R 1487
Based on 1 publication(s) in Google Scholar
R 1487 is an orally active and highly selective p38α mitogen-activated protein kinase inhibitor. R 1487 can be used in the study of rheumatoid arthritis.
For research use only. We do not sell to patients.
- CAS No.: 449811-92-1
- Formula: C19H18F2N4O3
- Molecular Weight:388.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) R 1487
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| THP-1 | IC50 |
0.047 μM
Compound: 2a, R1487
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Inhibition of LPS-induced TNFalpha production in human THP1 cells after 2 hrs by ELISA
Inhibition of LPS-induced TNFalpha production in human THP1 cells after 2 hrs by ELISA
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[PMID: 21375264] |
Chemical Information
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CAS No. 449811-92-1
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Molecular Weight 388.37
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Formula C19H18F2N4O3
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SMILES
O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC4CCOCC4)N=C3N1C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Dis Model Mech
A Drosophila chemical screen reveals targeting MEK and DGKa mitigates Ras-driven polarity-impaired tumour growth. [Abstract]2023 Mar 1;16(3):dmm049769. PMID: 36861754
Purity & Documentation
References
[1]. Goldstein DM, et al. Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
R 1487 Related Classifications
HY-14974 Related Classifications
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