2655638-07-4
Chemical Structure
PROTAC PTPN2 degrader-1
- CAS No.: 2655638-07-4
- Formula:C33H27FN6O8S
- Molecular Weight:686.67
IUPAC Name: ethyl (E)-3-(4-iodophenyl)acrylate
InChIKey: SVEZXFBVLPICRX-UHFFFAOYSA-N
SMILES: O=C(CC1=CC=C(C2=CC(N(C)C(N3C4C(NC(CC4)=O)=O)=O)=C3C=C2)C=C1)NC5=CC6=CC(O)=C(N7CC(NS7(=O)=O)=O)C(F)=C6C=C5
Biological Activity: PROTAC PTPN2 degrader-1 is a PROTAC degrader targeting non-receptor protein tyrosine phosphatase 2 (PTPN2), with a DC50 of 18 nM in 293T cells. It exhibits an IC50 of 22 nM against PTPN2. Through highly selective degradation and inhibition of PTPN2 phosphatase, PROTAC PTPN2 degrader-1 relieves the negative regulation of the IFNγ pathway, upregulates interferon signaling, activates effector T cells, and enhances anti-tumor immunity. PROTAC PTPN2 degrader-1 can be used in melanoma-related research[1].
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PROTAC PTPN2 degrader-1 | PROTAC PTPN2 degrader-1 is a PROTAC degrader targeting non-receptor protein tyrosine phosphatase 2 (PTPN2), with a DC50 of 18 nM in 293T cells. It exhibits an IC50 of 22 nM against PTPN2. Through highly selective degradation and inhibition of PTPN2 phosphatase, PROTAC PTPN2 degrader-1 relieves the negative regulation of the IFNγ pathway, upregulates interferon signaling, activates effector T cells, and enhances anti-tumor immunity. PROTAC PTPN2 degrader-1 can be used in melanoma-related research. | |||||||||||||||||||||
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