1. Stem Cell/Wnt
  2. β-catenin
  3. Wnt/β-catenin agonist 3

Wnt/β-catenin agonist 3 

Cat. No.: HY-148055
Handling Instructions

Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis.

For research use only. We do not sell to patients.

Wnt/β-catenin agonist 3 Chemical Structure

Wnt/β-catenin agonist 3 Chemical Structure

CAS No. : 912790-59-1

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Description

Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis[1].

In Vitro

Wnt/β-catenin agonist 3 (compound 98; 24 h; HEK293 and SW480 cells) has 54% cell activity at 120 μM concentration compared with the positive control group LiCl (20mM)[1].
Wnt/β-catenin agonist 3 (30 and 60 μM; 24 h; HEK293 cells) is an activator for β-Catenin and deposits β-catenin[1].
Wnt/β-catenin agonist 3 (11 μM; 4 d) induces differentiation of ST2 cell line into osteoblasts and calcium deposition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 30 and 60 μM
Incubation Time: 24 hours
Result: Deposited β-catenin in a dose-dependent pattern within cells.
Molecular Weight

330.77

Formula

C16H15ClN4O2

CAS No.
SMILES

O=C(C1=NOC(C2=CC=C(Cl)C=C2)=C1)NCCCN3C=CN=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (755.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0232 mL 15.1162 mL 30.2325 mL
5 mM 0.6046 mL 3.0232 mL 6.0465 mL
10 mM 0.3023 mL 1.5116 mL 3.0232 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Product Name:
Wnt/β-catenin agonist 3
Cat. No.:
HY-148055
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