917837-54-8
917837-54-8
Chemical Structure
CCMI
Synonym(s): AVL-3288; UCI-4083
- CAS. Nr.: 917837-54-8
- Formula:C19H15Cl2N3O2
- Molecular Weight:388.25
IUPAC Name: (E)-N-(4-chlorophenyl)-3-((4-chlorophenyl)amino)-2-(3-methylisoxazol-5-yl)acrylamide
InChIKey: VMAKIACTLSBBIY-GZTJUZNOSA-N
SMILES: O=C(NC1=CC=C(Cl)C=C1)/C(C2=CC(C)=NO2)=C/NC3=CC=C(Cl)C=C3
Biological Activity: CCMI (AVL-3288) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].
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CCMI | 99.97% | CCMI (AVL-3288) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction. | ||||||||||||||||||||
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