SB-140
SB-140 is a selective, covalent PLpro inhibitor with an IC50 of ≤2.5 nM against SARS-CoV-2 PLpro. SB-140 has antiviral activity against SARS-CoV-2, MERS-CoV and SARS-CoV-1.
For research use only. We do not sell to patients.
- Formula: C28H35F3N4O3
- Molecular Weight:532.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SB-140 (15 min) potently inhibits purified SARS-CoV-2 PLpro with an IC50 ≤ 2.5 nM[1].
SB-140 (1 μM) exhibits high selectivity, with no inhibitory activity detected against 47 human DUBs and 9 cysteine proteases at a concentration of 1 μM[1].
SB-140 (0-10 μM; 1 h) potently inhibits SARS-CoV-2 replication in A549-ACE2 cells, with an EC50 of 0.3 nM and an EC90 of 3 nM[1].
SB-140 (0.01-100 μM) exhibits attenuated inhibitory activity against MERS-CoV replication in A549-ACE2 cells, with an EC50 of 1.17 μM[1].
SB-140 (0-1 μM) inhibits SARS-CoV-1 in A549-ACE2 cells, with an EC50 of 14.1 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 532.60
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Formula C28H35F3N4O3
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SMILES
CCOC1=CC2=C(C=CC=C2[C@@H](C)N3CCC([C@@H](CN)C(NCC(NCC#CC(F)(F)F)=O)=O)CC3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB-140 Related Classifications
HY-181352 Related Classifications
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