Sirt1/2-IN-3
Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC50s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines.
For research use only. We do not sell to patients.
- CAS No.: 301313-42-8
- Formula: C17H14ClNO4S
- Molecular Weight:363.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.4 μM (SIRT1), 2.0 μM (SIRT2), 72.3 μM (SIRT3)[1]
Sirt1/2-IN-3 (compound hsa55) (5 μM; 48 h) induces apoptosis in different tumor cells, with IC50s of 6.5 μM (MV4-11), 9.2μM (MOLM-13), 27.2 μM (THP1), 17.4 μM (Jurkat), respectively[1].Sirt1/2-IN-3 (100 μM; 30 min) decreases the thermal stability of both SIRT1 and SIRT2 proteins at different temperatures, and also (25 μM, 30 μM; 6 h) increase level of the acetylated form of p53 and α-tubulin in MOLM-13 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 301313-42-8
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Molecular Weight 363.82
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Formula C17H14ClNO4S
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SMILES
O=S(NC1=CC(Cl)=C(C2=C1C=CC=C2)O)(C3=CC=C(OC)C=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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