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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
tubulin-binding
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "tubulin-binding" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: CDX-011; CR011-vcMMAE
Research Areas:
Glembatumumab vedotin (CDX-011) is an ADC comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects .
Cat. No.: HY-W021267
CAS No.: 7336-33-6
Category:
Alkaloids other families Monophenols Other Alkaloids Phenols Plants Disease Research Fields Inflammation/Immunology
Target:
Target:
Research Areas:
OXi8007 is a water-soluble phosphate proagent of OXi8006, a tubulin-binding compound.
Cat. No.: HY-N7256
CAS No.: 159001-25-9
Category:
Other Terpenoids Terpenoids Plants Cephalotaxaceae Disease Research Fields Cancer Cephalotaxus fortunei Hooker
Target:
Cat. No.: HY-172915
CAS No.: 2531685-87-5
p53 Stabilizer 2 is a 9'-cycloheptylselenomethyl-noscapine derivative and DNA-PKcs-dependent p53 stabilizer with low tubulin-binding affinity.p53 Stabilizer 2 induces S-phase arrest and apoptosis in cancer cells.p53 Stabilizer 2 can be used for the research of cancer .
Cat. No.: HY-144585
CAS No.: 1835700-14-5
Target:
Research Areas:
AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10 . AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-183147A
Target:
Research Areas:
LAT1-IN-2 hydrochloride is an orally active anticancer agent, as well as a LAT1 substrate and tubulin-binding agent. LAT1-IN-2 hydrochloride relies on LAT1 for cellular uptake, disrupts microtubule formation by binding to the colchicine site of tubulin, and induces actin depolymerization to transform cells into a spherical shape. LAT1-IN-2 hydrochloride effectively inhibits tumor growth in xenograft mice. Compared with Etoposide (HY-13629), LAT1-IN-2 hydrochloride shows higher distribution in tumor tissues, lower distribution in major organs, and better tolerability. LAT1-IN-2 hydrochloride has been applied in studies related to esophageal cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
