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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
thiophene derivatives
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "thiophene derivatives" in MCE Product Catalog:
3
3 Cited Publications
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Research Areas:
VCH-916 is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase. VCH-916 binds to Thumb Site II. VCH-916 can be used for the research of hepatitis c virus (hcv) infection .
2
2 Cited Publications
Synonyms: NSC55712; TPU-260 Dihydrochloride
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
TPT-260 Dihydrochloride (NSC55712), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (Kd = ~5 µM). TPT-260 Dihydrochloride increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 Dihydrochloride inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 Dihydrochloride improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 Dihydrochloride exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 Dihydrochloride can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease .
Cat. No.: HY-W002251
CAS No.: 5381-20-4
Antimicrobial agent-14, a benzyl thiophene sulfonamide derivative is an antimicrobial agent, with a MIC of 200 μM against Campylobacter coli ATCC33559. Antimicrobial agent-14 can be used for the research of bacterial foodborne gastroenteritis .
Cat. No.: HY-151581
CAS No.: 2977251-08-2
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HCVcc-IN-1 is a benzothiazole-2-thiophene S-glycoside derivative with low toxic and antiviral activity .
Cat. No.: HY-W001968
CAS No.: 498-62-4
Synonyms: 3-TC
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3-Thiophenecarboxaldehyde is a thiophene derivative substrate for biocatalytic reduction to 3-thiophenemethanol, and can be processed by Pseudomonas putida S12 cells. 3-Thiophenecarboxaldehyde functions as an intermediate compound. 3-Thiophenecarboxaldehyde exhibits toxicity toward Pseudomonas putida S12 cells at elevated concentrations, reducing specific growth rate and final biomass yield .
Cat. No.: HY-W002315
CAS No.: 573-54-6
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2-Bromo-3-nitrobenzoic acid is a brominated nitrobenzoic acid and also a starting material for the synthesis of 3-substituted-5-nitroisocoumarins. 3-Substituted-5-nitroisocoumarins are key intermediates of PARP inhibitor analogs. 2-Bromo-3-nitrobenzoic acid serves as an easily accessible precursor for the synthesis of 7-nitrobenzo[b]thiophene and 7-nitro-1,2-benzisothiazole derivatives .
Cat. No.: HY-13769
CAS No.: 769856-81-7
Synonyms: TPU260
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
TPT-260 (TPU260), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (Kd = ~5 µM). TPT-260 increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease .
Cat. No.: HY-151588
CAS No.: 2977251-03-7
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Anticancer agent 90 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor activity. Anticancer agent 90 has high inhibition against the two cell line from ovarian cancer (OVCAR-4), renal cancer (A498) .
Cat. No.: HY-151592
CAS No.: 2977251-00-4
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Anticancer agent 91 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. Anticancer agent 91 has high inhibition against the two cell line from CNS cancer (SF-539 and SNB-75) .
Cat. No.: HY-151587
CAS No.: 2977251-05-9
Anticancer agent 89 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor activity, has high inhibition against the three cell line from ovarian cancer (OVCAR-4), renal cancer (A498), and melanoma (SK-MEL-5) .
Cat. No.: HY-W159102
CAS No.: 40106-14-7
8CN, a 2-amino-thiophene derivative, has anti-leishmanial activity. 8CN can be used in research of Leishmaniasis .
Cat. No.: HY-151589
CAS No.: 2977251-02-6
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HCVcc-IN-2 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. HCVcc-IN-2 has high inhibition against the three cell line from CNS cancer (SF-539 and SNB-75), colon cancer (HCT-116), and renal cancer (A498) .
Cat. No.: HY-117817
CAS No.: 135459-90-4
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Ranelic acid is an organic acid with metal cation chelating activity. Ranelic acid can be used to inhibit osteoporosis and increase bone mineral density. Ranelic acid derivatives exhibit highly substituted thiophene ring structures .
Cat. No.: HY-13465A
CAS No.: 914778-92-0
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Research Areas:
VCH-916 free base is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase. VCH-916 free base binds to Thumb Site II. VCH-916 free base can be used for the research of hepatitis c virus (hcv) infection .
Cat. No.: HY-CE01952
Synonyms: thiophene-2-carbonyl-coenzyme A
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Research Areas:
Thiophene-2-carbonyl-CoA (Thiophene-2-carbonyl-coenzyme A) is a coenzyme A derivative .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
