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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
stratum corneum lipids
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "stratum corneum lipids" in MCE Product Catalog:
2
Research Areas:
C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss .
Synonyms: N-Stearoyl phytosphingosine
Cat. No.: HY-122056
CAS No.: 39036-04-9
Synonyms: L-α-Diheptanoyllecithin; 12-Diheptanoyl-sn-glycero-3-PC
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1,2-Diheptanoyl-SN-glycero-3-phosphocholine (L-α-Diheptanoyllecithin; 12-Diheptanoyl-sn-glycero-3-PC) is a short-chain phospholipid. 11,2-Diheptanoyl-SN-glycero-3-phosphocholine forms bimolecular micelles with long-chain phospholipids, and these micelles undergo adsorption and spontaneous fusion to generate supported lipid bilayers. 1,2-Diheptanoyl-SN-glycero-3-phosphocholine enhances the transdermal penetration of hydrophilic low-molecular-weight compounds via micellar pretreatment of the skin of hairless mice. 1,2-Diheptanoyl-SN-glycero-3-phosphocholine can be used in studies of membrane biology, structural biology and transdermal drug delivery .
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Oleyl alcohol is an anti-tumor compound that inhibits tumor growth. Oleyl alcohol induces cytotoxicity, cell death and apoptosis. The intracellular accumulation of Oleyl alcohol correlates with its cytotoxicity against tumor cells. Oleyl alcohol forms enhancer-enriched fluid domains in stratum corneum lipids, increases the retention of diclofenac diethylamine in ex vivo human epidermis and dermis, and enhances the skin permeability of diclofenac diethylamine. Oleyl alcohol can be used in studies related to neuroblastoma .
Cat. No.: HY-B2119
CAS No.: 41945-48-6
Synonyms: Tauroglycocholic acid sodium salt
Target:
Research Areas:
Sodium tauroglycocholate (Tauroglycocholic acid sodium salt) is a multifunctional surfactant and penetration enhancer that can serve as a cholegraphic contrast agent. In organic solvents, Sodium tauroglycocholate embeds and stabilizes invertase by forming reverse micelles, and prolongs its active lifespan. In terms of transdermal absorption, Sodium tauroglycocholate effectively regulates the flux of aminophylline through snake slough by binding to keratin filaments, disrupting keratinocytes and altering lipid components of the stratum corneum. It exhibits rapid penetration characteristics without lag time at a concentration of 100 μg/mL. Sodium tauroglycocholate does not interfere with the hepatic uptake of Gd-EOB-DTPA by the bile acid transport system in rat hepatocytes .
Cat. No.: HY-141582S
CAS No.: 1354806-91-9
Synonyms: N-Stearoyl phytosphingosine-d3
Cat. No.: HY-176500
CAS No.: 3035022-30-8
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Sphingolipid E is a synthetic pseudoceramide sphingolipid similar to type 2 ceramide with a metastable lamellar structure. Sphingolipid E ??can be used as a potential drug carrier to control the penetration of molecules as a lipid component of the intercellular space of the stratum corneum .
Cat. No.: HY-N15594
CAS No.: 110483-07-3
Synonyms: SLE
Category:
Target:
Cat. No.: HY-175088
Synonyms: C48:2 EOP (t18:0/30:0w18:2 (9Z,12Z)); N-(30-Linoleoyloxy-triacontanoyl)-phytosphingosine
Target:
Research Areas:
EOP (t18:0/30:0/18:2) (C48:2 EOP (t18:0/30:0w18:2 (9Z,12Z)); N-(30-Linoleoyloxy-triacontanoyl)-phytosphingosine) is a plant ceramide-based EOS analog. EOP (t18:0/30:0/18:2) is formed by esterifying an ω-hydroxy very long chain ceramide (C28-36) with the essential fatty acid linoleic acid. EOP (t18:0/30:0/18:2) has been used as a component of a model stratum corneum lipid mixture .
Cat. No.: HY-125533
CAS No.: 1404289-52-6
TXA497 is a potent local topical bactericide. TXA497 exerts its bactericidal effect by interfering with the polymerization kinetics of the bacterial cell division protein FtsZ, rather than inhibiting it. TXA497 shows strong activity against various Staphylococcus aureus strains, including MRSA and MSSA, with an MIC value ranging from 1.0 to 2.0 μg/mL. TXA497 skin deposition is concentration-dependent in its formulation, consistent with Fick's first law. TXA497 has limited systemic permeability through the lipid pathway of the stratum corneum and is easily absorbed through this route. TXA497 can be used for research on topical bactericidal agents .
Cat. No.: HY-160559
CAS No.: 873802-43-8
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Ceramide 8 is a free 6-hydroxylated ceramide found in human skin with (2S,3R,4E,6R) stereochemical configuration. Ceramide 8 is a predominant lipid component of human epidermal stratum corneum. Ceramide 8 contributes to the skin's water barrier function that prevents body water loss .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
