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Cat. No.: HY-187141

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1,1,2-Triphenylhex-1-ene

1,1,2-Triphenylhex-1-ene is an orally active COX-2 inhibitor with an IC₅₀ of 7.9 μM against ovine COX-2. 1,1,2-Triphenylhex-1-ene attenuates inflammation by inhibiting COX-2. 1,1,2-Triphenylhex-1-ene relieves abdominal contractions. 1,1,2-Triphenylhex-1-ene can be used in research related to inflammation and pain.

For research use only. We do not sell to patients.

CAS No.: 69052-92-2
Formula: C₂₄H₂₄
Molecular Weight:312.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

1,1,2-Triphenylhex-1-ene Chemical Structure

CAS No.: 69052-92-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

Ovine COX-2

7.9 μM (IC₅₀)

All COX Isoforms :

In Vitro

1,1,2-Triphenylhex-1-ene (Compound 14) (0.01-100 μM; 5 min pre-incubation, 2 min reaction) acts as a weakly selective inhibitor of ovine COX-2, with an IC₅₀ of 7.9 μM and a selectivity index >12; it shows no inhibitory effect on ovine COX-1 even at concentrations as high as 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

1,1,2-Triphenylhex-1-ene (0.5-30 mg/kg; p.o.; single administration) exhibits moderate in vivo anti-inflammatory activity in the carrageenan-induced rat paw edema model, with an ID₅₀ of 22.3 mg/kg^[1].
1,1,2-Triphenylhex-1-ene (5 mg/kg; p.o.; single administration) exhibits in vivo analgesic activity, producing 55.5% and 44.4% inhibition of NaCl-induced abdominal constriction in rats at 30 min and 1 h after oral administration at 5 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, 100-110 g)^[1]
Dosage:

0.5-30 mg/kg
Administration:

p.o.; single dose
Result:

Achieved an ID₅₀ of 22.3 mg/kg for inhibition of paw edema at 3 hours.

Animal Model:

Sprague-Dawley (male)^[1]
Dosage:

5 mg/kg
Administration:

p.o.; single dose
Result:

Caused 55.5% inhibition of abdominal constrictions at 30 minutes post-administration.
Caused 44.4% inhibition of abdominal constrictions at 1 hour post-administration.

Chemical Information

CAS No. 69052-92-2
Molecular Weight 312.46
Formula C₂₄H₂₄
SMILES

C=1C=CC(=CC1)C(C=2C=CC=CC2)=C(C=3C=CC=CC3)CCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Uddin MJ, et al. Design and synthesis of acyclic triaryl (Z)-olefins: a novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorganic & medicinal chemistry. 2004 Nov 15;12(22):5929-40.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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1,1,2-Triphenylhex-1-ene

All COX Isoforms