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Cat. No.: HY-N21842

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Vincapusine

Vincapusine is an inhibitor of CaV3.1 calcium channel, with a IC₅₀ of 11.83 μM against the human target. Vincapusine suppresses the functional activity of the CaV3.1 calcium channel. Vincapusine exerts antihypertensive activity by inhibiting the CaV3.1 calcium channel. Vincapusine is used in hypertension-related research.

For research use only. We do not sell to patients.

CAS No.: 80248-97-1
Formula: C₂₁H₂₄N₂O₄
Molecular Weight:368.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Vincapusine Chemical Structure

CAS No.: 80248-97-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

CaV3.1

11.83 μM (IC₅₀)

All Calcium Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC50	11.83 μM	Inhibition of CaV3.1 calcium channels in transiently transfected HEK-293 cells. Inhibition of CaV3.1 calcium channels in transiently transfected HEK-293 cells.	36017978

In Vitro

Vincapusine inhibits CaV3.1 calcium channels in transiently transfected HEK-293 cells with an IC₅₀ of 11.83 μM, indicating potential antihypertensive activity via modulation of pacemaker cell calcium currents^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 80248-97-1
Molecular Weight 368.43
Formula C₂₁H₂₄N₂O₄
SMILES

CC[C@]12[C@@]3([H])C4=C5CCN3C[C@H](O)[C@@]1([H])O[C@](C(OC)=O)(C2)N4C6=CC=CC=C56
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Calderon-Rivera A, et al. Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels. Channels (Austin, Tex.). 2022 Dec;16(1):198-215.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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