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Cat. No.: HY-156562B

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5-PT TFA

(Synonyms: 5-Propargyltryptamide TFA)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

5-PT (5-Propargyltryptamide) TFA is an alkyne-functionalized derivative of 5-HT (HY-B1473A) and serotonylation substrate that can be taken up by living cells. After conjugation with biotin, 5-PT TFA enables the identification of serotonylated proteins via copper click chemistry and mass spectrometry. 5-PT TFA can label and isolate serotonylated cells in alveolar epithelial cells for proteomic analysis. 5-PT TFA is applicable to research related to bronchopulmonary dysplasia.

For research use only. We do not sell to patients.

CAS No.: 3117303-22-4
Formula: C₁₅H₁₅F₃N₂O₃
Molecular Weight:328.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

5-PT TFA Chemical Structure

CAS No.: 3117303-22-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
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Bioz

Biological Activity

Description

In Vitro

5-PT (100 μM; 24 h) TFA labels 121 unique serotonylated proteins in MLE-12 alveolar epithelial cells, with many of these proteins linked to cellular processes and cell behavior regulation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3117303-22-4
Molecular Weight 328.29
Formula C₁₅H₁₅F₃N₂O₃
SMILES

O=C(C(F)(F)F)O.C#CCOC1=CC2=C(NC=C2CCN)C=C1
Synonyms

5-Propargyltryptamide TFA
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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iScience

5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. [Abstract]

2025 Nov 19;28(12):114120. PMID: 41438086

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cai P, Ding R, Yin C, et al.. 5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. iScience. 2025 Dec 19;28(12):114120. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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