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worm

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59

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0176
    Dihydroartemisinin
    Maximum Cited Publications
    45 Publications Verification

    Dihydroqinghaosu; β-Dihydroartemisinin; Artenimol

    		 Parasite NF-κB Autophagy Reactive Oxygen Species (ROS) Drug Metabolite Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection .
    Dihydroartemisinin
  • HY-B1761
    Santonin

    Alpha-Santonin

    		 Parasite Infection
    Santonin is an active principle of the plant Artemisia cina, which is formely used to treat worms .
    Santonin
  • HY-12640
    Pyrantel pamoate
    4 Publications Verification

    Pyrantel embonate

    		 Parasite nAChR Antibiotic Infection
    Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .
    Pyrantel pamoate
  • HY-B0294
    Flubendazole
    5+ Cited Publications

    		 Parasite Microtubule/Tubulin STAT MDM-2/p53 Apoptosis Autophagy Infection Cancer
    Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites .
    Flubendazole
  • HY-15311
    Avermectin B1
    5 Publications Verification

    Abamectin; Avermectin B1a-Avermectin B1b mixt.

    		 Environmental Pollutants Antibiotic Autophagy Parasite Apoptosis Reactive Oxygen Species (ROS) Infection Inflammation/Immunology
    Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy .
    Avermectin B1
  • HY-13582
    Carbendazim
    5+ Cited Publications

    		 Environmental Pollutants Fungal Parasite Infection Cancer
    Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
    Carbendazim
  • HY-B0778
    Milbemycin oxime
    1 Publications Verification

    		 Antibiotic Parasite Infection
    Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .
    Milbemycin oxime
  • HY-B1073
    Morantel tartrate

    		Parasite Infection
    Morantel tartrate is an anthelmintic agent. Sustained-release three-layer composite tablets of Morantel tartrate are administered orally and release after exposure to rumen fluid. Morantel tartrate reduces the fecal egg output and worm burden of gastrointestinal nematodes in Hereford calves. Morantel tartrate is used in research related to gastrointestinal nematode infections .
    Morantel tartrate
  • HY-B1761R
    Santonin (Standard)

    Alpha-Santonin (Standard)

    		 Reference Standards Parasite Infection
    Santonin (Standard) is the analytical standard of Santonin. This product is intended for research and analytical applications. Santonin is an active principle of the plant Artemisia cina, which is formely used to treat worms .
    Santonin (Standard)
  • HY-15648C
    GSK-J5
    1 Publications Verification

    		 Histone Demethylase Parasite Cancer
    GSK-J5 is a potent inhibitor of Schistosome and worm. GSK-J5 increases schistosomula mortality and adult worm motility and mortality, as well as egg oviposition, in a dose- and time-dependent manner .
    GSK-J5
  • HY-13582R
    Carbendazim (Standard)
    5+ Cited Publications

    		 Parasite Fungal Reference Standards Infection Cancer
    Carbendazim (Standard) is the analytical standard of Carbendazim. This product is intended for research and analytical applications. Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
    Carbendazim (Standard)
  • HY-12640R
    Pyrantel pamoate (Standard)

    Pyrantel embonate (Standard)

    		 Reference Standards Parasite nAChR Antibiotic Infection
    Pyrantel (pamoate) (Standard) is the analytical standard of Pyrantel (pamoate). This product is intended for research and analytical applications. Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .
    Pyrantel pamoate (Standard)
  • HY-B2186
    Piperazine adipate

    		Parasite Infection
    Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.
    Piperazine adipate
  • HY-B0294R
    Flubendazole (Standard)

    		Reference Standards Parasite Microtubule/Tubulin STAT MDM-2/p53 Apoptosis Autophagy Infection Cancer
    Flubendazole (Standard) is the analytical standard of Flubendazole. This product is intended for research and analytical applications. Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites .
    Flubendazole (Standard)
  • HY-12641
    Pyrantel tartrate
    1 Publications Verification

    		 Parasite nAChR Antibiotic Infection
    Pyrantel tartrate is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel tartrate can cause spasmodic muscle paralysis in parasites. Pyrantel tartrate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .
    Pyrantel tartrate
  • HY-P1768
    Urechistachykinin I

    Uru-TK I

    		 Bacterial Infection
    Urechistachykinin I (Uru-TK I), an invertebrate tachykinin-related peptides (TRPs) isolated from echiuroid worms, shows antimicrobial activities without a hemolytic effect .
    Urechistachykinin I
  • HY-U00045
    Epsiprantel

    BRL-38705

    		 Parasite Others
    Epsiprantel (BRL-38705) is a compound with anti-Echinococcus activity that can cause the death of protoscolex, larvae and adults in vitro, and is more effective against mature worms than larvae in vivo, with no side effects.
    Epsiprantel
  • HY-121546
    ALLO-1

    		Atg8/LC3 Autophagy Cancer
    ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif .
    ALLO-1
  • HY-W098008
    Fenbendazole analog-1

    		Parasite Microtubule/Tubulin Infection
    Fenbendazole analog-1 (compound 9) is a 2-methoxycarbonylamino-derived antiparasitic compound and inhibits rat brain tubulin polymerization. Fenbendazole analog-1 inhibits the growth of the protozoa Giardia lamblia, Entamoeba histolytica, and the worm Trichinella spiralis .
    Fenbendazole analog-1
  • HY-12641A
    Pyrantel

    		nAChR Parasite Antibiotic Infection
    Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .
    Pyrantel
  • HY-118565
    Rhizocarpic acid

    		Endogenous Metabolite Bacterial Infection
    Rhizocarpic acid (Compound 2) is a secondary metabolite of lichen. Rhizocarpic acid effectively inhibits the growth of bacteria, such as Bacillus subtilis and Staphylococcus aureus, as well as murine myeloma NS-1 cells. Rhizocarpic acid is an antioxidant and an insect antifeedant with an ED50 of 71 μmol/g dry weight against neonate larvae of the Egyptian cotton leaf worm Spodoptera littoralis .
    Rhizocarpic acid
  • HY-W006672
    Dibenzo[b,e]oxepin-11(6H)-one

    		Parasite Infection
    Dibenzo[b,e]oxepin-11(6H)-one (Compound 1a) is a dibenzoxepinone derivative that exhibits significant antiparasitic activity .
    Dibenzo[b,e]oxepin-11(6H)-one
  • HY-W009681
    1-(2-Methoxyphenyl)piperazine hydrochloride

    		5-HT Receptor Serotonin Transporter Drug Intermediate Infection Neurological Disease
    1-(2-Methoxyphenyl)piperazine hydrochloride is a key agent intermediate of antipsychotics with high affinity to the serotonin receptors and 5-HT, which can be used to synthesize the intestinal worm-repellent agents Piperazine phosphate (HY-B0912C) and Piperazine citrate (HY-17599), as well as Fluphenazine (HY-119980), dihydrochloride, Rifampicin (HY-B0272) .
    1-(2-Methoxyphenyl)piperazine hydrochloride
  • HY-15311R
    Avermectin B1 (Standard)

    Abamectin (Standard); Avermectin B1a-Avermectin B1b mixt. (Standard)

    		 Reference Standards Parasite Autophagy Apoptosis Reactive Oxygen Species (ROS) Antibiotic Infection Inflammation/Immunology
    Avermectin B1 (Standard) is the analytical standard of Avermectin B1. This product is intended for research and analytical applications. Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy .
    Avermectin B1 (Standard)
  • HY-175184
    LSD1-IN-44

    		Histone Demethylase Infection
    LSD1-IN-44 (Compound 19) is a LSD1 inhibitor with an IC50 of 0.02  μM for LSD1-CoREST enzymatic complex. LSD1-IN-44 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. LSD1-IN-44 has no significant toxicity to human cells. LSD1-IN-44 can be used for schistosomiasis research .
    LSD1-IN-44
  • HY-178773
    SIRT2-IN-18

    		Sirtuin Apoptosis Infection
    SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with IC50s of 5.3  and 12.3 μM for SmSIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis .
    SIRT2-IN-18
  • HY-137007
    SMA-12b

    		Interleukin Related Others Inflammation/Immunology
    SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases .
    SMA-12b
  • HY-W158234
    N-Methylbenzo[d]oxazol-2-amine

    		Parasite Infection
    N-Methylbenzo[d]oxazol-2-amine (compound 1) is an anthelmintic activity and lower cytotoxicity against T. spiralis adult worm. N-Methylbenzo[d]oxazol-2-amine up-regulates the metabolism of purine, pyrimidine and down-regulates sphingolipid metabolism .
    N-Methylbenzo[d]oxazol-2-amine
  • HY-N12622
    AChE-IN-58

    		Cholinesterase (ChE) Neurological Disease
    AChE-IN-58 (Compound 3) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-58 can extend the mean lifespan, delay the Aβ1-42-induced paralysis, enhanc the locomotion, and alleviate glutamic acid (Glu)-induced neurotoxicity of CL4176 worms .
    AChE-IN-58
  • HY-124018
    MMV665852

    		Parasite Infection
    MMV665852 is an antischistosomal agent that inhibits worm viability in vitro. MMV665852 reduces worm burden in mice infected with Schistosoma mansoni.
    MMV665852
  • HY-B0263R
    Thiabendazole (Standard)

    Tiabendazole (Standard); 2-(4-Thiazolyl)benzimidazole (Standard)

    		 Reference Standards Mitochondrial Metabolism Parasite Infection
    Thiabendazole (Standard) is the analytical standard of Thiabendazole. This product is intended for research and analytical applications. Thiabendazole inhibits worm-specific fumarate reductase and has anthelmintic properties.
    Thiabendazole (Standard)
  • HY-126057AS
    (S)-Praziquantel-d11

    		Isotope-Labeled Compounds Others
    (S)-Praziquantel-d11 is the deuterium labeled (S)-Praziquantel. (S)-Praziquantel, a toxic enantiomerof Praziquantel, is ineffective against worms .
    (S)-Praziquantel-d11
  • HY-172356
    Biotin-PEG3700-NH2

    		Biochemical Assay Reagents Others
    Biotin-PEG-NH2 (Mn 3700) can be used for biotinylation of polymerized worm micelles for targeting and drug transfer to cells .
    Biotin-PEG3700-NH2
  • HY-B0223S
    Albendazole-d3

    SKF-62979-d3

    		 Parasite Infection
    Albendazole-d3 is the deuterium labeled Albendazole, which is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations .
    Albendazole-d3
  • HY-135410
    ABZ-amine

    Amino albendazole

    		 Drug Metabolite Infection
    ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations .
    ABZ-amine
  • HY-P1763
    Urechistachykinin II

    Uru-TK II

    		 Bacterial Infection
    Urechistachykinin II (Uru-TK II), an invertebrate tachykinin-related peptides (TRPs) isolated from echiuroid worms, shows antimicrobial activities without a hemolytic effect .
    Urechistachykinin II
  • HY-B2186R
    Piperazine adipate (Standard)

    		Reference Standards Parasite Infection
    Piperazine adipate (Standard) is the analytical standard of Piperazine adipate. This product is intended for research and analytical applications. Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.
    Piperazine adipate (Standard)
  • HY-168619
    DNA crosslinker 6

    		Parasite Infection Cancer
    DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC50=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC50 value of 0.83 µM for the inhibition of T. brucei .
    DNA crosslinker 6
  • HY-N10403R
    4-Hydroxyestradiol (Standard)

    4-Hydroxy-17β-estradiol (Standard)

    		 Reference Standards Drug Metabolite Endogenous Metabolite Cancer
    ABZ-amine (Standard) is the analytical standard of ABZ-amine. This product is intended for research and analytical applications. ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations .
    4-Hydroxyestradiol (Standard)
  • HY-135410R
    ABZ-amine (Standard)

    Amino albendazole (Standard)

    		 Drug Metabolite Reference Standards Infection
    ABZ-amine (Standard) is the analytical standard of ABZ-amine. This product is intended for research and analytical applications. ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations .
    ABZ-amine (Standard)
  • HY-151133
    Antiparasitic agent-9

    		Parasite Infection
    Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the human parasite .
    Antiparasitic agent-9
  • HY-124874
    (rel)-Asperparaline A

    (rel)-Aspergillimide; (rel)-VM55598

    		 nAChR Neurological Disease
    (rel)-Asperparaline A ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. (rel)-Asperparaline A is also a potent and selective antagonist of nAChR. (rel)-Asperparaline A exhibits paralytic activity in silk worms .
    (rel)-Asperparaline A
  • HY-178979
    PIM-IN-3

    		Parasite Infection
    PIM-IN-3 (Compound 50) is an orally active new anti-intestinal worm drug. PIM-IN-3 exhibits strong inhibitory activity in vitro, especially for whipworms (IC50 = 6.6 µM). PIM-IN-3 has low cytotoxicity. PIM-IN-3 can be used in the research of gastrointestinal nematode diseases .
    PIM-IN-3
  • HY-101258
    Cardol triene

    		Parasite Infection
    Cardol triene is a phenol found in cashew nut shell liquid that competitively and irreversibly inhibits mushroom tyrosinase (IC50=22.5 μM). It is schistosomicidal, killing 25, 75, and 100% of S. mansoni worms after 24 hours when used at concentrations of 50, 100, or 200 μM, respectively. It has been used as a starting material for the synthesis of bis-benzoxazines.
    Cardol triene
  • HY-12641R
    Pyrantel tartrate (Standard)

    		Reference Standards Parasite nAChR Antibiotic Infection
    Pyrantel (tartrate) (Standard) is the analytical standard of Pyrantel (tartrate). This product is intended for research and analytical applications. Pyrantel tartrate is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel tartrate can cause spasmodic muscle paralysis in parasites. Pyrantel tartrate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .
    Pyrantel tartrate (Standard)
  • HY-B0778R
    Milbemycin oxime (Standard)

    		Reference Standards Antibiotic Parasite Infection
    Milbemycin oxime (Standard) is the analytical standard of Milbemycin oxime. This product is intended for research and analytical applications. Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .
    Milbemycin oxime (Standard)
  • HY-144098
    HDAC8-IN-2

    		Parasite HDAC Others
    HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs .
    HDAC8-IN-2
  • HY-175185
    MC3935

    		Histone Demethylase Infection
    MC3935 is a LSD1 inhibitor with an IC50 of 0.52  μM for LSD1-CoREST enzymatic complex. MC3935 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. MC3935 has no significant toxicity to human cells. MC3935 can be used for schistosomiasis research .
    MC3935
  • HY-122522
    2-Methylcardol triene

    		Glycosidase Parasite Infection
    2-Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC50=39.6 μM). 2-Methylcardol triene is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 μM. 2-Methylcardol triene has been used as a starting material for the synthesis of mono- and bis-benzoxazines.
    2-Methylcardol triene
  • HY-N7854
    Anacardic acid diene

    Anacardic acid 15:2

    		 Bacterial Infection
    Anacardic acid diene is a polyunsaturated form of anacardic acid (HY-N2020) that has been found in cashew nut shell liquid. It has antibacterial activity against methicillin resistant S. aureus (MRSA) and S. mutans (MICs=12.5 and 6.25 μg/mL, respectively). Anacardic acid diene has schistosomicidal activity against adult S. mansoni worms when used at a concentration of 100 μM. It also inhibits soybean lipoxygenase-1 in a time-dependent manner.
    Anacardic acid diene

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