Choline-d4 chloride
Based on 1 publication(s) in Google Scholar
Choline-d4 chloride is the d4-labeled Choline chloride (HY-B1337). Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma.
For research use only. We do not sell to patients.
- Purity : 99.90%
- CAS No.: 285979-70-6
- Formula: C5H10D4ClNO
- Molecular Weight:143.65
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Choline-d4 chloride
MoreAll Histamine Receptor Isoforms
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Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 285979-70-6
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Unlabeled CAS 67-48-1
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Appearance Solid
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Molecular Weight 143.65
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Formula C5H10D4ClNO
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Color White to off-white
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SMILES
[2H]C([2H])(O)C([N+](C)(C)C)([2H])[2H].[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
Diversity of human choline transporters: substrate specificity, kinetic properties, and inhibitor sensitivity. [Abstract]2025 Dec;242(Pt 2):117343. PMID: 40972734
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (696.14 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Protocol for Open Field Test (OF)
The Open Field Test is a rodent behavioral assay that measures spontaneous locomotion, exploratory behavior, and anxiety-like behavior when an animal is placed in a novel open arena. The main readouts are total distance traveled, movement time, velocity, center-zone entries, center-zone time, peripheral-zone time, and thigmotaxis. The assay is based on the conflict between exploration of a novel environment and avoidance of exposed open areas; higher center exploration is commonly interpreted as lower anxiety-like behavior, whereas increased wall-following or peripheral occupancy is interpreted as higher anxiety-like behavior.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.9614 mL | 34.8068 mL | 69.6136 mL | 174.0341 mL |
| 5 mM | 1.3923 mL | 6.9614 mL | 13.9227 mL | 34.8068 mL | |
| 10 mM | 0.6961 mL | 3.4807 mL | 6.9614 mL | 17.4034 mL | |
| 15 mM | 0.4641 mL | 2.3205 mL | 4.6409 mL | 11.6023 mL | |
| 20 mM | 0.3481 mL | 1.7403 mL | 3.4807 mL | 8.7017 mL | |
| 25 mM | 0.2785 mL | 1.3923 mL | 2.7845 mL | 6.9614 mL | |
| 30 mM | 0.2320 mL | 1.1602 mL | 2.3205 mL | 5.8011 mL | |
| 40 mM | 0.1740 mL | 0.8702 mL | 1.7403 mL | 4.3509 mL | |
| 50 mM | 0.1392 mL | 0.6961 mL | 1.3923 mL | 3.4807 mL | |
| 60 mM | 0.1160 mL | 0.5801 mL | 1.1602 mL | 2.9006 mL | |
| 80 mM | 0.0870 mL | 0.4351 mL | 0.8702 mL | 2.1754 mL | |
| 100 mM | 0.0696 mL | 0.3481 mL | 0.6961 mL | 1.7403 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Choline-d4 chloride Related Classifications
HY-B1337S Related Classifications
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