	Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Description

5-Iodo-A-85380 dihydrochloride is a selective ligand of nAChR. 5-Iodo-A-85380 dihydrochloride binds to α4β2 nAChRs in rat and human brain with K_ds of 12 and 14 pM,respectively^[1].

Masse moléculaire

363.02

Formule

C₉H₁₃Cl₂IN₂O

CAS No.

1217837-17-6

Appearance

Solid

Color

White to off-white

SMILES

IC1=CC(OC[C@@H]2CCN2)=CN=C1.[H]Cl.[H]Cl

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (137.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7547 mL	13.7733 mL	27.5467 mL
5 mM	0.5509 mL	2.7547 mL	5.5093 mL
10 mM	0.2755 mL	1.3773 mL	2.7547 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 98.97%

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Fiche technique (266 KB) SDS (392 KB)

COA (244 KB) HNMR (253 KB) LCMS (99 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Mukhin AG, et al. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol. 2000 Mar;57(3):642-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7547 mL	13.7733 mL	27.5467 mL	68.8667 mL
	5 mM	0.5509 mL	2.7547 mL	5.5093 mL	13.7733 mL
	10 mM	0.2755 mL	1.3773 mL	2.7547 mL	6.8867 mL
	15 mM	0.1836 mL	0.9182 mL	1.8364 mL	4.5911 mL
	20 mM	0.1377 mL	0.6887 mL	1.3773 mL	3.4433 mL
	25 mM	0.1102 mL	0.5509 mL	1.1019 mL	2.7547 mL
	30 mM	0.0918 mL	0.4591 mL	0.9182 mL	2.2956 mL
	40 mM	0.0689 mL	0.3443 mL	0.6887 mL	1.7217 mL
	50 mM	0.0551 mL	0.2755 mL	0.5509 mL	1.3773 mL
	60 mM	0.0459 mL	0.2296 mL	0.4591 mL	1.1478 mL
	80 mM	0.0344 mL	0.1722 mL	0.3443 mL	0.8608 mL
	100 mM	0.0275 mL	0.1377 mL	0.2755 mL	0.6887 mL

5-Iodo-A-85380 dihydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Iodo-A-853801217837-17-65-I A-85380nAChRNicotinic acetylcholine receptorsnAChRs Ligandα4β2 nAChRsInhibitorinhibitorinhibit

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5-Iodo-A-85380 dihydrochloride (Synonyms: 5-I A-85380 dihydrochloride)

5-Iodo-A-85380 dihydrochloride Related Antibodies

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Activité biologique

Pureté et documentation

Références

Avis client

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