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smooth muscle dilator

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4

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製品番号 製品名 Target 研究分野 構造式
  • HY-101952
    Prostaglandin E2
    50+ Cited Publications

    PGE2; Dinoprostone

    		 Organoid Prostaglandin Receptor Endogenous Metabolite Cardiovascular Disease Endocrinology
    Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
    Prostaglandin E2
  • HY-N0165
    Methyl-Hesperidin

    		HIV Reverse Transcriptase Cardiovascular Disease Infection Inflammation/Immunology
    Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .
    Methyl-Hesperidin
  • HY-B2141
    Bendazol

    		NO Synthase HIF/HIF Prolyl-Hydroxylase Cardiovascular Disease Others Metabolic Disease
    Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats .
    Bendazol
  • HY-B0347
    Lacidipine
    2 Publications Verification

    		 Calcium Channel Reactive Oxygen Species (ROS) Caspase Apoptosis Cardiovascular Disease
    Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .
    Lacidipine
  • HY-101952R
    Prostaglandin E2 (Standard)
    50+ Cited Publications

    PGE2(Standard); Dinoprostone (Standard)

    		 Reference Standards Prostaglandin Receptor Endogenous Metabolite Cardiovascular Disease Endocrinology
    Prostaglandin E2 (Standard) is the analytical standard of Prostaglandin E2. This product is intended for research and analytical applications. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
    Prostaglandin E2 (Standard)
  • HY-101952S
    Prostaglandin E2-d4
    2 Publications Verification

    PGE2-d4; Dinoprostone-d4

    		 Prostaglandin Receptor Endogenous Metabolite Cardiovascular Disease Endocrinology
    Prostaglandin E2-d4 is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation .
    Prostaglandin E2-d4
  • HY-W013195
    8-Bromoadenosine

    		Nucleoside Antimetabolite/Analog Cancer
    8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. 8-Bromoadenosine can quench the intrinsic fluorescence of human serum albumin (HSA) through static quenching procedure. 8-Bromoadenosine can be used to synthesize adenosine phosphate, such as Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
    8-Bromoadenosine
  • HY-B1035
    Levobunolol hydrochloride
    1 Publications Verification

    l-Bunolol hydrochloride

    		 Adrenergic Receptor Calcium Channel Casein Kinase Cardiovascular Disease
    Levobunolol (l-Bunolol) hydrochloride is a non-selective β-adrenergic antagonist and vasodilator. By blocking calcium ion influx and reducing the sensitivity of vascular smooth muscle to calcium, Levobunolol hydrochloride effectively dilates the ciliary arteries and increases ocular blood flow, so it is widely used in research on glaucoma and ocular hypertension. Levobunolol hydrochloride inhibits the β-receptor signaling pathway and the expression of related proliferation markers (such as CK3, CK14, CK19, Ki67) in corneal cells. In rabbit models, Levobunolol hydrochloride not only does not inhibit corneal epithelial regeneration, but also accelerates the healing of mechanical injury without adverse effects. Levobunolol hydrochloride also inhibits histamine-induced vasoconstriction and intracellular calcium elevation, exhibiting unique vascular regulatory activity. Levobunolol hydrochloride protects ocular blood flow and promotes corneal repair .
    Levobunolol hydrochloride
  • HY-19664
    Pranidipine

    OPC-13340

    		 Calcium Channel NO Synthase Cardiovascular Disease
    Pranidipine (OPC-13340) is an orally active L-type voltage-dependent calcium channel (L-VDCC) blocker with a Ki value of 0.16 nM. Pranidipine inhibits calcium-induced contraction, suppresses slow-response action potentials, shortens action potential duration, reduces systolic and diastolic blood pressure, and exerts vasodilatory effects. Pranidipine enhances its vasodilatory effect by blocking NO decomposition. Pranidipine can be used in research related to essential hypertension, angina pectoris, myocardial infarction, and dilated cardiomyopathy .
    Pranidipine
  • HY-101952S1
    Prostaglandin E2-d9

    PGE2-d9; Dinoprostone-d9

    		 Isotope-Labeled Compounds Prostaglandin Receptor Endogenous Metabolite Cardiovascular Disease Endocrinology
    Prostaglandin E2-d9 is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation .
    Prostaglandin E2-d9
  • HY-B0347S1
    Lacidipine-13C8

    		Apoptosis Caspase Calcium Channel Reactive Oxygen Species (ROS) Cardiovascular Disease
    Lacidipine- 13C8 is the deuterium labeled Lacidipine . Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .
    Lacidipine-13C8
  • HY-N12777
    Coixenolide

    		Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    Coixenolide can be isolated from coix seeds, and exhibits anti-inflammatory, anti-tumor and pain-reducing activities. Coixenolide stimulates the lung, heart, striated and smooth muscles at low doses, while inhibits at high doses. Coixenolide dilates pulmonary veins and improves pulmonary blood circulation. Coixenolide can also be used as nutraceuticals and functional foods. Coixenolide enhances the prodcutionof mycelia biomass and polysaccharides when added to the media of submerged culture of G. lucidum. Coixenolide affects the synthesis level of phosphoglucose isomerase and α-phosphoglucomutase .
    Coixenolide
  • HY-N16467
    Uncarine F

    Speciofiline

    		 Others Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Uncarine F (Speciofiline) is a pentacyclic oxindole alkaloid found in Uncaria tomentosa. Uncaria alkaloids have wide medicinal properties, including neuroprotective, anticancer, and antihypertensive activities. Uncaria alkaloids may stimulate the immune system, relax smooth muscles, dilate blood vessels, and act as a diuretic. Uncarine F can be used for the researches of cancer, immunology, cardiovascular and neurological disease .
    Uncarine F
  • HY-119750
    Budralazine

    		Adrenergic Receptor Cardiovascular Disease
    Budralazine is a vasodilator, which dilates the vascular smooth muscle and exhibits hypotensive efficacy. Budralazine inhibits the central sympathetic nerve and exhibits an anti-tachycardic effect .
    Budralazine
  • HY-129445
    SG-209

    		Potassium Channel Cardiovascular Disease
    SG-209 is a Nicorandil (HY-B0341) derivative that produces relaxation through potassium channel activation, while this action contributes to the vasodilating action of Nicorandil (HY-B0341) at higher concentrations. SG-209 dilates tracheal smooth muscle and increases tracheal blood flow in anesthetized dogs .
    SG-209
  • HY-14915A
    Bedoradrine sulfate

    MN-221; KUR-1246

    		 Adrenergic Receptor Inflammation/Immunology
    Bedoradrine (MN-221) sulfate is a highly selective β2-adrenergic receptor agonist. Bedoradrine sulfate can effectively relieve airway spasm, dilate airway smooth muscle cells, reduce airway inflammation, and thus improve respiratory function. Bedoradrine sulfate can be used in research on asthma .
    Bedoradrine sulfate
  • HY-B0347S3
    Lacidipine-13C4

    		Calcium Channel Caspase Reactive Oxygen Species (ROS) Apoptosis Isotope-Labeled Compounds Cardiovascular Disease
    Lacidipine- 13C4 is 13C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .
    Lacidipine-13C4
  • HY-B0347R
    Lacidipine (Standard)

    		Reference Standards Calcium Channel Reactive Oxygen Species (ROS) Caspase Apoptosis Cardiovascular Disease
    Lacidipine (Standard) is the analytical standard of Lacidipine. This product is intended for research and analytical applications. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .
    Lacidipine (Standard)
  • HY-B1035A
    Levobunolol

    l-Bunolol

    		 Adrenergic Receptor Casein Kinase Calcium Channel Others
    Levobunolol (l-Bunolol) is a non-selective β-adrenergic antagonist and vasodilator. By blocking calcium ion influx and reducing the sensitivity of vascular smooth muscle to calcium, Levobunolol effectively dilates the ciliary arteries and increases ocular blood flow, so it is widely used in research on glaucoma and ocular hypertension. Levobunolol inhibits the β-receptor signaling pathway and the expression of related proliferation markers (such as CK3, CK14, CK19, Ki67) in corneal cells. In rabbit models, Levobunolol not only does not inhibit corneal epithelial regeneration, but also accelerates the healing of mechanical injury without adverse effects. Levobunolol also inhibits histamine-induced vasoconstriction and intracellular calcium elevation, exhibiting unique vascular regulatory activity. Levobunolol protects ocular blood flow and promotes corneal repair .
    Levobunolol
  • HY-114986
    6-Keto-PGE1
    1 Publications Verification

    6-keto-Prostaglandin E1

    		 β-glucuronidase Cardiovascular Disease
    6-Keto-PGE1 (6-keto-Prostaglandin E1) is a biologically active derivative of PGE1. 6-Keto-PGE1 inhibits adenosine diphosphate-induced platelet aggregation. 6-Keto-PGE1 reduces cardiac afterload, decreases the accumulation of plasma myocardial depressant factor (MDF), lowers arterial blood pressure, dilates vascular beds, inhibits the vasoconstrictive response of vascular smooth muscle, and increases pulmonary compliance. 6-Keto-PGE1 directly stabilizes isolated cat liver lysosomes and significantly reduces the release of β-glucuronidase and cathepsin D. 6-Keto-PGE1 prolongs the survival time of traumatized rats and exerts protective effects through hemodynamic and cytoprotective actions. 6-Keto-PGE1 reduces central airway resistance. 6-Keto-PGE1 can be used in studies related to traumatic shock .
    6-Keto-PGE1
  • HY-N0165R
    Methyl-Hesperidin (Standard)

    		Reference Standards HIV Reverse Transcriptase Cardiovascular Disease Infection Inflammation/Immunology
    Methyl-Hesperidin (Standard) is the analytical standard of Methyl-Hesperidin (HY-N0165). This product is intended for research and analytical applications. Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .
    Methyl-Hesperidin (Standard)

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