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Results for "

saRNA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cadherin (1) CDK (1) Liposome (8) MDM-2/p53 (1) mRNA (1) Nucleoside Antimetabolite/Analog (2)
By Research Areas:	Cancer (11) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	saRNAs (5) Cationic Lipids (8)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-177531

S-Ac7-DOg	Liposome mRNA	Neurological Disease Inflammation/Immunology Cancer
S-Ac7-DOG is a cationic lipid with biodegradability, low immunogenicity and high nucleic acid transfection capacity, which is commonly used to construct lipid nanoparticles for nucleic acid molecule delivery. S-Ac7-DOG can bind to mRNA, microRNA and self-amplifying RNA through electrostatic interaction. Lipid nanoparticles formed by S-Ac7-DOG enter cells via an energy-dependent endocytic pathway, release nucleic acid cargos, induce antigen-specific CD8 ⁺ T cell responses, promote the generation of precursor memory T cells, and regulate neuroinflammatory pathways. S-Ac7-DOG can be used in the research of retinal diseases, neuroinflammation and cancer .

HY-177373

P21 saRNA	CDK	Cancer
P21 saRNA is a small activating RNA (saRNA) targeting the p21 genes. P21 saRNA induce expression of the p21 genes, and targets the p21 promoters at ?322 relative to gene's transcription start site .

HY-172018

CP-LC-0729	Liposome	Cancer
CP-LC-0729 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-177372

saRNA negative control	Nucleoside Antimetabolite/Analog	Others
saRNA negative control is a saRNA and can be used as a negative control .

HY-177374

Ecad saRNA	Cadherin	Cancer
Ecad saRNA is a small activating RNA (saRNA) targeting the E-cadherin genes. Ecad saRNA induce expression of the E-cadherin genes, and targets the E-cadherin promoters at ?215 relative to gene's transcription start site .

HY-177375

dsP53-285 saRNA	MDM-2/p53	Cancer
dsP53-285 saRNA is a small activating RNA (saRNA) that readily activates wild-type p53 expression by targeting its promoter. dsP53-285 saRNA suppresses bladder cancer cells growth and metastasis .

HY-177371

CEBPA-51 saRNA	Nucleoside Antimetabolite/Analog	Cancer
CEBPA-51 saRNA, a double-stranded RNA oligo duplex to specifically upregulate the transcription of the CEBPA gene. CEBPA-51 saRNA contains multiple 2′-O-methyl modified bases to prevent nonspecific immunostimulatory activity .

HY-171113

CP-LC-1074	Liposome	Cancer
CP-LC-1143 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA).

HY-172016

CP-LC-0867	Liposome	Cancer
CP-LC-0867 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-172014

CP-LC-0743	Liposome	Cancer
CP-LC-0743 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-172015

CP-LC-1143	Liposome	Cancer
CP-LC-1143 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-172017

CP-LC-1254	Liposome	Cancer
CP-LC-1254 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-W1130407

CP-LC-1073	Liposome	Others
CP-LC-1073 is a specific ionizable cationic amino lipid derived from the amino acid homocysteine. CP-LC-1073 can used in lipid nanoparticle (LNP) formulations for efficient in vivo delivery and expression of RNA (mRNA, cRNA, saRNA).

Cat. No.	Product Name		Classification

HY-177531

S-Ac7-DOg		Cationic Lipids
S-Ac7-DOG is a cationic lipid with biodegradability, low immunogenicity and high nucleic acid transfection capacity, which is commonly used to construct lipid nanoparticles for nucleic acid molecule delivery. S-Ac7-DOG can bind to mRNA, microRNA and self-amplifying RNA through electrostatic interaction. Lipid nanoparticles formed by S-Ac7-DOG enter cells via an energy-dependent endocytic pathway, release nucleic acid cargos, induce antigen-specific CD8 ⁺ T cell responses, promote the generation of precursor memory T cells, and regulate neuroinflammatory pathways. S-Ac7-DOG can be used in the research of retinal diseases, neuroinflammation and cancer .

HY-177373

P21 saRNA		saRNAs
P21 saRNA is a small activating RNA (saRNA) targeting the p21 genes. P21 saRNA induce expression of the p21 genes, and targets the p21 promoters at ?322 relative to gene's transcription start site .

HY-172018

CP-LC-0729		Cationic Lipids
CP-LC-0729 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-177372

saRNA negative control		saRNAs
saRNA negative control is a saRNA and can be used as a negative control .

HY-177374

Ecad saRNA		saRNAs
Ecad saRNA is a small activating RNA (saRNA) targeting the E-cadherin genes. Ecad saRNA induce expression of the E-cadherin genes, and targets the E-cadherin promoters at ?215 relative to gene's transcription start site .

HY-177375

dsP53-285 saRNA		saRNAs
dsP53-285 saRNA is a small activating RNA (saRNA) that readily activates wild-type p53 expression by targeting its promoter. dsP53-285 saRNA suppresses bladder cancer cells growth and metastasis .

HY-177371

CEBPA-51 saRNA		saRNAs
CEBPA-51 saRNA, a double-stranded RNA oligo duplex to specifically upregulate the transcription of the CEBPA gene. CEBPA-51 saRNA contains multiple 2′-O-methyl modified bases to prevent nonspecific immunostimulatory activity .

HY-171113

CP-LC-1074		Cationic Lipids
CP-LC-1143 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA).

HY-172016

CP-LC-0867		Cationic Lipids
CP-LC-0867 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-172014

CP-LC-0743		Cationic Lipids
CP-LC-0743 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-172015

CP-LC-1143		Cationic Lipids
CP-LC-1143 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-172017

CP-LC-1254		Cationic Lipids
CP-LC-1254 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .

HY-W1130407

CP-LC-1073		Cationic Lipids
CP-LC-1073 is a specific ionizable cationic amino lipid derived from the amino acid homocysteine. CP-LC-1073 can used in lipid nanoparticle (LNP) formulations for efficient in vivo delivery and expression of RNA (mRNA, cRNA, saRNA).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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