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Cat. No.: HY-149256

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PLpro/RBD-IN-1

PLpro/RBD-IN-1 (compound 5) is a dual SARS-CoV-2 PLpro and spike protein RBD inhibitor with IC₅₀s of 7.197 μM and 8.673 μM, respectively.

For research use only. We do not sell to patients.

CAS No.: 1282451-83-5
Formula: C₁₃H₁₀N₄O
Molecular Weight:238.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PLpro/RBD-IN-1 Chemical Structure

CAS No.: 1282451-83-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PLpro/RBD-IN-1 (compound 5) is a dual SARS-CoV-2 PLpro and spike protein RBD inhibitor with IC₅₀s of 7.197 μM and 8.673 μM, respectively^[1].

IC₅₀ & Target

IC50: 7.197 μM (SARS-CoV-2 PLpro) and 8.673 μM (spike protein RBD)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	45.775 μM Compound: 5	Cytotoxicity against human long-term A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human long-term A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36966652]
WI-38	CC₅₀	51.781 μM Compound: 5	Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36966652]

Chemical Information

CAS No. 1282451-83-5
Molecular Weight 238.24
Formula C₁₃H₁₀N₄O
SMILES

NC1=C(C=CC=C1)C2=NOC(C3=CC=NC=C3)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mohammed Salah Ayoup, et al. Repurposing 1,2,4-oxadiazoles as SARS-CoV-2 PLpro inhibitors and investigation of their possible viral entry blockade potential. Eur J Med Chem. 2023 Apr 5;252:115272. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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