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Pathways Recommended: Protein Tyrosine Kinase/RTK MAPK/ERK Pathway
Results for "

tyrosine degradation pathway

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Inhibitory Antibodies

1

Natural
Products

Targets Recommended:
Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-W010040
    4-​Hydroxyphenylpyruvic acid
    1 Publications Verification

    		 Endogenous Metabolite Cardiovascular Disease Metabolic Disease
    4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase (HPPA). 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria .
    4-​Hydroxyphenylpyruvic acid
  • HY-153896
    LMTK3-IN-1
    1 Publications Verification

    		 c-Met/HGFR Cancer
    LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM .
    LMTK3-IN-1
  • HY-179562
    BTK degrader-2

    		Btk Cancer
    BTK degrader-2 (Example 2) is a BTK dual-functional degrading agent, which causes the degradation of BTK through the ubiquitin-proteasome pathway. BTK degrader-2 can be used for the study of B-cell-related diseases .
    BTK degrader-2
  • HY-P992396
    KTN0073

    		c-Met/HGFR Cancer
    KTN0073 is a high-affinity MET receptor tyrosine kinase inhibitor. KTN0073 can be used in studies related to non-small cell lung cancer and human cancers driven by HGF, MET amplification, or exon 14 mutation. KTN0073 binds to the Sema/PSI domain to block the HGF-MET interaction, and induces ubiquitination and degradation of oncogenic MET receptors via an HGF-independent pathway, thereby inhibiting MET-dependent signal transduction. KTN0073 exhibits significant antitumor activity in vivo, and its tumor suppressive activity is superior to that of the IgG1 subtype when grafted to the IgG2 constant region .
    KTN0073
  • HY-W753209
    Tolpyralate

    		Herbicide HPPD Others
    Tolpyralate is a selective post-emergence herbicide and corn Herbicide. Tolpyralate inhibits 4-HPPD. Tolpyralate exhibits herbicidal activity against a variety of weeds, including the glyphosate-resistant weed Amaranthus tuberculatus .
    Tolpyralate

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