Morantel tartrate

Cat. No.: HY-B1073 Purity: 99.01%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Morantel tartrate is an anthelmintic agent. Sustained-release three-layer composite tablets of Morantel tartrate are administered orally and release after exposure to rumen fluid. Morantel tartrate reduces the fecal egg output and worm burden of gastrointestinal nematodes in Hereford calves. Morantel tartrate is used in research related to gastrointestinal nematode infections.

For research use only. We do not sell to patients.

Morantel tartrate Chemical Structure

CAS No. : 26155-31-7

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Morantel tartrate:

Morantel Get quote
Morantel tartrate (Standard) Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Parasite Isoform Specific Products:

View All Isoforms

Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

A single dose of morantel tartrate (19.8 g; in the form of sustained-release triple-layer compressed tablets of morantel tartrate) achieves steady-state concentrations in all gastrointestinal compartments and feces of Holstein steers, and these concentrations are maintained for 91 to 98 days^[1].
Morantel tartrate (9.7 mg/kg; administered 3 times to calves) reduces gastrointestinal nematode infections in calves (lowering the average fecal egg count to 36.3 e/g), and increases the body weight of dairy cows by 28.8 kg and calves by 11.1 kg under grazing conditions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Hereford (cows: similar genetic background; calves: aged 41-142 days at study start)^[2]
Dosage:	9.7 mg/kg
Administration:	bolus; 2 times (cows); 3 times (calves)
Result:	Increased average total weight gain of treated cows by 48.1 kg (average daily gain 0.38 kg) over 127 days, representing a 28.8 kg weight gain advantage over control cows (significance at 10%). Showed no significant difference in fecal nematode egg counts between treated and control cows, with an overall average of 1.2 eggs per gram (e/g) over the study period. Increased average total weight gain of treated calves by 95.8 kg (average daily gain 0.75 kg) over 127 days, representing an 11.1 kg weight gain advantage over control calves (P < .01). Reduced fecal nematode egg counts of treated calves to an overall average of 36.3 e/g over the study period (compared to 89.2 e/g for control calves), with counts significantly lower (P < .01) than control calves on all sampling dates after the first pre-treatment sampling, declining from a pre-treatment high of 54.8 e/g to 13.3 e/g in September.

Molecular Weight

370.42

Formula

C₁₆H₂₂N₂O₆S

CAS No.

26155-31-7

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=C(/C=C/C2=NCCCN2C)SC=C1.O=C(O)[C@H](O)[C@@H](O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (337.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6996 mL	13.4982 mL	26.9964 mL
5 mM	0.5399 mL	2.6996 mL	5.3993 mL
10 mM	0.2700 mL	1.3498 mL	2.6996 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.01%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (247 KB) HNMR (218 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Lanusse CE, et al. Morantel tartrate release from a long-acting intraruminal device in cattle: pharmacokinetics and gastrointestinal distribution. J Vet Pharmacol Ther. 1992;15(2):117-123. [Content Brief]

[2]. Ciordia H, et al. Effect of an anthelmintic program with morantel tartrate on the performance of beef cattle. J Anim Sci. 1982;54(6):1111-1114. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6996 mL	13.4982 mL	26.9964 mL	67.4910 mL
	5 mM	0.5399 mL	2.6996 mL	5.3993 mL	13.4982 mL
	10 mM	0.2700 mL	1.3498 mL	2.6996 mL	6.7491 mL
	15 mM	0.1800 mL	0.8999 mL	1.7998 mL	4.4994 mL
	20 mM	0.1350 mL	0.6749 mL	1.3498 mL	3.3745 mL
	25 mM	0.1080 mL	0.5399 mL	1.0799 mL	2.6996 mL
	30 mM	0.0900 mL	0.4499 mL	0.8999 mL	2.2497 mL
	40 mM	0.0675 mL	0.3375 mL	0.6749 mL	1.6873 mL
	50 mM	0.0540 mL	0.2700 mL	0.5399 mL	1.3498 mL
	60 mM	0.0450 mL	0.2250 mL	0.4499 mL	1.1248 mL
	80 mM	0.0337 mL	0.1687 mL	0.3375 mL	0.8436 mL
	100 mM	0.0270 mL	0.1350 mL	0.2700 mL	0.6749 mL