2',2'-Difluorodeoxyuridine 5'-monophosphate
2',2'-Difluorodeoxyuridine 5'-monophosphate (dFdUMP) is a metabolite of Gemcitabine (HY-17026) and an inhibitor of Thymidylate synthase, with an inhibition constant of 130 μM. 2',2'-Difluorodeoxyuridine 5'-monophosphate can be used in research related to ovarian cancer, hematologic malignancies, non-small cell lung cancer, pancreatic cancer, soft tissue sarcoma, and glioblastoma multiforme.
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- CAS. Nr.: 139729-89-8
- Formel: C9H11F2N2O8P
- Molecular Weight:344.16
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
2',2'-Difluorodeoxyuridine 5'-monophosphate inhibits thymidylate synthase with an inhibitory constant of 130 μM, resulting in increased dUMP mis-incorporation into DNA, though it is far less potent than 5-fluorodeoxyuridine monophosphate in tumour cell line assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 139729-89-8
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Molecular Weight 344.16
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Formel C9H11F2N2O8P
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SMILES
O=C(C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](COP(O)(O)=O)O2)NC1=O
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Synonyms
dFdUMP
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Derissen EJB, et al. Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides. British journal of clinical pharmacology. 2018 Jun;84(6):1279-1289. [Content Brief]
[2]. Jansen RS, et al. Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2009 Oct;23(19):3040-50. [Content Brief]
[3]. Rizzuto I, et al. Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate. Pharmacogenomics. 2017 Jun;18(9):911-925. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
2',2'-Difluorodeoxyuridine 5'-monophosphate Related Classifications
HY-185841 Related Classifications
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Keywords
- 2',2'-Difluorodeoxyuridine 5'-monophosphate
- 139729-89-8
- dFdUMP
- Drug Metabolite
- Thymidylate Synthase
- deoxyuridine monophosphate
- DNA
- solid tumors
- pancreatic cancer
- hematological malignancies
- non-small-cell lung cancer
- ovarian cancer
- soft tissue sarcoma
- thymidylate synthase
- glioblastoma multiforme
- Inhibitor
- inhibitor
- inhibit