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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
vitronectin
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "vitronectin" in MCE Product Catalog:
74
Target:
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cilengitide (EMD 121974) is a BBB-permeable integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM (α5β1), respectively. Cilengitide inhibits the binding of ανβ3 and ανβ5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers .
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Research Areas:
2
1
1 Cited Publications
Cat. No.: HY-P1741
CAS No.: 137235-80-4
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P1741A
Target:
Research Areas:
1
Cat. No.: HY-P99296
CAS No.: 725735-28-4
Synonyms: CNTO 95; Anti-Human CD51 Recombinant Antibody
Cat. No.: HY-P990552A
Cat. No.: HY-117133
CAS No.: 1621332-91-9
Synonyms: SF0166
Target:
Research Areas:
Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model .
Cat. No.: HY-P1187
CAS No.: 848644-86-0
Cat. No.: HY-P2452
CAS No.: 1217344-74-5
Target:
Research Areas:
CDE-096 is a potent inhibitor of PAI-1. CDE-096 prevents PAI-1 from inactivating tPA and uPA with similar potency (IC50=30 and 25 nM, respectively) and is active against glycosylated PAI-1, as well as PAI-1 derived from several species (IC50=19, 22 and 18 nM for murine, rat, and Porcine PAI-1, respectively) .
Category:
Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics
Target:
Cat. No.: HY-125053A
Purity: 99.58%
Target:
Research Areas:
Cat. No.: HY-16141R
CAS No.: 188968-51-6
Synonyms: EMD 121974 (Standard)
Research Areas:
Cilengitide (Standard) is the analytical standard of Cilengitide. This product is intended for research and analytical applications. Cilengitide (EMD 121974) is a BBB-permeable integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM (α5β1), respectively. Cilengitide inhibits the binding of ανβ3 and ανβ5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers .
Cat. No.: HY-125053
CAS No.: 710312-77-9
Target:
Research Areas:
Cat. No.: HY-P70485G
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: vitronectin; VN; S-Protein; Serum-Spreading Factor; V75; VTN
Cat. No.: HY-P704067
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: vitronectin; truncated; VN; S-Protein; Serum-Spreading Factor; V75; VTN
Cat. No.: HY-P704969
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: vitronectin; VN; S-Protein; Serum-Spreading Factor; V75; VTN
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
