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Cat. No.: HY-188081

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YH-36400

YH-36400 is an orally bioavailable inhibitor of HIF-1α and HIF-2α. YH-36400 disrupts the dimerization of HIF-1α and HIF-1β and triggers proteasomal degradation, thereby inhibiting the transcriptional activities of HIF-1 and HIF-2. YH-36400 reduces the expression of PD-L1 and CD73, reprograms the tumor immune microenvironment, inhibits angiogenesis, and can be used in combination with immune checkpoint blockade therapy. YH-36400 is applicable to research related to breast cancer, lung cancer, melanoma, pancreatic cancer, colorectal cancer, prostate cancer, and head and neck squamous cell carcinoma.

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CAS No.: 3112733-78-2
Formule: C₂₇H₃₈N₆S₂
Masse moléculaire:510.76

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Please store the product under the recommended conditions in the Certificate of Analysis.

YH-36400 Chemical Structure

CAS No.: 3112733-78-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform HIF/HIF Prolyl-Hydroxylase :

In Vivo

SS1.21 (i.p.; twice daily; 5 days) inhibits human colorectal tumor growth in nude mice by reducing HIF-1α and HIF-2α protein levels without causing detectable toxicity^[1].
SS1.21 is as effective as oxaliplatin at inhibiting human colorectal tumor growth in nude mice, and combination therapy enhances efficacy without increased toxicity relative to oxaliplatin alone^[1].
SS1.21 inhibits mouse colorectal tumor growth in immunocompetent mice by reducing HIF-1α protein levels and impairing tumor vascularization without causing detectable toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3112733-78-2
Masse moléculaire 510.76
Formule C₂₇H₃₈N₆S₂
SMILES

S=C(N1CCC(CCCC2CCN(C(NCC3=CC=NC=C3)=S)CC2)CC1)NCC4=CC=NC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Gregg L Semenza, et al. Direct-binding dual inhibitors of hypoxia-inducible factor 1 (hif-1) and hif-2. WO2026006342A1. 2025-06-24.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- In Vivo
Chemical Information
Pureté et documentation
Références

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YH-36400

Voir tous les produits spécifiques à Isoform HIF/HIF Prolyl-Hydroxylase