4499-40-5
Chemical Structure
Choline theophyllinate
Synonym(s): Oxtriphylline
- CAS No.: 4499-40-5
- Formula:C12H21N5O3
- Molecular Weight:283.33
IUPAC Name: 2-hydroxy-N,N,N-trimethylethan-1-aminium 1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-9-ide
InChIKey: RLANKEDHRWMNRO-UHFFFAOYSA-M
SMILES: C[N+](C)(CCO)C.CN1C2=C(C(N(C1=O)C)=O)N=C[N-]2
Biological Activity: Choline theophyllinate (Oxtriphylline) is an orally active methylxanthine derivative. Choline theophyllinate exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline theophyllinate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. It modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline theophyllinate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma[1][2][3].
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Choline theophyllinate | 99.95% | Choline theophyllinate (Oxtriphylline) is an orally active methylxanthine derivative. Choline theophyllinate exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline theophyllinate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. It modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline theophyllinate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma. | ||||||||||||||||||||
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Choline theophyllinate (Standard) | ≥98% | Choline theophyllinate (Standard) (Oxtriphylline (Standard)) is the analytical standard of Choline theophyllinate (HY-B1718). This product is intended for research and analytical applications. Choline theophyllinate (Oxtriphylline) is an orally active methylxanthine derivative. Choline theophyllinate exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline theophyllinate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. It modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline theophyllinate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma. | ||||||||||||||||||||
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References
- [1]. ARMITAGE AK, et al. Thioxanthines with potent brochodilator and coronary dilator properties. Br J Pharmacol Chemother. 1961 Feb;16(1):59-76.
- [2]. Rhind GB, et al. Sustained release choline theophyllinate in nocturnal asthma. British medical journal (Clinical research ed.). 1985 Dec 07;291(6509):1605-7.
- [3]. Hibberd SG, et al. Acute and chronic pharmacokinetics of asymmetrical doses of slow release choline theophyllinate in asthma. British journal of clinical pharmacology. 1986 Sep;22(3):337-41.
