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Results for "

ubiquitin

" in MedChemExpress (MCE) Product Catalog:

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BAY 11-7082 Maximum Cited Publications 450 Publications Verification BAY 11-7821	IKK Deubiquitinase Autophagy Apoptosis NF-κB	Inflammation/Immunology Cancer
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .

Arimoclomol maleate 5 Publications Verification BRX-220	HSP	Neurological Disease Metabolic Disease Inflammation/Immunology
Arimoclomol maleate (BRX-220) is an orally active co-inducer of heat shock proteins (HSP) . Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system .Arimoclomol maleate can be used for the study of Niemann–Pick disease type C.

AGX51 5+ Cited Publications	DNA/RNA Synthesis DNA Alkylator/Crosslinker	Cancer
AGX51 is the first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. AGX51 inhibits Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and viability reduction. AGX51 can inhibit TNBC and has an IC₅₀ of about 25 nM. AGX51 can be used in cancer research.

KL001 2 Publications Verification	Cryptochrome	Metabolic Disease
KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis .

Arimoclomol 5 Publications Verification BRX-220 free base	HSP	Neurological Disease Metabolic Disease Inflammation/Immunology
Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol can be used for the study of Niemann–Pick disease type C. Arimoclomol can cross the blood-brain barrier and can be used in research on Niemann-Pick disease type C .

Navitoclax-piperazine ABT-263-piperazine	Ligands for Target Protein for PROTAC Bcl-2 Family	Cancer
Navitoclax-piperazine (ABT-263-piperazine) is a Navitoclax (HY-10087) analog and BCL-XL inhibitor. Navitoclax-piperazine is the ligand for target protein of PROTAC DT2216 (HY-130604). Navitodax-pperaie and E3 ubiquitin ligase VHL ligand can be used to synthesize PROTAC DT2216 (HY-130604) .

DC-U4106 1 Publications Verification	Deubiquitinase Apoptosis	Cancer
DC-U4106 is a USP8 targeting inhibitor with the K_dvalue of 4.7 μM and the IC₅₀ value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer .

TCID 5+ Cited Publications 4,5,6,7-Tetrachloroindan-1,3-dione	Deubiquitinase	Neurological Disease
TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective *neuronal ubiquitin* C-terminal hydrolase (UCH-L3) inhibitor with an IC₅₀** of 0.6 μM . TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons .

Arimoclomol citrate 5 Publications Verification BRX-220 citrate	HSP	Neurological Disease Metabolic Disease Inflammation/Immunology
Arimoclomol citrate (BRX-220 citrate) is an orally active co-inducer of heat shock proteins (HSP) . Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system . Arimoclomol citrate can be used for the study of Niemann–Pick disease type C.

NVS-VHL720	Molecular Glues	Cancer
NVS-VHL720 is a selective VHL-based cysteine dioxygenase (CDO1) molecular glue degrader. NVS-VHL720 recruits CDO1 to the VHL E3 ligase complex, driving ubiquitin-dependent proteasomal degradation of CDO1. NVS-VHL720 can be used for the research of cancer .

RJS308	PROTACs Cyclophilin HIV HCV	Infection
RJS308 is a selective Cyclophilin A (CypA) PROTAC degrader. RJS308 induces ubiquitin-dependent CypA degradation by recruiting the VHL E3 ligase complex, and forms a ternary complex with CypA and VHL/elongin C/elongin B. RJS308 exhibits anti-HIV-1 and anti-HCV activities. RJS308 can be used in studies related to viral infections .

FT206 1 Publications Verification	Deubiquitinase	Cancer
FT206 is the inhibitor for ubiquitin-specific protease that inhibits USP28 and USP25 with IC₅₀s of 0.15 μM and 1.01 μM .

Ubiquitin Isopeptidase Inhibitor I, G5 5+ Cited Publications NSC144303	Apoptosis	Cancer
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC₅₀ values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

MAK683-C2-acid hydrochloride	Ligands for Target Protein for PROTAC Histone Methyltransferase	Cancer
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615) .

NSC2805 1 Publications Verification	E1/E2/E3 Enzyme	Cancer
NSC2805 is a *WWP2 ubiquitin* ligase inhibitor that can significant inhibit WWP2 activity with an IC₅₀** of 0.38 μM. NSC2805 can be used for the research of cancer .

EN450	NF-κB Molecular Glues E1/E2/E3 Enzyme	Cancer
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the *E2 ubiquitin* ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase** and proteasome-dependent mechanism .

UT-34	Estrogen Receptor/ERR	Endocrinology Cancer
UT-34 is a potent, selective, orally bioactive second-generation pan-androgen receptor (AR) antagonist and degrader, with IC₅₀ values of 211.7 nM, 262.4 nM, and 215.7 nM for wild-type AR, F876L-AR, and W741L-AR, respectively. UT-34 binds to the ligand-binding domain (LBD) and functional 1 (AF-1) domain of AR and requires the ubiquitin-proteasome pathway for AR degradation. UT-34 has anti-prostate cancer effects.

SMER3	E1/E2/E3 Enzyme	Cancer
SMER3, a Rapamycin enhancer, is a selective *Skp1-Cullin-F-box (SCF) ^Met30 ubiquitin* ligase** inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCF ^Met30 .

(S)-ACE-OH	Molecular Glues	Cancer
(S)-ACE-OH is a molecular glue with anticancer activity. (S)-ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98 .

SIAIS178	PROTACs Bcr-Abl	Cancer
SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC₅₀ of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity .

UC-764864	E1/E2/E3 Enzyme Apoptosis	Cancer
UC-764864 is a selective UBE2N inhibitor. UC-764864 covalently binds UBE2N catalytic Cys87, blocks ubiquitin-UBE2N thioester formation and polyubiquitin chain synthesis. UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates, and induces cell apoptosis. UC-764864 can be used for the research of acute myeloid leukemia .

TMX1	Molecular Glues Epigenetic Reader Domain	Cancer
TMX1 is a covalent, selective BRD4 molecular glue degrader. TMX1 binds to the JQ1-binding site of BRD4BD2, forms covalent bonds with Cys58 of DCAF16 and Cys87 of GAK in a BRD4BD2-dependent template-assisted manner, stabilizes the BRD4-TMX1-DCAF16 ternary complex, and promotes the ubiquitination of BRD4 via the CRL4_DCAF16 ubiquitin ligase complex. TMX1 induces selective degradation of BRD4, mild degradation of BRD2 and BRD3, as well as DCAF16-dependent cytotoxicity .

NSC624206	E1/E2/E3 Enzyme	Cancer
NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC₅₀ of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC₅₀=13 μM) but has no effect on ubiquitin adenylation .

LDN-91946	Deubiquitinase	Neurological Disease Cancer
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a K_{i app} of 2.8 μM .

HOIPIN-1 3 Publications Verification JTP-0819958	IKK	Cancer
HOIPIN-1 (JTP-0819958) is a selective *linear ubiquitin* chain assembly complex (LUBAC) inhibitor with an IC₅₀** of 2.8 μM . HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro .

Thalidomide-Piperazine 5-fluoride hydrochloride	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis .

Nrf2 activator-10	Keap1-Nrf2 Apoptosis	Cancer
Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC₅₀ is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H₂O₂-induced apoptosis.

Physalin B	Apoptosis Autophagy	Cancer
Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro .

Lenalidomide-Br	Ligands for E3 Ligase	Cancer
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602) .

HLI373 dihydrochloride	MDM-2/p53 Parasite Apoptosis	Infection Cancer
HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents . Antimalarial activity .

Lenalidomide-propargyl-C2-NH2 hydrochloride 1 Publications Verification	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312) . Lenalidomide-propargyl-C2-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

SPOP-IN-1	Akt ERK E1/E2/E3 Enzyme	Cancer
SPOP-IN-1 is a selective *SPOP E3 ubiquitin* ligase inhibitor. SPOP-IN-1 leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK** in clear-cell renal cell carcinoma .

RNF5 inhibitor inh-02	E1/E2/E3 Enzyme Atg8/LC3	Inflammation/Immunology
RNF5 inhibitor inh-02 is a potent inhibitor of *E3 ubiquitin* ligase RNF5/RMA1. RNF5 inhibitor inh-02 rescues F508del-CFTR function in F508del-CFTR-expressing immortalized cells (CFBE41o⁻, EC₅₀ = 2.6 μM; FRT, EC ₅₀ = 2.2 μM). RNF5 inhibitor inh-02 increases LC3IIB expression and autophagic vacuole number via reducing ATG4B** ubiquitylation and promotes cell motility. RNF5 inhibitor inh-02 can be used for the study of cystic fibrosis .

PROTAC USP7 Degrader-1	PROTACs Deubiquitinase	Cancer
PROTAC USP7 Degrader-1 is a VHL-recruiting PROTAC and USP7 degrader with binding activity to both USP7 and the VHL E3 ubiquitin ligase. PROTAC USP7 Degrader-1 recruits the VHL E3 ligase to mediate the ubiquitination and subsequent proteolytic degradation of USP7 .

Cereblon inhibitor 1	Ligands for E3 Ligase	Cancer
Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating agent. Cereblon inhibitor 1 has the potential for cancer research.

BC-1382	E1/E2/E3 Enzyme	Inflammation/Immunology
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction (IC₅₀≈ 5 nM).Anti-inflammatory activity .

BWA-522 intermediate-1	Ligands for E3 Ligase	Cancer
BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 (HY-149433) and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7 .

ITK degrader 2	PROTACs Itk	Inflammation/Immunology Cancer
ITK degrader 2 is an orally active ITK PROTAC degrader with a DC₅₀ < 0.001 nM. ITK degrader 2 degrades ITK via the ubiquitin-proteasome pathway. ITK degrader 2 can be used in the research of cancer, autoimmune diseases and inflammatory diseases .

8RK59	Deubiquitinase	Cancer
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC₅₀ close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 .

WH-10417-099	PROTACs Casein Kinase	Cancer
WH-10417-099 is a CRBN-based PROTAC multi-kinase degrader that induces the degradation of the maximum number of unique kinases (over 125 unique kinases, such as CSNK1E and PI3Kγ) simultaneously. WH-10417-099 induces protein degradation via the ubiquitin biotinylation (E-STUB) pathway, exhibits synergistic effects with SB-405483 (HY-W1135319). The E3 ligase ligand and linker of WH-10417-099 can form the conjugate Pomalidomide 4'-PEG5-acid (HY-131647) .

RAMB4 1 Publications Verification	Proteasome	Cancer
RAMB4 is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity .

PROTAC K-Ras Degrader-7	PROTACs Ras Keap1-Nrf2	Cancer
PROTAC K-Ras Degrader-7 is a potent PROTAC K-Ras degrader. PROTAC K-Ras Degrader-7 degrades K-Ras through recruiting the Keap1 E3 ubiquitin ligase. PROTAC K-Ras Degrader-7 can be used for research in pancreatic and colorectal cancers .

MAK683-CH2CH2COOH	Histone Methyltransferase Ligands for Target Protein for PROTAC	Cancer
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615) .

HLI373	MDM-2/p53 Parasite Apoptosis	Infection Cancer
HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents . Antimalarial activity .

PROTAC SMARCA2 degrader-1	Target Protein Ligand-Linker Conjugates	Cancer
PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC₅₀<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate .

VHL Ligand-Linker Conjugates 17	E3 Ligase Ligand-Linker Conjugates	Cancer
VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader . VHL Ligand-Linker Conjugates 17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name

HY-L050

Ubiquitination Compound Library

482 compounds

Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.

MCE offers a unique collection of 482 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

HY-L934

CRBN Ligand Library

125 compounds

CRBN, namely cereblon, is the substrate recognition subunit of the E3 ubiquitin ligase complex in the ubiquitin-proteasome system. A CRBN ligand library refers to a collection of numerous fragments that can specifically bind to the CRBN protein.

These ligands are mostly designed based on validated CRBN-binding warheads and modified through AI-driven molecular generation optimization systems. They not only include classic lenalidomide-derived structures but also cover novel non-lenalidomide scaffolds. After drug-likeness filtering, these ligands exhibit structural diversity and favorable druggable properties. They can be further optimized and modified to facilitate the development of novel molecular glue degraders, accelerate the discovery of molecular glues that induce interactions between CRBN and new substrate proteins, and enable the exploration of novel CRBN substrates for identifying previously unknown CRBN-binding proteins.

MCE compiles 125 fragments that can specifically bind to the CRBN protein, with molecular weights ranging from 200 to 500. Compounds developed based on the library ligands target multiple disease targets such as cancer and autoimmune diseases, further advancing the development of Molecular Glues and PROTACs therapeutic agents.

HY-L151

PROTAC Library

515 compounds

PROTACs (Proteolysis-targeting chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy.

MCE supplies a unique collection of 515 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc.

HY-L180

Mitophagy Compound Library

601 compounds

Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms.

MCE can provide a library of 601 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

HY-L128

E3 Ligase Ligand Library

174 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation.

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 174 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L918

Molecular Glue-like Compound Library

317 compounds

Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms.

Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases.

Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 317 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

HY-L935

Molecular Glue POI binding Fragment library

1039 compounds

POI (Protein of Interest) refers to the target protein, namely the disease-causing protein or key functional protein that undergoes degradation or functional modulation in molecular glue-mediated processes. The Molecular Glue POI Library consists of a series of fragments that can specifically bind to different types of POIs. As key components of molecular glues, these ligands form stable interactions with target proteins, laying the foundation for molecular glues to induce the interaction between POIs and E3 ubiquitin ligases. The covered POIs include various types such as cancer-associated GSPT1, androgen receptors, and abnormally aggregated proteins linked to neurodegenerative diseases.

This fragment library can be applied to the screening and optimization of targeted protein degraders. By screening ligands with high affinity and strong selectivity for specific POIs from the library, core structures can be identified to develop novel molecular glues. For instance, optimization of ligands targeting GSPT1 has yielded molecular glue degraders with enhanced degradation activity. Since many POIs are difficult to drug due to the lack of traditional small-molecule binding pockets, some ligands in the POI Ligand Library can modulate such POIs by inducing protein-protein interactions, thereby further expanding the scope of drug discovery for undruggable targets.

MCE has compiled a POI Fragment Library comprising thousands of POI fragments with molecular weights ranging from 150 to 400. This compound library can be widely applied in Molecular Glue research and development.

Cat. No.	Product Name	Type

HY-D2912

Cys-shift probe-1	Fluorescent Dyes
Cys-shift probe-1 (compound 13) is a potent Cys-shift probe. Cys-shift probe-1 can improve the ion mobility of labeled peptides and be used in protein analysis .

HY-D1726

8RK59	Fluorescent Dyes
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC₅₀ close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 .

HY-N2306R

Aclacinomycin A (Standard)

Aclarubicin (Standard)

Fluorescent Dyes

Aclacinomycin A (Standard) is the analytical standard of Aclacinomycin A. This product is intended for research and analytical applications. Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

Cat. No.	Product Name	Type

HY-135484

NDSB-195	Biochemical Assay Reagents
NDSB-195 is protein stabilizer that enhances the dynamics of the β4-α2 loop of ubiquitin. NDSB-195 stabilizes Saccharomyces cerevisiae ubiquitin against guanidium chloride denaturation, increasing the onset temperature of heat denaturation in the presence of the denaturant .

Cat. No.	Product Name	Target	Research Area

HY-P10899

ETTAC-2	PROTACs TGF-beta/Smad	Endocrinology
ETTAC-2 is a LRG1 PROTAC degrader, degrading LRG1 via the ubiquitin-proteasome pathway with a DC₅₀ value of 8.38 μM. ETTAC-2 penetrates damaged renal cells to reduce the extracellular secretion of LRG1. ETTAC-2 effectively inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated extracellular matrix proteins. ETTAC-2 degrades LRG1 within fibrotic kidneys and the efficacy in inhibiting the TGF-β-Smad3 pathway both in vitro and vivo. ETTAC-2 can be used for renal fibrosis research .

HY-P10412

A11 ANXA1-derived 11 amino acid-long peptide	Ephrin Receptor Annexin A	Cancer
A11 (ANXA1-derived 11 amino acid-long peptide) is a ANXA1-EphA2 interaction-blocking peptide. A11 reduces ANXA1 bound to EphA2 and increases Cbl (the E3 ubiquitin ligase of EphA2) bound to EphA2. A11 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma cells. A11 inhibits angiogenesis. A11 can be used in studies related to nasopharyngeal carcinoma .

HY-P11228

FPP29	PROTACs Apoptosis DNA/RNA Synthesis	Cancer
FPP29 is a potent peptide-based FOXM1 PROTAC degrader. FPP29 induces ubiquitination and degradation of FOXM1. FPP29 inhibits FOXM1 via the ubiquitin-proteasome degradation pathway. FPP29 induces Apoptosis. FPP29 suppresses tumor growth in hepatocellular carcinoma xenograft models. FPP29 can be used in the research of hepatocellular carcinoma (cell-penetrating peptide: (HY-P0133); VHL ligase ligand: (HY-P11493); linker: (HY-W013664); FOXM1 ligand: (HY-P11494)) .

HY-P1259A

PR-39 TFA	Proteasome Bacterial	Inflammation/Immunology
PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-P2483B

Octaarginine acetate	Bacterial Proteasome	Infection Inflammation/Immunology Cancer
Octaarginine acetate is a cell-penetrating peptide and proteasome inhibitor. Octaarginine acetate exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine acetate induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine acetate can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P2483

Octaarginine	Proteasome Bacterial	Infection Inflammation/Immunology Cancer
Octaarginine is a cell-penetrating peptide and proteasome inhibitor. Octaarginine exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P11020

p27 Analogue CP2	E1/E2/E3 Enzyme	Cancer
p27 Analogue CP2 is a macrocyclic peptide inhibitor targeting the Cks1-Skp2-Skp1 complex (K_d = 32 nM). p27 Analogue CP2 blocks SCFSkp2/Cks1-mediated ubiquitylation and degradation of p27, restoring p27 levels and inhibiting cell proliferation. p27 Analogue CP2 is promising for research of cancers dependent on Skp2 overexpression such as breast cancer .

HY-P1259

PR-39	Proteasome Bacterial	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-P11493

ALAPYIP	Ligands for E3 Ligase	Cancer
ALAPYIP is a ligand for E3 ligase. ALAPYIP recruits the VHL-E3 ubiquitin ligase. ALAPYIP can be used for the synthesis of FPP29 (HY-P11228) .

HY-P10981

ErbB2 peptide	PI3K Ligands for E3 Ligase	Cancer
ErbB2 peptide is a peptide ligand of E3 ubiquitin ligase targeting PI3K for peptide PROTACs .

HY-P10416

Q14 Q14 peptide	Deubiquitinase Mitophagy	Others Neurological Disease
Q14 is a polypeptide derived from the USP30 (ubiquitin specific peptidase 30) transmembrane (TM) domain with the ability to inhibit the deubiquitination activity of USP30 (IC₅₀=57.2 nM). Q14 reduces USP30 activity by inhibiting the interaction between the USP30 transmembrane domain and its catalytic domain. Q14 peptide contains the LC3 interaction region (LIR) motif, which enables it to bind to the LC3 and accelerate the formation of autophagosomes, thereby promoting mitophagy. Q14 can be used in the study of neurodegenerative diseases as well as mitochondrial quality control and cell metabolism .

HY-P3830

Beacon (30-73)	Peptides	Metabolic Disease
Beacon (30-73) is an ubiquitin-like protein, consisting of 44 amino acids .

HY-P4095

NoxaBH3	CXCR	Cancer
NoxaBH3 is a cysteine-based cross-linked peptide with increased cell permeability and higher inhibitory activity against Mcl-1. NoxaBH3 binds to the endogenous CXCR4 ligand to produce ubiquitin-Noxabh3 conjugate. NoxaBH3 is then delivered to cancer cells .

HY-P2483A

Octaarginine TFA	Proteasome Bacterial	Infection Neurological Disease Cancer
Octaarginine TFA is a cell-penetrating peptide and proteasome inhibitor. Octaarginine TFA exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine TFA induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine TFA can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P11631

Arg12	Ligands for E3 Ligase	Cancer
Arg12, a 12-amino acid peptide sequence, is an E3 ubiquitin ligase ligand. Arg12 can be used to synthesize PROTACs, such as PROTAC PLK1 Degrader-2 (HY-180989). Arg12 can also act as a cell transmembrane peptide (CPP), facilitating the entire molecule to enter the cell .

HY-P11792

CP2-CPP	E1/E2/E3 Enzyme	Cancer
CP2-CPP is a conjugate of p27 Analogue CP2 (HY-P11020) and Antennapedia Peptide (HY-P0307). CP2-CPP crosses cell membranes and localizes to live cell cytosol. CP2-CPP blocks SCF ^Skp2/Cks1-p27 interaction to inhibit p27 ubiquitination and degradation, restoring p27 levels and inhibiting cell proliferation. CP2-CPP can be used for the research of cancer, such as breast cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9S0124

Anti-CD33 Antibody (OR000283) ORM-6151 Antibody; BMS-986497 Antibody		Cancer
Anti-CD33 Antibody (OR000283) (ORM-6151 Antibody; BMS-986497 Antibody) is an antibody targeting CD33. It is generated by grafting the FAb (H&L) sequence of Gemtuzumab (HY-P99971) onto an IgG1 Fc carrying the N297A mutation, which inhibits Fc-γR binding. Anti-CD33 Antibody (OR000283) can be used to construct degrader-antibody conjugates (DACs), such as ORM-6151 (HY-171792) .

Species:	Human (210) Mouse (10) Rat (2) Xenopus laevis (1)
Tag:	SUMO (5) His (112) Strep (19) Tag Free (74) Avi (1) Myc (2) GST (32) HA (1) Fc (3) Flag (6)
Source:	HEK293 (9) E. coli Cell-free (4) sf9 insect cells (2) P. pastoris (2) Sf9 insect cells (74) E. coli (133)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705992

	ubiquitin Protein, Human (HA) ubiquitin; ubiquitin-associated domain-containing protein 2; UBA domain-containing protein 2; Phosphoglycerate dehydrogenase-like protein 1; UBAC2; PHGDHL1; PSEC0110	Human	E. coli
	Ubiquitin is a multifunctional protein that can form covalently linked isopeptide bonds in various states, including mono- and polyubiquitin chains. ubiquitin Protein, Human (HA) is the recombinant human-derived ubiquitin protein, expressed by E. coli , with N-HA labeled tag.

HY-P71402

	UBE2H Protein, Human (GST) ubiquitin-Conjugating Enzyme E2 H; UbcH2; ubiquitin Carrier Protein H; ubiquitin-Conjugating Enzyme E2-20K; ubiquitin-Protein Ligase H; UBE2H	Human	E. coli
	UBE2H Protein, a crucial participant in cellular ubiquitination, transfers ubiquitin from the E1 complex to various proteins, including MAEA of the CTLH E3 ubiquitin-protein ligase complex. Versatile in vitro, UBE2H catalyzes both 'Lys-11'- and 'Lys-48'-linked polyubiquitination, showcasing its involvement in diverse ubiquitin-related processes. Notably, it demonstrates the capability to ubiquitinate histone H2A in vitro. UBE2H Protein, Human (GST) is the recombinant human-derived UBE2H protein, expressed by E. coli , with N-GST labeled tag.

HY-P701494

	UBE2O Protein, Human (sf9) UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme; E2/E3 hybrid ubiquitin-protein ligase UBE2O; ubiquitin carrier protein O; ubiquitin-conjugating enzyme E2 O; ubiquitin-conjugating enzyme E2 of 230 kDa; ubiquitin-conjugating enzyme E2-230K; ubiquitin-protein ligase O	Human	Sf9 insect cells
	UBE2O protein acts as a hybrid E2/E3 ubiquitin protein ligase capable of monoubiquitinating target proteins. It negatively regulates TRAF6-mediated NF-kappa-B activation independently of E2 activity. UBE2O Protein, Human (sf9) is the recombinant human-derived UBE2O protein, expressed by sf9 insect cells , with tag free.

HY-P701493

	UBE2O Protein, Human (sf9, His, StrepⅡ) UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme; E2/E3 hybrid ubiquitin-protein ligase UBE2O; ubiquitin carrier protein O; ubiquitin-conjugating enzyme E2 O; ubiquitin-conjugating enzyme E2 of 230 kDa; ubiquitin-conjugating enzyme E2-230K; ubiquitin-protein ligase O	Human	Sf9 insect cells
	UBE2O protein acts as a hybrid E2/E3 ubiquitin protein ligase capable of monoubiquitinating target proteins. It negatively regulates TRAF6-mediated NF-kappa-B activation independently of E2 activity. UBE2O Protein, Human (sf9, His, Strep) is the recombinant human-derived UBE2O protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P71408

	UBE2S Protein, Human (GST) ubiquitin-Conjugating Enzyme E2 S; E2-EPF; ubiquitin Carrier Protein S; ubiquitin-Conjugating Enzyme E2-24 kDa; ubiquitin-Conjugating Enzyme E2-EPF5; ubiquitin-Protein Ligase S; UBE2S; E2EPF	Human	E. coli
	The UBE2S protein is critical in cellular ubiquitination, accepting ubiquitin from the E1 complex and catalyzing covalent attachment to various proteins.UBE2S is a key contributor to cell cycle regulation, catalyzing "Lys-11"-linked polyubiquitination, which is critical for anaphase-promoting complex/cyclosome (APC/C) function.UBE2S Protein, Human (GST) is the recombinant human-derived UBE2S protein, expressed by E.coli , with N-GST labeled tag.

HY-P71405

	UBE2K Protein, Human (GST) ubiquitin-Conjugating Enzyme E2 K; Huntingtin-Interacting Protein 2; HIP-2; ubiquitin Carrier Protein; ubiquitin-Conjugating Enzyme E2-25 kDa; ubiquitin-Conjugating Enzyme E2(25K); ubiquitin-Conjugating Enzyme E2-25K; ubiquitin-Protein Ligase; UBE2K; HIP2; LIG	Human	E. coli
	UBE2K protein is an important component of the ubiquitin-proteasome system and functions as an E2 ubiquitin-conjugating enzyme, which is critical for attaching ubiquitin to different substrates. In vitro, UBE2K catalyzes "Lys-48" linked polyubiquitin chains, specifically in the presence or absence of the BRCA1-BARD1 E3 ligase complex. UBE2K Protein, Human (GST) is the recombinant human-derived UBE2K protein, expressed by E. coli , with N-GST labeled tag.

HY-P79457

	USP2 Catalytic Domain Protein, Human (His) ubiquitin Specific Peptidase 2; UBP41; ubiquitin-Specific-Processing Protease 2; ubiquitin Carboxyl-Terminal Hydrolase 2; 41 KDa ubiquitin-Specific Protease; Deubiquitinating Enzyme 2; ubiquitin-specific Protease 2	Human	E. coli
	USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Catalytic Domain Protein, Human (His) is the recombinant human-derived USP2 Catalytic Domain protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701350

	UBE2C Protein, Human (sf9, His, StrepⅡ) UBE2C; ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C; E2 ubiquitin-conjugating enzyme C; UbcH10; ubiquitin carrier protein C; ubiquitin-protein ligase C	Human	Sf9 insect cells
	The UBE2C protein is a key ubiquitin-proteasome system component that acts as an E2 ubiquitin-conjugating enzyme and is the core of the covalent linkage of ubiquitin to target proteins. In vitro, UBE2C expertly promotes “Lys-11” and “Lys-48” linked polyubiquitination, demonstrating the versatility of ubiquitin chain formation. UBE2C Protein, Human (sf9, His, Strep) is the recombinant human-derived UBE2C protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701422

	USP48 Protein, Human (sf9, FLAG) USP48; ubiquitin carboxyl-terminal hydrolase 48; Deubiquitinating enzyme 48; ubiquitin thioesterase 48; ubiquitin-specific peptidase 48; ubiquitin-specific protease 48; ubiquitin-specific-processing protease 48	Human	Sf9 insect cells
	USP48 protein, a deubiquitinase, hydrolyzes ubiquitin bonds at the C-terminal Gly, processing poly-ubiquitin precursors and ubiquitinated proteins. It may regulate NF-kappa-B activation by the TNF receptor superfamily via RELA and TRAF2 interactions. With potential roles at postsynaptic sites, USP48 exhibits multifunctionality, influencing ubiquitin processing and signaling pathways involved in immune response and synaptic function. USP48 Protein, Human (sf9, FLAG) is the recombinant human-derived USP48 protein, expressed by sf9 insect cells , with C-Flag labeled tag.

HY-P701487

	UB2E3 Protein, Human (sf9) UBE2E3; ubiquitin-conjugating enzyme E2 E3; E2 ubiquitin-conjugating enzyme E3; UbcH9; ubiquitin carrier protein E3; ubiquitin-conjugating enzyme E2-23 kDa; ubiquitin-protein ligase E3	Human	Sf9 insect cells
	UB2E3 protein is a key ubiquitin-proteasome system component. As an E2 ubiquitin-conjugating enzyme, it plays a crucial role in the attachment of ubiquitin to target proteins. In vitro, UB2E3 exhibits diverse catalytic abilities, promoting polyubiquitination of “Lys-11,” “Lys-48,” and “Lys-63” linkages, suggesting its involvement in diverse cellular processes. UB2E3 Protein, Human (sf9) is the recombinant human-derived UB2E3 protein, expressed by sf9 insect cells , with tag free.

HY-P701495

	UB2Q2 Protein, Human (sf9) UBE2Q2; ubiquitin-conjugating enzyme E2 Q2; E2 ubiquitin-conjugating enzyme Q2; ubiquitin carrier protein Q2; ubiquitin-protein ligase Q2	Human	Sf9 insect cells
	The UB2Q2 protein is a component of the ubiquitin-proteasome system and functions as an E2 ubiquitin-conjugating enzyme, adept at accepting ubiquitin from the E1 complex and catalyzing its covalent attachment to a variety of protein substrates. In vitro, UB2Q2 efficiently mediates “Lys-48”-linked polyubiquitination. UB2Q2 Protein, Human (sf9) is the recombinant human-derived UB2Q2 protein, expressed by sf9 insect cells , with tag free.

HY-P701406

	UCHL5 Protein, Human UCHL5; ubiquitin carboxyl-terminal hydrolase isozyme L5; UCH-L5; ubiquitin C-terminal hydrolase UCH37; ubiquitin thioesterase L5	Human	E. coli
	UCHL5 is a highly specific protease that acts as a deubiquitinating enzyme intricately linked to the 19S proteasome subunit, cleaving "Lys-48" linked polyubiquitin chains. Although the INO80 complex is inert, transient interactions between INO80 and the proteasome (facilitated by ADRM1) activate UCHL5. UCHL5 Protein, Human is the recombinant human-derived UCHL5 protein, expressed by E. coli , with tag free.

HY-P701349

	USP2 Catalytic Domain Protein, Human USP2; ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; ubiquitin thioesterase 2; ubiquitin-specific-processing protease 2	Human	E. coli
	USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Protein, Human is the recombinant human-derived USP2 protein, expressed by E. coli , with tag free.

HY-P701413

	USP16 Protein, Human (sf9) USP16; ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; ubiquitin thioesterase 16; ubiquitin-processing protease UBP-M; ubiquitin-specific-processing protease 16	Human	Sf9 insect cells
	The USP16 protein is a specific deubiquitinase that targets "Lys-120" of histone H2A (H2AK119Ub), a tag associated with epigenetic transcriptional repression. By catalytically removing this ubiquitin moiety, USP16 acts as a coactivator, promoting subsequent phosphorylation of histone H3 (H3S10ph) 'Ser-11' to achieve mitotic chromosome segregation. USP16 Protein, Human (sf9) is the recombinant human-derived USP16 protein, expressed by sf9 insect cells , with tag free.

HY-P703651

	USP8 Protein, Human (sf9) ubiquitin carboxyl-terminal hydrolase 8; Deubiquitinating enzyme 8; ubiquitin isopeptidase Y (hUBPy); ubiquitin thioesterase 8; ubiquitin-specific-processing protease 8; KIAA0055; UBPY	Human	Sf9 insect cells
	USP8 is a key hydrolase in cellular regulation and plays a crucial role in protein turnover by efficiently deubiquitinating proteins and preventing degradation. Its activity spans "Lys-48" and "Lys-63" linked ubiquitin chains, highlighting its versatility. USP8 Protein, Human (sf9) is the recombinant human-derived USP8 protein, expressed by Sf9 insect cells, with tag free.

HY-P79451

	UbcH7/UBE2L3 Protein, Human 1 Publications Verification ubiquitin-conjugating enzyme E2 L3; UBE2L3; E2 ubiquitin-conjugating enzyme L3; L-UBC; UbcH7; ubiquitin carrier protein L3; ubiquitin-conjugating enzyme E2-F1; ubiquitin-protein ligase L3; UBCE7	Human	E. coli
	UbcH7/UBE2L3 is a unique ubiquitin-conjugating E2 enzyme that cooperates with HECT-type and RBR family E3 ligases and lacks intrinsic E3-independent reactivity with lysine. It uniquely works with RBR family E3 enzymes such as PRKN, RNF31 and ARIH1, acting like a RING-HECT hybrid. UbcH7/UBE2L3 Protein, Human is the recombinant human-derived UbcH7/UBE2L3 protein, expressed by E. coli , with tag free.

HY-P701490

	UB2E3 Protein, Human (sf9, His, StrepⅡ) UBE2E3; ubiquitin-conjugating enzyme E2 E3; E2 ubiquitin-conjugating enzyme E3; UbcH9; ubiquitin carrier protein E3; ubiquitin-conjugating enzyme E2-23 kDa; ubiquitin-protein ligase E3	Human	Sf9 insect cells
	UB2E3 protein is a key ubiquitin-proteasome system component. As an E2 ubiquitin-conjugating enzyme, it plays a crucial role in the attachment of ubiquitin to target proteins. In vitro, UB2E3 exhibits diverse catalytic abilities, promoting polyubiquitination of “Lys-11,” “Lys-48,” and “Lys-63” linkages, suggesting its involvement in diverse cellular processes. UB2E3 Protein, Human (sf9, His, Strep) is the recombinant human-derived UB2E3 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701488

	UB2E2 Protein, Human (sf9) UBE2E2; ubiquitin-conjugating enzyme E2 E2; E2 ubiquitin-conjugating enzyme E2; UbcH8; ubiquitin carrier protein E2; ubiquitin-protein ligase E2	Human	Sf9 insect cells
	The UB2E2 protein is a key ubiquitin-proteasome system participant, acting as an E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to proteins. In vitro, UB2E2 exhibits multifunctionality by catalyzing polyubiquitination of “Lys-11,” “Lys-48,” and “Lys-63” linkages, suggesting its involvement in diverse cellular processes. UB2E2 Protein, Human (sf9) is the recombinant human-derived UB2E2 protein, expressed by sf9 insect cells , with tag free.

HY-P705707

	SMT3 Protein, Saccharomyces cerevisiae (P. pastoris, His) DmSUMO 1; Small ubiquitin-like modifier; SMT3; SMT3_YEAST; ubiquitin like protein of the SUMO family; ubiquitin like protein SMT3; ubiquitin-like protein SMT3	Others	P. pastoris

HY-P79448

	UBE2R1/CDC34 Protein, Human (sf9, His, StrepII) ubiquitin-conjugating enzyme E2 R1; CDC34; (E3-independent) E2 ubiquitin-conjugating enzyme R1 (EC:2.3.2.24); E2 ubiquitin-conjugating enzyme R1; ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; ubiquitin-protei	Human	Sf9 insect cells
	The UBE2R1/CDC34 protein is an important ubiquitin-proteasome system component that functions as an E2 ubiquitin-conjugating enzyme, capable of proficiently accepting ubiquitin from the E1 complex and catalyzing its covalent attachment to a variety of protein substrates. . In vitro, UBE2R1 efficiently mediates “Lys-48”-linked polyubiquitination. UBE2R1/CDC34 Protein, Human (sf9, His, Strep) is the recombinant human-derived UBE2R1/CDC34 protein, expressed by sf9 insect cells , with N-Strep, N-His labeled tag.

HY-P71401

	UBE2G2 Protein, Human (GST) ubiquitin-Conjugating Enzyme E2 G2; ubiquitin Carrier Protein G2; ubiquitin-Protein Ligase G2; UBE2G2	Human	E. coli
	The UBE2G2 protein is an important ubiquitination component that accepts ubiquitin in the E1 complex, catalyzes its covalent attachment to various proteins, and preferentially performs "Lys-48"-linked polyubiquitination. Its specificity in shaping ubiquitin chains emphasizes its role in cellular processes. UBE2G2 Protein, Human (GST) is the recombinant human-derived UBE2G2 protein, expressed by E. coli , with N-GST labeled tag.

HY-P703652

	USP8 Protein, Human (sf9, His, GST) ubiquitin carboxyl-terminal hydrolase 8; Deubiquitinating enzyme 8; ubiquitin isopeptidase Y (hUBPy); ubiquitin thioesterase 8; ubiquitin-specific-processing protease 8; KIAA0055; UBPY	Human	Sf9 insect cells
	USP8 is a key hydrolase in cellular regulation and plays a crucial role in protein turnover by efficiently deubiquitinating proteins and preventing degradation. Its activity spans "Lys-48" and "Lys-63" linked ubiquitin chains, highlighting its versatility. USP8 Protein, Human (sf9, His, GST) is the recombinant human-derived USP8 protein, expressed by Sf9 insect cells, with N-His and N-GST labeled tag.

HY-P701346

	UbcH6/UBE2E1 Protein, Human (sf9) UBE2E1; ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UbcH6; ubiquitin carrier protein E1; ubiquitin-protein ligase E1	Human	Sf9 insect cells
	The UbcH6/UBE2E1 protein is an important ubiquitination component that acts as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin in the E1 complex and catalyzing its covalent attachment to proteins. It is versatile and also facilitates covalent attachment of ISG15, playing a role in a variety of ubiquitin-like modifications. UbcH6/UBE2E1 Protein, Human (sf9) is the recombinant human-derived UbcH6/UBE2E1 protein, expressed by sf9 insect cells , with tag free.

HY-P702065

	UB2D3 Protein, Human (sf9, His, StrepⅡ) UBE2D3; ubiquitin-conjugating enzyme E2 D3; (E3-independent) E2 ubiquitin-conjugating enzyme D3; E2 ubiquitin-conjugating enzyme D3; ubiquitin carrier protein D3; ubiquitin-conjugating enzyme E2(17)KB 3; ubiquitin-conjugating enzyme E2-17 kDa 3; ubiquitin-protein ligase D3	Human	Sf9 insect cells
	The UBE2D3 protein is a key player in ubiquitination. It accepts ubiquitin from the E1 complex and covalently attaches it to a variety of proteins, demonstrating multifunctionality. It catalyzes "Lys-11" and "Lys-48" linked polyubiquitination in vitro, regulating protein ubiquitination patterns. UB2D3 Protein, Human (sf9, His, Strep) is the recombinant human-derived UB2D3 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701491

	UB2Q1 Protein, Human (His, StrepⅡ) UBE2Q1; ubiquitin-conjugating enzyme E2 Q1; E2 ubiquitin-conjugating enzyme Q1; Protein NICE-5; ubiquitin carrier protein Q1; ubiquitin-protein ligase Q1	Human	E. coli
	Studies have shown that the UB2Q1 protein plays a key role in cellular processes by catalyzing the covalent attachment of ubiquitin to other proteins. In addition to its ubiquitination function, UB2Q1 may also be involved in female hormonal homeostasis. UB2Q1 Protein, Human (His, Strep) is the recombinant human-derived UB2Q1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

HY-P701496

	UB2E2 Protein, Human (sf9, His, StrepⅡ) UBE2E2; ubiquitin-conjugating enzyme E2 E2; E2 ubiquitin-conjugating enzyme E2; UbcH8; ubiquitin carrier protein E2; ubiquitin-protein ligase E2	Human	Sf9 insect cells
	The UB2E2 protein is a key ubiquitin-proteasome system participant, acting as an E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to proteins. In vitro, UB2E2 exhibits multifunctionality by catalyzing polyubiquitination of “Lys-11,” “Lys-48,” and “Lys-63” linkages, suggesting its involvement in diverse cellular processes. UB2E2 Protein, Human (sf9, His, Strep) is the recombinant human-derived UB2E2 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701839

	ubiquitin Protein, Human (His) UBC; Polyubiquitin-C	Human	E. coli
	Ubiquitin is a multifunctional protein that can form covalently linked isopeptide bonds in various states, including mono- and polyubiquitin chains. ubiquitin Protein, Human (His) is the recombinant human-derived ubiquitin protein, expressed by E. coli , with N-His labeled tag.

HY-P701347

	UbcH6/UBE2E1 Protein, Human (sf9, His, StrepⅡ) UBE2E1; ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UbcH6; ubiquitin carrier protein E1; ubiquitin-protein ligase E1	Human	Sf9 insect cells
	The UbcH6/UBE2E1 protein is an important ubiquitination component that acts as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin in the E1 complex and catalyzing its covalent attachment to proteins. It is versatile and also facilitates covalent attachment of ISG15, playing a role in a variety of ubiquitin-like modifications. UbcH6/UBE2E1 Protein, Human (sf9, His, Strep) is the recombinant human-derived UbcH6/UBE2E1 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701348

	UbcH7/UBE2L3 Protein, Human (sf9, His, StrepⅡ) UBE2L3; ubiquitin-conjugating enzyme E2 L3; E2 ubiquitin-conjugating enzyme L3; L-UBC; UbcH7; ubiquitin carrier protein L3; ubiquitin-conjugating enzyme E2-F1; ubiquitin-protein ligase L3	Human	Sf9 insect cells
	UbcH7/UBE2L3 is a unique ubiquitin-conjugating E2 enzyme that cooperates with HECT-type and RBR family E3 ligases and lacks intrinsic E3-independent reactivity with lysine. It uniquely works with RBR family E3 enzymes such as PRKN, RNF31 and ARIH1, acting like a RING-HECT hybrid. UbcH7/UBE2L3 Protein, Human (sf9, His, Strep) is the recombinant human-derived UbcH7/UBE2L3 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P79449

	UbcH5b/UBE2D2 Protein, Human 3 Publications Verification ubiquitin-conjugating enzyme E2 D2; UBE2D2; (E3-independent) E2 ubiquitin-conjugating enzyme D2 (EC:2.3.2.24); E2 ubiquitin-conjugating enzyme D2; ubiquitin carrier protein D2; ubiquitin-conjugating enzyme E2(17)KB 2; ubiquitin-conjugating enzyme E2-17 kD	Human	E. coli
	The UbcH5b/UBE2D2 protein is an important cellular mediator that accepts ubiquitin from the E1 complex and catalyzes multifunctional “Lys-48”-linked polyubiquitination on target proteins. In addition to its catalytic role, it also concentrates and selectively degrades short-lived proteins and contributes to E6/E6-AP-induced ubiquitination of p53/TP53. UbcH5b/UBE2D2 Protein, Human is the recombinant human-derived UbcH5b/UBE2D2 protein, expressed by E. coli , with tag free.

HY-P701419

	USP46 Protein, Human USP46; ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; ubiquitin thioesterase 46; ubiquitin-specific-processing protease 46	Human	E. coli
	USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human is the recombinant human-derived USP46 protein, expressed by E. coli , with tag free.

HY-P701441

	USP21 Protein, Human USP21; ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinating enzyme 21; ubiquitin thioesterase 21; ubiquitin-specific-processing protease 21	Human	E. coli
	USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation. USP21 Protein, Human is the recombinant human-derived USP21 protein, expressed by E. coli , with tag free.

HY-P702838

	USP1 Protein, Human (His) ubiquitin carboxyl-terminal hydrolase 1; Deubiquitinating enzyme 1 (hUBP); ubiquitin thioesterase 1; ubiquitin-specific-processing protease 1	Human	E. coli
	USP1 Protein, Human (His) is the recombinant human-derived USP1, expressed by E. coli , with N-6*His labeled tag. ,

HY-P71403

	UBE2I Protein, Human (GST) SUMO-Conjugating Enzyme UBC9; SUMO-Protein Ligase; ubiquitin Carrier Protein 9; ubiquitin Carrier Protein I; ubiquitin-Conjugating Enzyme E2 I; ubiquitin-Protein Ligase I; p18; UBE2I; UBC9; UBCE9	Human	E. coli
	The UBE2I protein is a key player in protein sumoylation, accepting the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex. UBE2I cooperates with E3 ligases such as RANBP2, CBX4, and ZNF451 to catalyze the covalent attachment of these SUMO proteins to target proteins, including key substrates FOXL2 and KAT5. UBE2I Protein, Human (GST) is the recombinant human-derived UBE2I protein, expressed by E. coli , with N-GST labeled tag.

HY-P71407

	UBE2R2 Protein, Human (His) ubiquitin-Conjugating Enzyme E2 R2; ubiquitin Carrier Protein R2; ubiquitin-Conjugating Enzyme E2-CDC34B; ubiquitin-Protein Ligase R2; UBE2R2; CDC34B; UBC3B	Human	E. coli
	The UBE2R2 protein is a key element of the ubiquitin-proteasome system and functions as an E2 ubiquitin-conjugating enzyme. It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to a variety of protein substrates. UBE2R2 Protein, Human (His) is the recombinant human-derived UBE2R2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701434

	USP9Y Protein, Human USP9Y; Probable ubiquitin carboxyl-terminal hydrolase FAF-Y; Deubiquitinating enzyme FAF-Y; Fat facets protein-related; Y-linked; ubiquitin thioesterase FAF-Y; ubiquitin-specific protease 9; Y chromosome; ubiquitin-specific-processing protease FAF-Y	Human	E. coli
	The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human is the recombinant human-derived USP9Y protein, expressed by E. coli , with tag free.

HY-P76689

	UCHL3 Protein, Rat (His) ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3; ubiquitin thioesterase L3	Rat	E. coli
	The UCHL3 protein is a deubiquitinating enzyme (DUB) that complexly controls cellular ubiquitin levels by processing ubiquitin precursors and ubiquitinated proteins. As a thiol protease, UCHL3 selectively recognizes and hydrolyzes the peptide bond of ubiquitin or the C-terminal glycine of NEDD8, showing a 10-fold preference for Arg and Lys at the P3 position, and has a special preference for "Lys-48" linked ubiquitin chains. affinity. UCHL3 Protein, Rat (His) is the recombinant rat-derived UCHL3 protein, expressed by E. coli , with N-His labeled tag.

HY-P70998

	UBE2D3 Protein, Human 3 Publications Verification ubiquitin-conjugating enzyme E2 D3; ubiquitin carrier protein D3; ubiquitin-conjugating enzyme E2(17)KB 3; ubiquitin-conjugating enzyme E2-17 kDa 3; ubiquitin-protein ligase D3; UBE2D3 and UBCH5C.	Human	E. coli
	UBE2D3 is able to accept ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfer it to substrates, often promoting its degradation by the proteasome. UBE2D3 Protein, Human is the recombinant human-derived UBE2D3 protein, expressed by E. coli , with tag free.

HY-P71409

	UBE2T Protein, Human (His) ubiquitin-Conjugating Enzyme E2 T; Cell Proliferation-Inducing Gene 50 Protein; ubiquitin Carrier Protein T; ubiquitin-Protein Ligase T; UBE2T	Human	E. coli
	UBE2T protein is an important ubiquitination component. As an E2 ubiquitin-conjugating enzyme, it accepts ubiquitin in the E1 complex and catalyzes its covalent attachment to proteins. This multifaceted enzyme catalyzes monoubiquitination, which is critical during MMC-induced DNA repair. UBE2T Protein, Human (His) is the recombinant human-derived UBE2T protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703671

	USP14 Protein, Human ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; ubiquitin thioesterase 14; ubiquitin-specific-processing protease 14; USP14; TGT	Human	E. coli
	USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. USP14 Protein, Human is the recombinant human-derived USP14 protein, expressed by E. coli, with tag free.

HY-P71398

	UBE2B Protein, Human (HEK293, His) 1 Publications Verification ubiquitin-Conjugating Enzyme E2 B; RAD6 Homolog B; HR6B; hHR6B; ubiquitin Carrier Protein B; ubiquitin-Conjugating Enzyme E2-17 kDa; ubiquitin-Protein Ligase B; UBE2B; RAD6B	Human	HEK293
	The UBE2B protein is a key ubiquitination factor that acts as an E2 ubiquitin-conjugating enzyme, accepting ubiquitin from the E1 complex and catalyzing covalent attachment to proteins. UBE2B works in conjunction with the BRE1 (RNF20 and/or RNF40) E3 enzyme and plays a key role in transcriptional regulation by catalyzing the monoubiquitination of histone H2B at "Lys-120" (H2BK120ub1). UBE2B Protein, Human (HEK293, His) is the recombinant human-derived UBE2B protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P701433

	USP9Y Protein, Human (GST) USP9Y; Probable ubiquitin carboxyl-terminal hydrolase FAF-Y; Deubiquitinating enzyme FAF-Y; Fat facets protein-related; Y-linked; ubiquitin thioesterase FAF-Y; ubiquitin-specific protease 9; Y chromosome; ubiquitin-specific-processing protease FAF-Y	Human	E. coli
	The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human (GST) is the recombinant human-derived USP9Y protein, expressed by E. coli , with N-GST labeled tag.

HY-P71418

	USP14 Protein, Human (His) 1 Publications Verification ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14; ubiquitin Thioesterase 14; ubiquitin-Specific-Processing Protease 14; USP14; TGT	Human	E. coli
	USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. USP14 Protein, Human (His) is the recombinant human-derived USP14 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702063

	USP11 Protein, Human (sf9) 1 Publications Verification USP11; ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; ubiquitin thioesterase 11; ubiquitin-specific-processing protease 11	Human	Sf9 insect cells
	The USP11 protein is a multifunctional protease that selectively removes ubiquitin from target proteins and polyubiquitin chains, thereby hindering their proteasomal degradation. It shows a preference for “Lys-6” and “Lys-63” linked ubiquitin chains and less activity towards other linkages. USP11 Protein, Human (sf9) is the recombinant human-derived USP11 protein, expressed by sf9 insect cells , with tag free.

HY-P701443

	USP22 Protein, Human (sf9) USP22; ubiquitin carboxyl-terminal hydrolase 22; Deubiquitinating enzyme 22; ubiquitin thioesterase 22; ubiquitin-specific-processing protease 22	Human	Sf9 insect cells
	USP22 protein is a histone deubiquitinating enzyme in the SAGA complex that catalyzes the deubiquitination of histones H2A and H2B and acts as a coactivator. Activators such as MYC facilitate its recruitment to gene promoters, which is critical for transcriptional activation. USP22 Protein, Human (sf9) is the recombinant human-derived USP22 protein, expressed by sf9 insect cells , with tag free.

HY-P701446

	USP28 Protein, Human (sf9) USP28; ubiquitin carboxyl-terminal hydrolase 28; Deubiquitinating enzyme 28; ubiquitin thioesterase 28; ubiquitin-specific-processing protease 28	Human	Sf9 insect cells
	The USP28 protein serves as a deubiquitinase and plays a key role in the DNA damage response checkpoint and the stability of the MYC proto-oncogene. It selectively deubiquitinates DNA damage pathway proteins such as CLSPN, thereby regulating apoptosis. USP28 Protein, Human (sf9) is the recombinant human-derived USP28 protein, expressed by sf9 insect cells , with tag free.

HY-P701418

	USP46 Protein, Human (His, GST) USP46; ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; ubiquitin thioesterase 46; ubiquitin-specific-processing protease 46	Human	E. coli
	USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human (His, GST) is the recombinant human-derived USP46 protein, expressed by E. coli , with N-6*His, N-GST labeled tag.

HY-P701426

	USP51 Protein, Human (sf9) USP51; ubiquitin carboxyl-terminal hydrolase 51; Deubiquitinating enzyme 51; ubiquitin thioesterase 51; ubiquitin-specific-processing protease 51	Human	Sf9 insect cells
	The USP51 protein uniquely regulates the DNA damage response by deubiquitinating the "Lys-14" (H2AK13Ub) and "Lys-16" (H2AK15Ub) residues of histone H2A at double-strand breaks. After DNA damage, USP51 is recruited to chromatin and regulates TP53BP1 and BRCA1 assembly/disassembly, which is critical for DNA repair. USP51 Protein, Human (sf9) is the recombinant human-derived USP51 protein, expressed by sf9 insect cells , with tag free.

HY-P701448

	USP29 Protein, Human (sf9) USP29; ubiquitin carboxyl-terminal hydrolase 29; Deubiquitinating enzyme 29; ubiquitin thioesterase 29; ubiquitin-specific-processing protease 29	Human	Sf9 insect cells
	USP29 protein, as a deubiquitinating enzyme, plays a crucial role in innate antiviral immunity by mediating "Lys-48" deubiquitination of CGAS. This effect stabilizes CGAS, an important sensor of the cellular response to viral infection, emphasizing the importance of USP29 in regulating CGAS activity. USP29 Protein, Human (sf9) is the recombinant human-derived USP29 protein, expressed by sf9 insect cells , with tag free.

HY-P701454

	USP37 Protein, Human (sf9) USP37; ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinating enzyme 37; ubiquitin thioesterase 37; ubiquitin-specific-processing protease 37	Human	Sf9 insect cells
	The USP37 protein is a multifunctional deubiquitinase that regulates critical cellular processes. During the G1/S transition, it deubiquitinates cyclin A, promotes S phase entry, and enhances activity through Ser-628 phosphorylation. USP37 Protein, Human (sf9) is the recombinant human-derived USP37 protein, expressed by sf9 insect cells , with tag free.

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Host:	Mouse (18) Rabbit (101)
Reactivity:	Human (118) Bovine (1) Rat (77) Mouse (78) Monkey (2) Species independent (1) Dog (2) Pig (3)
Application:	WB FC ICC/IF (1) IHC-P (57) ICC/IF (69) IF-Tissue (7) IP (41) DotBlot (1) IHC-F (8) WB (114) ChIP (1) FC (33) ELISA (13)
Isotype:	IgG (97) IgG1 (7) IgG/Kappa (3) IgG2b (1) IgG,IgG/Kappa (1)
Conjugation:	Non-conjugated (119)
Clonality:	Polyclonal (1) polyclonal (1) Monoclonal (93) Recombinant (67)
Modification:	Phosphorylated (2) Unmodified (93)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80925

	Ubiquitin Antibody 3 Publications Verification FLJ25987; MGC8385; ubiquitin B; ubiquitin; UBCEP1; UBCEP2; RPS27A	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Ubiquitin Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Ubiquitin.

HY-P80363

	Ubiquitin Antibody (YA022)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Ubiquitin Antibody (YA022) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ubiquitin.

HY-P85694

	Ubiquitin Antibody (YA5386)	IHC-P, WB	Species independent
	Ubiquitin Antibody (YA5386) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ubiquitin.

HY-P85761

	Ubiquitin Antibody (YA5453)	WB, ICC/IF, IHC-P	Human, Rat, Mouse, Pig
	Ubiquitin Antibody (YA5453) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ubiquitin.

HY-P87374

	USP2 Antibody (YA7057) 41 kDa ubiquitin specific protease antibody; 41 kDa ubiquitin-specific protease antibody; Deubiquitinating enzyme 2 antibody; ubiquitin carboxyl terminal hydrolase 2 antibody; ubiquitin carboxyl-terminal hydrolase 2 antibody; ubiquitin specific peptidase 2 antibody; ubiquitin specific processing protease 2 antibody; ubiquitin specific protease 12 antibody; ubiquitin specific protease 9 antibody; ubiquitin specific protease, 41kD antibody	WB	Human
	USP2 Antibody (YA7057) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to USP2.

HY-P80364

	Ubiquitin D Antibody (YA021) 1 Publications Verification	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Ubiquitin D Antibody (YA021) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ubiquitin D.

HY-P87559

	Ubiquitin D Antibody (YA7243)	WB, IHC-P, IHC-F, IF-Tissue, ICC/IF	Human
	Ubiquitin D Antibody (YA7243) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ubiquitin D.

HY-P87135

	USP5 Antibody (YA6828) Deubiquitinating enzyme 5 antibody; Isopeptidase T antibody; ISOT 1 antibody; ISOT antibody; ubiquitin carboxyl-terminal hydrolase 5 antibody; ubiquitin isopeptidase T antibody; ubiquitin specific peptidase 5 (isopeptidase T) antibody; ubiquitin specific peptidase 5 antibody; ubiquitin specific processing protease 5 antibody; ubiquitin specific protease 5 (isopeptidase T) antibody; Deubiquitinating enzyme 5 antibody; Isopeptidase T antibody; ISOT 1 antibody; ISOT antibody; ubiquitin carboxyl-terminal hydrolase 5 antibody; ubiquitin isopeptidase T antibody; ubiquitin specific peptidase 5 (isopeptidase T) antibody; ubiquitin specific peptidase 5 antibody; ubiquitin specific processing protease 5 antibody; ubiquitin specific protease 5 (isopeptidase T) antibody; ubiquitin specific protease 5 (ubiquitin isopeptidase T) antibody; ubiquitin thioesterase 5 antibody; ubiquitin thiolesterase 5 antibody; ubiquitin-specific-processing protease 5 antibody; UBP5_HUMAN antibody; Usp5 antibody;	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	USP5 Antibody (YA6828) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP5.

HY-P87132

	USP24 Antibody (YA6825) "Deubiquitinating enzyme 24 antibody; KIAA1057 antibody; ubiquitin carboxyl terminal hydrolase 24 antibody; ubiquitin carboxyl-terminal hydrolase 24 antibody; ubiquitin specific peptidase 24 antibody; ubiquitin specific processing protease 24 antibody; ubiquitin specific protease 24 antibody; ubiquitin thioesterase 24 antibody; ubiquitin thiolesterase 24 antibody; ubiquitin-specific-processing protease 24 antibody; "Deubiquitinating enzyme 24 antibody; KIAA1057 antibody; ubiquitin carboxyl terminal hydrolase 24 antibody; ubiquitin carboxyl-terminal hydrolase 24 antibody; ubiquitin specific peptidase 24 antibody; ubiquitin specific processing protease 24 antibody; ubiquitin specific protease 24 antibody; ubiquitin thioesterase 24 antibody; ubiquitin thiolesterase 24 antibody; ubiquitin-specific-processing protease 24 antibody; UBP24_HUMAN antibody; Usp24 antibody; "	WB, ICC/IF, IHC-P	Human, Mouse
	USP24 Antibody (YA6825) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP24.

HY-P86479

	Ubiquitin K48 Antibody (YA6171) UBB; Polyubiquitin-B; UBC; Polyubiquitin-C; RPS27A; UBA80; UBCEP1; ubiquitin-40S ribosomal protein S27a; ubiquitin carboxyl extension protein 80; UBA52; UBCEP2; ubiquitin-60S ribosomal protein L40; CEP52; ubiquitin A-52 residue ribosomal pr; ubiquitin K48;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Ubiquitin K48 Antibody (YA6171) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ubiquitin K48.

HY-P86680

	PGP9.5 Antibody (YA6372) Gracile axonal dystrophy; Neuron cytoplasmic protein 9.5; Park 5; Park5; Parkinson Disease 5; PGP 9.5; PGP9.5; PGP95; Protein gene product 9.5; ubiquitin C terminal esterase L1; ubiquitin C terminal hydrolase(neuron specific); ubiquitin C terminal hydrolase; ubiquitin carboxyl terminal esterase L1; ubiquitin carboxyl terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; ubiquitin thiolesterase; ubiquitin thiolesterase L1; UCH L1; UCH-L1; UCHL1; UCHL1_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	PGP9.5 Antibody (YA6372) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PGP9.5.

HY-P85431

	HAUSP/USP7 Antibody (YA5123) USP7; HAUSP; ubiquitin carboxyl-terminal hydrolase 7; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; ubiquitin thioesterase 7; ubiquitin-specific-processing protease 7	WB, ICC/IF	Human, Mouse, Rat, Dog, Pig
	HAUSP/USP7 Antibody (YA5123) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HAUSP/USP7.

HY-P85512

	HAUSP/USP7 Antibody (YA5204) Deubiquitinating enzyme 7; HAUSP; herpes virus associated; Herpes virus associated ubiquitin specific protease; Herpesvirus-associated ubiquitin-specific protease; TEF 1; tef-1; TEF1; ubiquitin carboxyl terminal hydrolase 7; ubiquitin carboxyl-terminal hydrolase 7; ubiquitin specific peptidase 7; herpes virus associated; ubiquitin specific peptidase 7; ubiquitin specific peptidase 7 herpes virus associated; ubiquitin specific processing protease 7; ubiquitin specific protease 7; herpes virus associated; ubiquitin Specific Protease 7; ubiquitin specific protease 7 herpes virus associated; ubiquitin thioesterase 7; ubiquitin thiolesterase 7; ubiquitin-specific-processing protease 7; UBP 7; UBP-7; UBP7; UBP7_HUMAN; USP 7; usp-7; USP7; VMW110-ASSOCIATED PROTEIN,135-KD.	WB	Human
	HAUSP/USP7 Antibody (YA5204) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HAUSP/USP7.

HY-P83041

	CDC34 Antibody (YA2786) CDC34; UBCH3; UBE2R1; ubiquitin-conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; ubiquitin-protein ligase R1	WB, IP	Human, Mouse, Rat
	CDC34 Antibody (YA2786) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDC34.

HY-P83041A

	CDC34 Antibody (YA2786)(PBS only) CDC34; UBCH3; UBE2R1; ubiquitin-conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; ubiquitin-protein ligase R1	WB, IP	Human, Mouse, Rat
	CDC34 Antibody (YA2786) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDC34.

HY-P80926

	HAUSP/USP7 Antibody (YA657) Deubiquitinating enzyme 7; HAUSP; herpes virus associated; Herpes virus associated ubiquitin specific protease; Herpesvirus-associated ubiquitin-specific protease; TEF 1; tef-1; TEF1; ubiquitin carboxyl terminal hydrolase 7; ubiquitin carboxyl-terminal hy	WB	Human
	HAUSP/USP7 Antibody (YA657) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HAUSP/USP7.

HY-P83556

	SUMO Conjugating Enzyme UBC9 Antibody (YA3301) UBE2I; UBC9; UBCE9; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-conjugating enzyme E2 I; ubiquitin-protein ligase I; p18	WB, IHC-P, IHC-F, ICC/IF, IP, FC	Human, Mouse, Rat
	SUMO Conjugating Enzyme UBC9 Antibody (YA3301) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUMO Conjugating Enzyme UBC9.

HY-P85404

	SUMO Conjugating Enzyme UBC9 Antibody (YA5096) UBE2I; UBC9; UBCE9; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-conjugating enzyme E2 I; ubiquitin-protein ligase I; p18	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, IP, FC	Human, Mouse
	SUMO Conjugating Enzyme UBC9 Antibody (YA5096) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to SUMO Conjugating Enzyme UBC9.

HY-P87128

	UBE2T Antibody (YA6821) Cell proliferation inducing gene 50 protein antibody; Cell proliferation-inducing gene 50 protein antibody; HSPC150 antibody; HSPC150 protein similar to ubiquitin conjugating enzyme antibody; PIG50 antibody; Ube2t antibody; UBE2T_HUMAN antibody; ubiquitin carrier protein T antibody; ubiquitin conjugating enzyme antibody; ubiquitin conjugating enzyme E2 T antibody; Cell proliferation inducing gene 50 protein antibody; Cell proliferation-inducing gene 50 protein antibody; HSPC150 antibody; HSPC150 protein similar to ubiquitin conjugating enzyme antibody; PIG50 antibody; Ube2t antibody; UBE2T_HUMAN antibody; ubiquitin carrier protein T antibody; ubiquitin conjugating enzyme antibody; ubiquitin conjugating enzyme E2 T antibody; ubiquitin conjugating enzyme E2T antibody; ubiquitin protein ligase T antibody; ubiquitin-conjugating enzyme E2 T antibody; ubiquitin-protein ligase T antibody;	WB, ICC/IF	Human, Mouse, Rat
	UBE2T Antibody (YA6821) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to UBE2T.

HY-P80926A

	HAUSP/USP7 Antibody (YA657)(PBS only) Deubiquitinating enzyme 7; HAUSP; herpes virus associated; Herpes virus associated ubiquitin specific protease; Herpesvirus-associated ubiquitin-specific protease; TEF 1; tef-1; TEF1; ubiquitin carboxyl terminal hydrolase 7; ubiquitin carboxyl-terminal hy	WB	Human
	HAUSP/USP7 Antibody (YA657) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HAUSP/USP7.

HY-P83556A

	SUMO Conjugating Enzyme UBC9 Antibody (YA3301)(PBS only) UBE2I; UBC9; UBCE9; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-conjugating enzyme E2 I; ubiquitin-protein ligase I; p18	WB, IHC-P, IHC-F, ICC/IF, IP, FC	Human, Mouse, Rat
	SUMO Conjugating Enzyme UBC9 Antibody (YA3301) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUMO Conjugating Enzyme UBC9.

HY-P81591

	USP28 Antibody (YA1336) KIAA1515; ubiquitin carboxyl terminal hydrolase 28; ubiquitin thioesterase 28; UBP28	WB, ICC/IF, FC	Human
	USP28 Antibody (YA1336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP28.

HY-P83066

	UCHL3 Antibody (YA2811) UCH-L3; ubiquitin thiolesterase L3; ubiquitin carboxyl-terminal hydrolase isozyme L3; UCHL3	WB	Human, Mouse, Rat
	UCHL3 Antibody (YA2811) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to UCHL3.

HY-P85926

	PGP9.5 Antibody (YA5618) Epididymis luminal protein 117; Epididymis secretory protein Li 53; HEL 117; HEL S 53; NDGOA; Neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; Park 5; PARK5; PGP 9.5; PGP9.5; PGP95; Protein gene product 9.5; ubiquitin C terminal esterase L1; ubiquitin C terminal hydrolase; ubiquitin C terminal hydrolase L1; ubiquitin carboxyl terminal esterase L1; ubiquitin carboxyl terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; ubiquitin thiolesterase; ubiquitin thiolesterase L1; UCH-L1; UCHL1; UCHL1_HUMAN	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	PGP9.5 Antibody (YA5618) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGP9.5.

HY-P85405

	UBE1L Antibody (YA5097) UBA7; UBE1L; UBE2; ubiquitin-like modifier-activating enzyme 7; ubiquitin-activating enzyme 7; D8; ubiquitin-activating enzyme E1 homolog	WB, IHC-P, IHC-F, FC, IF-Tissue	Human, Mouse, Rat
	UBE1L Antibody (YA5097) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to UBE1L.

HY-P82072

	*E1 Ubiquitin* Activating Enzyme 1/UBA1 Antibody (YA1817)** UBA1; A1S9T; UBE1; ubiquitin-like modifier-activating enzyme 1; Protein A1S9; ubiquitin-activating enzyme E1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	E1 Ubiquitin Activating Enzyme 1/UBA1 Antibody (YA1817) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to E1 Ubiquitin Activating Enzyme 1/UBA1.

HY-P84039

	Ubiquitin Antibody (YA3736) UBC; UBA52; RPS27A	WB, FC, ELISA	Human
	Ubiquitin Antibody (YA3736) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ubiquitin.

HY-P81738

	OTUB1 Antibody (YA1483) OTUB1; OTB1; OTU1; HSPC263; ubiquitin thioesterase OTUB1; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; hOTU1; ubiquitin-specific-processing protease OTUB1	WB, IP	Human, Mouse, Rat
	OTUB1 Antibody (YA1483) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to OTUB1.

HY-P87316

	Sumo 2+3 Antibody (YA6999) HSMT3 antibody; MGC117191 antibody; OTTHUMP00000115275 antibody; OTTHUMP00000115276 antibody; OTTHUMP00000115277 antibody; Sentrin 2 antibody; Small ubiquitin like modifier 2 antibody; Small ubiquitin related modifier 2 antibody; small ubiquitin-like modifier 3 antibody; small ubiquitin-related modifier 3 antibody	IHC-P, IHC-F, IF-Tissue, FC, ICC/IF	Human, Mouse, Rat
	Sumo 2+3 Antibody (YA6999) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sumo 2+3.

HY-P80365

	*E1 Ubiquitin* Activating Enzyme 1/UBA1 Antibody (YA020)**	WB, ICC/IF, IHC-P, FC	Human, Mouse
	E1 Ubiquitin Activating Enzyme 1/UBA1 Antibody (YA020) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to E1 Ubiquitin Activating Enzyme 1/UBA1.

HY-P81738A

	OTUB1 Antibody (YA1483)(PBS only) OTUB1; OTB1; OTU1; HSPC263; ubiquitin thioesterase OTUB1; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; hOTU1; ubiquitin-specific-processing protease OTUB1	WB, IP	Human, Mouse, Rat
	OTUB1 Antibody (YA1483) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to OTUB1.

HY-P83561

	Ubiquitin Protein Ligase E3A Antibody (YA3306) ubiquitin-protein ligase E3A; UBE3A; E6AP; EPVE6AP; HPVE6A	WB, ICC/IF, FC, IP	Human, Mouse, Rat
	Ubiquitin Protein Ligase E3A Antibody (YA3306) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ubiquitin Protein Ligase E3A.

HY-P86900

	HIP2/LIG Antibody (YA6593) E2 25K antibody; E2(25K) antibody; HIP-2 antibody; Huntingtin interacting protein 2 antibody; Huntingtin-interacting protein 2 antibody; HYPG antibody; LIG antibody; UBC1 antibody; UBE2K antibody; UBE2K_HUMAN antibody; E2 25K antibody; E2(25K) antibody; HIP-2 antibody; Huntingtin interacting protein 2 antibody; Huntingtin-interacting protein 2 antibody; HYPG antibody; LIG antibody; UBC1 antibody; UBE2K antibody; UBE2K_HUMAN antibody; ubiquitin carrier protein antibody; ubiquitin conjugating enzyme E2 25 kDa antibody; ubiquitin conjugating enzyme E2K antibody; ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast) antibody; ubiquitin protein ligase antibody; ubiquitin-conjugating enzyme E2 K antibody; ubiquitin-conjugating enzyme E2(25K) antibody; ubiquitin-conjugating enzyme E2-25 kDa antibody; ubiquitin-conjugating enzyme E2-25K antibody; ubiquitin-protein ligase antibody;	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat, Monkey
	HIP2/LIG Antibody (YA6593) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIP2/LIG.

HY-P80905

	SUMO1 Antibody (YA047) SUMO1; SMT3C; SMT3H3; UBL1; OK/SW-cl.43; Small ubiquitin-related modifier 1; SUMO-1; GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; ubiquitin-homology domain protein PIC1; ubiquitin-like protein SMT3C; Smt3C; ubiquitin-like protein	WB, IHC-P	Human, Mouse, Rat
	SUMO1 Antibody (YA047) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUMO1.

HY-P86396

	SUMO1 Antibody (YA6088) SUMO1; SMT3C; SMT3H3; UBL1; OK/SW-cl.43; Small ubiquitin-related modifier 1; SUMO-1; GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; ubiquitin-homology domain protein PIC1; ubiquitin-like protein SMT3C; Smt3C; ubiquitin-like protein	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	SUMO1 Antibody (YA6088) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUMO1.

HY-P84039A

	Ubiquitin Antibody (YA3736)(PBS only) UBC; UBA52; RPS27A	WB, FC, ELISA	Human
	Ubiquitin Antibody (YA3736) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ubiquitin.

HY-P83583

	PMS2 Antibody (YA3328) TGT; tRNA guanine transglycosylase 60 kD subunit; ubiquitin carboxyl terminal hydrolase 14; ubiquitin specific peptidase 14; USP14	WB, ICC/IF, FC	Human, Mouse, Rat
	PMS2 Antibody (YA3328) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PMS2.

HY-P83561A

	Ubiquitin Protein Ligase E3A Antibody (YA3306)(PBS only) ubiquitin-protein ligase E3A; UBE3A; E6AP; EPVE6AP; HPVE6A	WB, ICC/IF, FC, IP	Human, Mouse, Rat
	Ubiquitin Protein Ligase E3A Antibody (YA3306) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ubiquitin Protein Ligase E3A.

HY-P86161

	UBA52 Antibody (YA5853) UBA52; UBCEP2; ubiquitin-60S ribosomal protein L40; CEP52; ubiquitin A-52 residue ribosomal protein fusion product 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	UBA52 Antibody (YA5853) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to UBA52.

HY-P80905A

	SUMO1 Antibody (YA047)(PBS only) SUMO1; SMT3C; SMT3H3; UBL1; OK/SW-cl.43; Small ubiquitin-related modifier 1; SUMO-1; GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; ubiquitin-homology domain protein PIC1; ubiquitin-like protein SMT3C; Smt3C; ubiquitin-like protein	WB, IHC-P	Human, Mouse, Rat
	SUMO1 Antibody (YA047) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUMO1.

HY-P87190

	SIAH1 Antibody (YA6878) E3 ubiquitin-protein ligase SIAH1 antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	SIAH1 Antibody (YA6878) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SIAH1.

HY-P80351

	SUMO1 Antibody (YA046) 2 Publications Verification DAP1 antibody; GAP modifying protein 1 antibody; GMP 1 antibody; OFC10 antibody; PIC 1 antibody; PIC1 antibody; SENP2 antibody; Sentrin 1 antibody; Sentrin antibody; Small ubiquitin related modifier 1 antibody; Small ubiquitin-like modifier 1 antibody; Small ubiquitin-related modifier 1 antibody; SMT3 antibody; SMT3 homolog 3 antibody; SMT3 suppressor of mif two 3 homolog 1 antibody; SMT3, yeast, homolog 3 antibody; Smt3C antibody; SMT3H3 antibody; SUMO-1 antibody; SUMO1 antibody; SUMO1_HUMAN antibody; ubiquitin homology domain protein PIC1 antibody; ubiquitin Like 1 antibody; ubiquitin like protein SMT3C antibody; ubiquitin like protein UBL1 antibody; ubiquitin-homology domain protein PIC1 antibody; ubiquitin-like protein SMT3C antibody; ubiquitin-like protein UBL1 antibody; UBL 1 antibody; UBL1 antibody	WB, ICC/IF, IHC-P, IP, FC, ChIP	Human, Mouse, Rat
	SUMO1 Antibody (YA046) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUMO1.

HY-P87078

	SMURF1 Antibody (YA6771) E3 ubiquitin-protein ligase SMURF1 antibody; hSMURF1 antibody; KIAA1625 antibody; Smad specific E3 ubiquitin ligase 1 antibody; SMAD specific E3 ubiquitin protein ligase 1 antibody; Smad ubiquitination regulatory factor 1 antibody; SMAD-specific E3 ubiquitin-protein ligase 1 antibody; SMUF1_HUMAN antibody; SMURF 1 antibody; smurf1 antibody;	WB	Human
	SMURF1 Antibody (YA6771) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SMURF1.

HY-P81832

	UFM1 Antibody (YA1577) 1 Publications Verification ubiquitin-fold modifier 1; C13orf20	WB, IHC-P, IP	Human, Mouse
	UFM1 Antibody (YA1577) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to UFM1.

HY-P86509

	ATG7 Antibody (YA6201) ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; ubiquitin-activating enzyme E1-like protein;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ATG7 Antibody (YA6201) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG7.

HY-P80559

	ATG7 Antibody (YA598) hAGP7; ubiquitin-activating enzyme E1-like protein; APG7L	WB	Human, Mouse, Rat
	ATG7 Antibody (YA598) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATG7.

HY-P81589

	USP22 Antibody (YA1334) ubiquitin carboxyl terminal hydrolase 22; Usp22; USP3L	WB, ICC/IF, IP, FC	Human
	USP22 Antibody (YA1334) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP22.

HY-P81832A

	UFM1 Antibody (YA1577)(PBS only) ubiquitin-fold modifier 1; C13orf20	WB, IHC-P, IP	Human, Mouse
	UFM1 Antibody (YA1577) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to UFM1.

HY-P85483

	UHRF1(N-term) Antibody (YA5175) Ac2-121; AL022808; E3 ubiquitin-protein ligase UHRF1; FLJ21925; Hnp95 Huhrf1; HuNp95; ICBP90; Inverted CCAAT box binding protein of 90 kDa; Inverted CCAAT box binding protein, 90-Kd; Inverted CCAAT box-binding protein of 90 kDa; Liver regeneration-related protein LRRG126; MGC138707; NP95; Nuclear phosphoprotein, 95-KD; Nuclear protein 95; Nuclear zinc finger protein Np95; RING finger protein 106; RNF106; Transcription factor ICBP90; ubiquitin like containing PHD and RING finger domains protein 1; ubiquitin like PHD and RING finger domain containing protein 1; ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like protein containing PHD and RING finger domains 1; ubiquitin-like with PHD and ring finger domains 1; ubiquitin-like, containing PHD and RING finger domains, 1; ubiquitin-like-containing PHD and RING finger domains protein 1; UHRF1; UHRF1_HUMAN.	WB	Human, Mouse
	UHRF1(N-term) Antibody (YA5175) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to UHRF1(N-term).

HY-P82989

	Ubiquitin Conjugating Enzyme E2 C Antibody (YA2734) UBCH 10; UbcH10; Ube2c	WB	Human
	Ubiquitin Conjugating Enzyme E2 C Antibody (YA2734) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ubiquitin Conjugating Enzyme E2 C.

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Cat. No.	Product Name		Classification

HY-129602

SD-36 5+ Cited Publications		PROTAC Synthesis
SD-36 is a potent and efficacious STAT3 PROTAC degrader (K_d=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC₅₀=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase . SD-36 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-114670

Propargyl-PEG4-amine		PROTAC Synthesis Alkynes
Propargyl-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-126885

DBCO-PEG5-NHS ester 1 Publications Verification		DBCO ADC Synthesis PROTAC Synthesis
DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-W051634

Propargyl-PEG2-amine		ADC Synthesis Alkynes PROTAC Synthesis
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-69220

7-Octynoic acid		PROTAC Synthesis Alkynes
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-114402

ARD-69		PROTAC Synthesis
ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor, which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells. ARD-69 inhibits AR-regulated gene expression, binds to the AR ligand binding domain at one end and binds to VHL at the other end, prompting AR to be recruited to the E3 ubiquitin ligase complex, triggering proteasome degradation, thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA, TMPRSS2). ARD-69 can be used to study of castration-resistant prostate cancer (mCRPC) . ARD-69 is composed of a target protein ligand (pink part) AR antagonist 14 (HY-172624), a PROTAC linker (black part) tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and a VHL-type E3 ubiquitinase ligand (blue part) VH 101, acid (HY-47070); among them, the VHL ligand and the linker can form a conjugate VH 101-amide-piperidine-Pip-alkyne (HY-172625).

HY-153627

GK13S		Alkynes
GK13S is a deubiquitinase UCHL1 ligand and inhibitor. GK13S inhibits recombinant and cellular UCHL1. GK13S reduces levels of monoubiquitin in human glioblastoma cells . GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141178

TCO-PEG3-amine		TCO
TCO-PEG3-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-130147

Propargyl-PEG5-OH		PROTAC Synthesis Alkynes
Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133229

Propargyl-PEG4-alcohol		PROTAC Synthesis Alkynes
Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG4-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-108374

4-Azidobutylamine		PROTAC Synthesis Azide
4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152261

MS6105		PROTAC Synthesis
MS6105 is an LDH protein hydrolysis-targeted chimera (PROTAC) that effectively degrades LDHA and LDHB in a time- and ubiquitin-proteasome system-dependent manner and has anticancer activity . MS6105 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101460

Tz-Thalidomide		Tetrazine
Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a CLIP-TAC (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research .

HY-126976

Propargyl-PEG5-amine		Alkynes PROTAC Synthesis ADC Synthesis
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG5-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141183

TCO-PEG4-biotin		TCO
TCO-PEG4-biotin is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141177

TCO-PEG2-amine		TCO
TCO-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141169

TCO-PEG8-NHS ester		TCO
TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-130373

Propargyl-PEG9-amine		PROTAC Synthesis Alkynes
Propargyl-PEG9-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG9-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-118808

Propargyl-PEG2-NHBoc		Alkynes ADC Synthesis PROTAC Synthesis
Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159147

SIAIS039		Azide
SIAIS039 is an orally active c-ros oncogene 1 (ROS1)-specific PROTAC with DC₅₀s of 154.46 nM, 126.47 nM, 143.69 nM for HCC78 cells, Ba/F3 expressing the CD74-ROS1 fusion and Ba/F3 expressing the SDC4-ROS1 fusion, respectively. SIAIS039 suppresses cell proliferation, induces cell cycle arrest and apoptosis, and inhibits clonogenicity against ROS1-positive cells. SIAIS039 demonstrates anti-tumour effects against ROS1-driven tumor growth vivo. SIAIS039 is composed of the ALK inhibitor Brigatinib (HY-12857), a linker EM-12 (HY-138793), and a VHL ligand E3 ubiquitin ligase 1-Butyne (Red: Brigatinib; Blue: VHL ligand; Black: linker) .

HY-141180

TCO-PEG6-amine		TCO
TCO-PEG6-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-130384

Propargyl-PEG6-Boc		PROTAC Synthesis Alkynes
Propargyl-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG6-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141187

TCO-PEG3-TCO		TCO
TCO-PEG3-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-140015

TCO-PEG3-acid		PROTAC Synthesis TCO
TCO-PEG3-acid is a click chemistry reagent that contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups .

HY-141179

TCO-PEG4-amine		TCO
TCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-W458035

Desamino lenalidomide-alkynes		Alkynes
Desamino lenalidomide-alkynes is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Desamino lenalidomide-alkynes can be linked to a target protein ligand via a linker to form a PROTAC.

HY-130387

Propargyl-PEG4-Tos		PROTAC Synthesis Alkynes ADC Synthesis
Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-140310

TCO-PEG4-DBCO		DBCO PROTAC Synthesis ADC Synthesis TCO
TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-130382

Propargyl-PEG6-alcohol		Alkynes PROTAC Synthesis
Propargyl-PEG6-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG6-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130563

Propargyl-PEG3-CH2COOH		PROTAC Synthesis Alkynes
Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG3-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-115414

Bis-propargyl-PEG8		Alkynes PROTAC Synthesis
Bis-propargyl-PEG8 (compound 16e) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-117045

Propargyl-PEG12-OH		PROTAC Synthesis Alkynes
Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG12-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141166

TCO-PEG3-NHS ester		TCO
TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-133230

Propargyl-PEG10-amine		PROTAC Synthesis Alkynes
Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG10-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141189

TCO-PEG8-TCO		TCO
TCO-PEG8-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-113921

m-PEG4-propargyl		Alkynes PROTAC Synthesis
m-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141168

TCO-PEG6-NHS ester		TCO
TCO-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-161131

Lenalidomide 4'-alkyl-C3-azide		Azide
Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups .

HY-130146

Propargyl-PEG3-phosphonic acid diethyl ester		Alkynes PROTAC Synthesis
Propargyl-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG3-phosphonic acid diethyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130390

Propargyl-PEG4-O-C1-NHS ester		Alkynes PROTAC Synthesis
Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-O-C1-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130374

Propargyl-PEG8-OH		PROTAC Synthesis Alkynes
Propargyl-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG8-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130389

Propargyl-PEG4-O-C1-Boc		Alkynes PROTAC Synthesis
Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG4-O-C1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130375

Propargyl-PEG8-Boc		PROTAC Synthesis Alkynes
Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG8-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130378

Propargyl-PEG7-alcohol		Alkynes PROTAC Synthesis
Propargyl-PEG7-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG7-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130584

Propargyl-PEG2-MS		PROTAC Synthesis Alkynes
Propargyl-PEG2-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-MS is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130380

Propargyl-PEG7-Boc		PROTAC Synthesis Alkynes
Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG7-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141181

TCO-PEG8-amine		TCO
TCO-PEG8-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-133049

Propargyl-PEG3-phosphonic acid		Alkynes PROTAC Synthesis
Propargyl-PEG3-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG3-phosphonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141159

TCO-PEG4-acid		TCO
TCO-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141160

TCO-PEG6-acid		TCO
TCO-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

Cat. No.	Product Name		Classification

HY-132580

Tofersen 2 Publications Verification BIIB067; ISIS-SOD1Rx; ISIS 333611		Antisense Oligonucleotides
Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .

HY-132580A

Tofersen sodium 2 Publications Verification BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium		Antisense Oligonucleotides
Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .

HY-148130

Rugonersen RG6091; RO7248824		Antisense Oligonucleotides
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-148130A

Rugonersen sodium RG6091 sodium; RO7248824 sodium		Antisense Oligonucleotides
Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-177651

Obudanersen ION-582		Antisense Oligonucleotides
Obudanersen is an antisense oligonucleotide targeted to ubiquitin protein ligase E3A-antisense transcript (UBE3A-ATS). It is used for the study of Angelman syndrome.

HY-177651A

Obudanersen sodium ION-582 sodium		Antisense Oligonucleotides
Obudanersen sodium is an antisense oligonucleotide targeted to ubiquitin protein ligase E3A-antisense transcript (UBE3A-ATS). It is used for the study of Angelman syndrome.

HY-132580S

Tofersen-d27 BIIB067-d₂₇; ISIS-SOD1Rx-d₂₇; ISIS 333611-d₂₇		Antisense Oligonucleotides
Tofersen-d₂₇ (BIIB067-d₂₇) is the deuterium labeled Tofersen (HY-132580). Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC₅₀ of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis.

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