1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. CCMI

CCMI 

Cat. No.: HY-12150 Purity: 100.00%
Handling Instructions

CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction.

For research use only. We do not sell to patients.

CCMI Chemical Structure

CCMI Chemical Structure

CAS No. : 917837-54-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].

IC50 & Target

α7 nAChR[1]

In Vitro

CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs[1].

Molecular Weight

388.25

Formula

C₁₉H₁₅Cl₂N₃O₂

CAS No.

917837-54-8

SMILES

O=C(NC1=CC=C(Cl)C=C1)/C(C2=CC(C)=NO2)=C/NC3=CC=C(Cl)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (257.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5757 mL 12.8783 mL 25.7566 mL
5 mM 0.5151 mL 2.5757 mL 5.1513 mL
10 mM 0.2576 mL 1.2878 mL 2.5757 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.36 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.36 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 100.00%

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CCMInAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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Product Name:
CCMI
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HY-12150
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