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Results for "

sars-cov-2-plpro

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SARS-CoV (18) Virus Protease (10)
By Research Areas:	Cancer (1) Infection (18) Inflammation/Immunology (1)

Inhibitors & Agonists

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17542

PLpro inhibitor 5 Publications Verification	SARS-CoV	Infection
PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC₅₀ of 2.6 µM . PLpro inhibitor inhibits *SARS-CoV-2 PLpro* with an IC₅₀ of 5.0 µM and an EC₅₀ of 21.0 µM ^[2].

HY-169092

PF-07957472	SARS-CoV Virus Protease	Infection
PF-07957472 (Compound 4) is an orally active and selective *SARS-CoV-2* papain-like protease *(PLpro)* inhibitor, with a K_i of 2 nM against SARS-CoV-2 PLpro. PF-07957472 reduces SARS-CoV-2 viral titers in the lungs of infected mice and inhibits SARS-CoV-2-induced cytopathic effects in cells. PF-07957472 can be used for the research of COVID-19 .

HY-178160

SARS-CoV-2 PLpro-IN-2	SARS-CoV Virus Protease	Infection
SARS-CoV-2 PLpro-IN-2 (Compound 12) is a highly selective SARS-CoV-2 papain-like protease (PLpro) inhibitor of (IC₅₀=0.06 μM). SARS-CoV-2 PLpro-IN-2 inhibits viral replication and immune evasion. SARS-CoV-2 PLpro-IN-2 exhibits antiviral efficacy in HeLa-ACE2 cells (EC₅₀=2.9 μM). SARS-CoV-2 PLpro-IN-2 is promising for research of COVID-19 .

HY-170399

SARS-CoV-2 PLpro-IN-1	SARS-CoV Virus Protease	Infection Cancer
SARS-CoV-2 PLpro-IN-1 (Compound 85) is a non-covalent and competitive inhibitor of *SARS-CoV-2 PLpro* with an IC₅₀ of 15.06 μM and a K_i of 22.93 μM. SARS-CoV-2 PLpro-IN-1 inhibits the proliferation of Vero cell with an IC₅₀ of 7.47 μM .

HY-159655

PLpro-IN-6	SARS-CoV	Infection Inflammation/Immunology
PLpro-IN-6 (compound 6) is a papain-like protease *(PLpro)* inhibitor, with an IC₅₀ of 0.019 μM for SARS CoV2 PLpro enzyme .

HY-181927

SARS-CoV-2 PLpro-IN-7	SARS-CoV Virus Protease	Infection
SARS-CoV-2 PLpro-IN-7 (Compound 18) is a selective *SARS-CoV-2 PLpro* inhibitor with an IC₅₀ of 13.3 μM. SARS-CoV-2 PLpro-IN-7 exerts antiviral activity against SARS-CoV-2 (with an EC₅₀ of 11 μM for SARS-CoV-2 in Huh7.5 cells). SARS-CoV-2 PLpro-IN-7 is applicable to research related to COVID-19 .

HY-139892

XR8-69	SARS-CoV	Infection
XR8-69 is a *SARS-CoV-2 PLpro* inhibitor that shows low micromolar antiviral potency in SARS-CoV-2-infected human cells.

HY-149256

PLpro/RBD-IN-1	SARS-CoV	Infection
PLpro/RBD-IN-1 (compound 5) is a dual *SARS-CoV-2 PLpro* and spike protein RBD inhibitor with IC₅₀s of 7.197 μM and 8.673 μM, respectively .

HY-157144

SARS-CoV-2-IN-68	SARS-CoV	Infection
SARS-CoV-2-IN-68 (compound 6C) is a covalent *SARS-CoV-2 PLpro/Mpro* inhibitor with potent antiviral activities. SARS-CoV-2-IN-68 binds to Zn-finger domain of PLpro .

HY-162790

SARS-CoV-2-IN-95	SARS-CoV Virus Protease	Infection
SARS-CoV-2-IN-95 (Compound 10) is an inhibitor for *SARS-CoV-2 PLpro* with an IC₅₀ of 0.39 μM. SARS-CoV-2-IN-95 exhibits antiviral activity in mouse SARS-CoV-2-infected model .

HY-174402

PLpro-IN-9	SARS-CoV	Infection
PLpro-IN-9 (Compound 14e) is a *SARS-CoV-2 PLpro* inhibitor with an IC₅₀ of 12.0 μM and a K_D of 1.86 μM. PLpro-IN-9 has low cytotoxicity but poor metabolic stability. PLpro-IN-9 can be used in the research of SARS-CoV-2 .

HY-149940

SIMR3030	SARS-CoV	Infection
SIMR3030 is a potent *SARS-CoV-2 PLpro* inhibitor with an IC₅₀ value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice .

HY-168259

PLpro-IN-8	SARS-CoV	Infection
PLpro-IN-8 (compound 1) is a SARS-CoV papain-like protease (PLpro) inhibitor with IC₅₀ values of 5.9 μM and 0.46 μM for SARS-CoV-2 PLpro and SARS -CoV-1 PLpro, respectively. PLpro-IN-8 inhibits Wuhan strain WK-521 of SARS-CoV-2 with an EC₅₀ of 2.7 μM .

HY-168917

9-Aminominocycline 9-AMN	SARS-CoV Virus Protease	Infection
9-Aminominocycline (9-AMN) is the inhibitor for SARS-CoV-2 papain-like protease (SARS-CoV-2 PLpro), inhibits its deubiquitination (DUB) activity and protease activity with IC₅₀ of 4.55 µM and 4.15 µM. 9-Aminominocycline inhibits the SARS-CoV variants Delta and Omicron replication in Calu-3 cell with IC₅₀ of 1.04 µM and 2.35 µM .

HY-179293

SARS-CoV-2 PLpro-IN-3	SARS-CoV Virus Protease	Infection
SARS-CoV-2 PLpro-IN-3 (Compound 15) is a covalent inhibitor of the *SARS-CoV-2* papain-like protease (PLpro), with an IC₅₀ of 25 nM. SARS-CoV-2 PLpro-IN-3 has similar inhibitory activity against SARS-CoV PLpro (IC₅₀ = 59 nM), but shows no inhibitory effect on human ubiquitin-specific protease 7 (USP7). The EC₅₀ of SARS-CoV-2 PLpro-IN-3 in inhibiting SARS-CoV-2 replication in cells is 96 nM, significantly reducing the viral titer and viral RNA levels. SARS-CoV-2 PLpro-IN-3 can be used for studying SARS-CoV-2 drug resistance mutations .

HY-181262

SARS-CoV-2 PLpro-IN-4	SARS-CoV Virus Protease	Infection
SARS-CoV-2 PLpro-IN-4 is a *SARS-CoV-2* papain-like protease (PL ^Pro) inhibitor with an IC₅₀ of 0.4 μM. SARS-CoV-2 PLpro-IN-4 binds to the S3 and S4 pockets of SARS-CoV-2 PL ^Pro, thereby functionally inhibiting its activity. SARS-CoV-2 PLpro-IN-4 exhibits antiviral activity and can be used in research on COVID-19 .

HY-181641

SARS-CoV-2 PLpro-IN-6	SARS-CoV Virus Protease	Infection
SARS-CoV-2 PLpro-IN-6 is an irreversible SARS-CoV-2 papain-like protease inhibitor with an IC₅₀ value of 0.059 μM. SARS-CoV-2 PLpro-IN-6 exhibits antiviral activity and can be used in studies related to COVID-19 .

HY-181352

SB-140	Virus Protease SARS-CoV	Infection
SB-140 is a selective, covalent *PLpro* inhibitor with an IC₅₀ of ≤2.5 nM against SARS-CoV-2 PLpro. SB-140 has antiviral activity against *SARS-CoV-2, MERS-CoV* and SARS-CoV-1 .

Recombinant Proteins Recommended:

SARS-CoV-2 Plpro

Species:	Virus (3)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702190

	SARS-CoV-2 PL-PRO Protein (His) Replicase polyprotein 1a; pp1a; ORF1a polyprotein	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. SARS-CoV-2 PL-PRO Protein (His) is the recombinant Virus-derived PL-PRO protein, expressed by E. coli , with N-6*His labeled tag.

HY-P76021

	SARS-CoV-2 Plpro/Papain-like protease Protein (His) sars-cov-2 (2019-ncov) plpro/papain-like protease-His Protein	Virus	E. coli
	SARS-CoV-2 NSP3 (NSP3) is one of non-structure protein that binds to viral RNA, nucleocapsid protein, as well as other viral proteins, and contributes in polyprotein processing. NSP3 has also an important role in innate immune response antagonism and is responsible for release of NSP1, NSP2, and NSP3 from the N-terminal region of pp1a and pp1ab. SARS-CoV-2 Plpro/Papain-like protease Protein (His) is the recombinant Virus-derived SARS-CoV-2 Plpro/Papain-like protease protein, expressed by E. coli , with N-His labeled tag.

HY-P70122

	SARS-CoV-2 PLpro Protein 1 Publications Verification rReplicase polyprotein 1ab/2019-ncov Papain-Like Protease; Papain-like Protease; plpro; PL-PRO; pp1a; Replicase polyprotein 1a	Virus	E. coli
	The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. SARS-CoV-2 PLpro Protein is the recombinant Virus-derived SARS-CoV-2 PLpro protein, expressed by E. coli , with tag free.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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