1,4-Diazabicyclo[2.2.2]octane
Based on 1 publication(s) in Google Scholar
1,4-Diazabicyclo[2.2.2]octane is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 280-57-9
- Formula: C6H12N2
- Molecular Weight:112.18
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Storage:
RT, protect from light, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
![1,4-Diazabicyclo[2.2.2]octane Chemical Structure](https://file.medchemexpress.com/product_pic/hy-y0566.gif "Click to View 1,4-Diazabicyclo[2.2.2]octane Chemical Structure")
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 1,4-Diazabicyclo[2.2.2]octane
More
Biological Activity
1,4-Diazabicyclo[2.2.2]octane is used as polyurethane catalyst, Balis-Hillman reaction catalyst complexing ligand and lewis base. It finds use in dye lasers and in mounting samples for fluorescence microscopy and as anti-fade reagent shown to sca Venge free radicals due to flurochrome excitation of fluorochromes. Furthermore, it is an oxidation and polymerization catalyst.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 280-57-9
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Appearance Solid
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Molecular Weight 112.18
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Formula C6H12N2
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Color White to off-white
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SMILES
N1(CC2)CCN2CC1
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Synonyms
Triethylenediamine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, protect from light, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
Publications (1)
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Journal Impact Factor
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Most Recent
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J Integr Neurosci
Long-Range Projections of Cortical GABAergic Neurons to the Midline Dorsal Thalamic Nuclei in GAD67-GFP Mice. [Abstract]2025 Dec 26;24(12):47187. PMID: 41503986
Solvent & Solubility
DMSO : 100 mg/mL (891.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (22.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (22.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (248 KB)
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SDS (766 KB)
- English - EN (766 KB)
- Français - FR (766 KB)
- Deutsch - DE (766 KB)
- Norwegian - NO (766 KB)
- Español - ES (766 KB)
- Swedish - SV (766 KB)
- Italian - IT (766 KB)
- Korean - KR (766 KB)
- Portuguese - PT (766 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.9142 mL | 44.5712 mL | 89.1424 mL | 222.8561 mL |
| 5 mM | 1.7828 mL | 8.9142 mL | 17.8285 mL | 44.5712 mL | |
| 10 mM | 0.8914 mL | 4.4571 mL | 8.9142 mL | 22.2856 mL | |
| 15 mM | 0.5943 mL | 2.9714 mL | 5.9428 mL | 14.8571 mL | |
| 20 mM | 0.4457 mL | 2.2286 mL | 4.4571 mL | 11.1428 mL | |
| 25 mM | 0.3566 mL | 1.7828 mL | 3.5657 mL | 8.9142 mL | |
| 30 mM | 0.2971 mL | 1.4857 mL | 2.9714 mL | 7.4285 mL | |
| 40 mM | 0.2229 mL | 1.1143 mL | 2.2286 mL | 5.5714 mL | |
| 50 mM | 0.1783 mL | 0.8914 mL | 1.7828 mL | 4.4571 mL | |
| 60 mM | 0.1486 mL | 0.7429 mL | 1.4857 mL | 3.7143 mL | |
| 80 mM | 0.1114 mL | 0.5571 mL | 1.1143 mL | 2.7857 mL | |
| 100 mM | 0.0891 mL | 0.4457 mL | 0.8914 mL | 2.2286 mL |
1,4-Diazabicyclo[2.2.2]octane Related Classifications
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