1,3-Diphenylguanidine
Based on 1 publication(s) in Google Scholar
1,3-Diphenylguanidine is a widely used accelerator in rubber vulcanization. 1,3-Diphenylguanidine increases ROS activity and decreases SOD and CAT activity. 1,3-Diphenylguanidine accelerates the vulcanization process. 1,3-Diphenylguanidine impairs the reproduction and growth of Moina macrocopa[1] [2] [3] .
For research use only. We do not sell to patients.
- Purity : 99.76%
- CAS No.: 102-06-7
- Formula: C13H13N3
- Molecular Weight:211.27
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-W014332R
1,3-Diphenylguanidine (Standard)Standard Of 1,3-Diphenylguanidine -
HY-17471A
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Publications Citing Use of MedChemExpress (MCE) 1,3-Diphenylguanidine
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Biological Activity
Description
In Vitro
1,3-Diphenylguanidine (0.5 mg/L) increases ROS activity, decreases activities of SOD and CAT in Moina macrocopa, along with impaired reproduction and growth[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 102-06-7
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Appearance Solid
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Molecular Weight 211.27
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Formula C13H13N3
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Color White to off-white
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SMILES
N=C(NC1=CC=CC=C1)NC2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (473.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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ROS/oxidative-stress fluorescent staining
ROS/oxidative-stress fluorescent staining uses cell-permeant fluorogenic probes that become fluorescent after oxidation inside cells or tissues; commonly used examples include DCFH-DA/DCFDA for broad cellular oxidant detection, DHE for superoxide-related signal detection, MitoSOX for mitochondrial superoxide-related signal detection, and CellROX probes for oxidative-stress-associated fluorescence readouts. The assay detects probe oxidation rather than a single ROS species unless the probe and analysis method have been chemically validated for that species. DCFH-DA enters cells, is deacetylated by intracellular esterases to DCFH, and produces fluorescent DCF after oxidation, so the readout is used as an operational measure of total cellular oxidative stress rather than a species-specific ROS measurement. DHE and MitoSOX can report superoxide-related oxidation, but red fluorescence alone can include non-specific ethidium-like oxidation products; HPLC or optimized spectral approaches are
Purity & Documentation
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Data Sheet (272 KB)
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SDS (789 KB)
- English - EN (789 KB)
- Français - FR (789 KB)
- Deutsch - DE (789 KB)
- Norwegian - NO (789 KB)
- Español - ES (789 KB)
- Swedish - SV (789 KB)
- Italian - IT (789 KB)
- Korean - KR (789 KB)
- Portuguese - PT (789 KB)
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Handling Instructions (2659 KB)
References
[1]. Ann Pontén, et al. Occupational allergic contact dermatitis caused by sterile non-latex protective gloves: clinical investigation and chemical analyses. Contact Dermatitis. 2013 Feb;68(2):103-10 [Content Brief]
[3]. Koëter HB, et al. Effect of oral administration of 1,3-diphenylguanidine on sperm morphology and male fertility in mice. Toxicology. 1992;71(1-2):173-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.7333 mL | 23.6664 mL | 47.3328 mL | 118.3320 mL |
| 5 mM | 0.9467 mL | 4.7333 mL | 9.4666 mL | 23.6664 mL | |
| 10 mM | 0.4733 mL | 2.3666 mL | 4.7333 mL | 11.8332 mL | |
| 15 mM | 0.3156 mL | 1.5778 mL | 3.1555 mL | 7.8888 mL | |
| 20 mM | 0.2367 mL | 1.1833 mL | 2.3666 mL | 5.9166 mL | |
| 25 mM | 0.1893 mL | 0.9467 mL | 1.8933 mL | 4.7333 mL | |
| 30 mM | 0.1578 mL | 0.7889 mL | 1.5778 mL | 3.9444 mL | |
| 40 mM | 0.1183 mL | 0.5917 mL | 1.1833 mL | 2.9583 mL | |
| 50 mM | 0.0947 mL | 0.4733 mL | 0.9467 mL | 2.3666 mL | |
| 60 mM | 0.0789 mL | 0.3944 mL | 0.7889 mL | 1.9722 mL | |
| 80 mM | 0.0592 mL | 0.2958 mL | 0.5917 mL | 1.4791 mL | |
| 100 mM | 0.0473 mL | 0.2367 mL | 0.4733 mL | 1.1833 mL |
1,3-Diphenylguanidine Related Classifications
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