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Cat. No.: HY-162790

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SARS-CoV-2-IN-95

SARS-CoV-2-IN-95 (Compound 10) is an inhibitor for SARS-CoV-2 PLpro with an IC₅₀ of 0.39 μM. SARS-CoV-2-IN-95 exhibits antiviral activity in mouse SARS-CoV-2-infected model.

For research use only. We do not sell to patients.

CAS No.: 2817810-96-9
Formula: C₂₉H₃₆N₄OS
Molecular Weight:488.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SARS-CoV-2-IN-95 Chemical Structure

CAS No.: 2817810-96-9

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Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

SARS-CoV-2-IN-95 (Compound 10) is an inhibitor for SARS-CoV-2 PLpro with an IC₅₀ of 0.39 μM. SARS-CoV-2-IN-95 exhibits antiviral activity in mouse SARS-CoV-2-infected model^[1].

IC₅₀ & Target

IC₅₀: 0.39 μM (SARS-CoV-2 PLpro)

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	43 μM Compound: 10; XR8-23	Cytotoxicity against human A549 cells harbouring hACE2 assessed as reduction in cell viability by Celltiter-glo luminescent cell viability assay Cytotoxicity against human A549 cells harbouring hACE2 assessed as reduction in cell viability by Celltiter-glo luminescent cell viability assay	[PMID: 39102360]

Chemical Information

CAS No. 2817810-96-9
Molecular Weight 488.69
Formula C₂₉H₃₆N₄OS
SMILES

CC1=CC=C(NC2CNC2)C=C1C(N[C@H](C)C3=CC(C4=CC=C(CNC5CCCC5)S4)=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Velma GR, et al., Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity. J Med Chem. 2024 Aug 5. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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