MCH(human, mouse, rat)
Based on 1 publication(s) in Google Scholar
MCH (human, mouse, rat) is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC50 of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC50 values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) can be used in studies related to obesity, sleep disorders, and other associated conditions.
For research use only. We do not sell to patients.
- Purity: 99.40%
- CAS No.: 128315-56-0
- Formula: C105H160N30O26S4
- Molecular Weight:2386.84
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MCH(human, mouse, rat)
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Biological Activity
Binding IC50: 0.3 nM (MCH1R)IC50: 1.5 nM (MCH1R)[1]
MCH (human, mouse, rat) potently displaces the binding of [125I]Phe13-Tyr19-MCH to MCH-2R on the membranes of transfected COS-7 and CHO cells, with an IC50 of 1.5 nM[2].
MCH (human, mouse, rat) (60 min) dose-dependently activates calcium mobilization in CHO cells stably expressing human MCH-2R, with an EC50 of 0.1 nM[2].
MCH (human, mouse, rat) (30 s) induces a robust, dose-dependent intracellular calcium response in HEK293-AEQ17 cells stably expressing human MCH-2R, with an EC50 of 31 nM[2].
MCH (human, mouse, rat) (1 h) potently stimulates inositol phosphate turnover in HEK293-AEQ17 cells stably expressing human MCH-2R, with an EC50 of 2.7 nM[2].
MCH (human, mouse, rat) reduces the release of α-MSH and secretion of CART in rodent hypothalamic tissue explants, and induces the release of NPY and AgRP[3].
MCH (human, mouse, rat) induces dose-dependent GIRK currents in Xenopus laevis oocytes co-expressing SLC-1 receptors and GIRK channels[4].
MCH (human, mouse, rat) induces calcium-mediated chloride currents in Xenopus laevis oocytes expressing the SLC-1 receptor by activating the phospholipase C pathway[4].
MCH (human, mouse, rat) exerts inhibitory effects on primary cultured rat LH neurons, including reducing spontaneous firing frequency, suppressing glutamatergic synaptic transmission, and decreasing the amplitude of VDCC via a Gi/o-dependent pathway, with an IC50 of 7.84 nM, and it does not induce GIRK currents[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Levels of MCH (human, mouse, rat) are upregulated in fasted rats, leptin-deficient ob/ob obese mice, fa/fa rats, and diet-induced obese rats[2].
form of MCH (human, mouse, rat) (administered intracerebroventricularly; acute single injection; chronic infusion) exerts orexigenic effects in Wistar rats and Sprague-Dawley rats, including increased acute food intake and obesity induced by chronic infusion[3].
form of MCH (human, mouse, rat) (intracerebral/intracerebroventricular; chronic administration) increases food intake, body weight and obesity in mice, while overexpression of this substance in the lateral hypothalamus induces obesity and insulin resistance[4].
form of MCH (human, mouse, rat) (administered intracerebrally; administered intracerebroventricularly; administered locally in the hypothalamus; acutely administered) stimulates food intake in rats[4].
MCH (human, mouse, rat) regulates memory retention in rats[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 128315-56-0
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Appearance Solid
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Molecular Weight 2386.84
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Formula C105H160N30O26S4
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Color White to off-white
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Synonyms
Melanin-concentrating hormone(human, mouse, rat)
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Sequence Shortening
DFDMLRCMLGRVYRPCWQV (Disulfide bridge:Cys7-Cys16)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Targeting MCH Neuroendocrine Circuit in Lateral Hypothalamus to Protect Against Skeletal Senescence. [Abstract]2024 Nov;11(43):e2309951. PMID: 39320347
Solvent & Solubility
DMSO : 50 mg/mL (20.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Diniz GB, et al. The Melanin-Concentrating Hormone (MCH) System: A Tale of Two Peptides. Front Neurosci. 2019;13:1280. Published 2019 Nov 26. [Content Brief]
[2]. A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9. [Content Brief]
[3]. Griffond B, et al. MCH and feeding behavior-interaction with peptidic network. Peptides. 2009;30(11):2045-2051. [Content Brief]
[4]. Gao XB, et al. Electrophysiological effects of MCH on neurons in the hypothalamus. Peptides. 2009;30(11):2025-2030. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4190 mL | 2.0948 mL | 4.1896 mL | 10.4741 mL |
| 5 mM | 0.0838 mL | 0.4190 mL | 0.8379 mL | 2.0948 mL | |
| 10 mM | 0.0419 mL | 0.2095 mL | 0.4190 mL | 1.0474 mL | |
| 15 mM | 0.0279 mL | 0.1397 mL | 0.2793 mL | 0.6983 mL | |
| 20 mM | 0.0209 mL | 0.1047 mL | 0.2095 mL | 0.5237 mL |
MCH(human, mouse, rat) Related Classifications
HY-P1205 Related Classifications
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