139729-89-8
139729-89-8
Chemical Structure
2',2'-Difluorodeoxyuridine 5'-monophosphate
Synonym(s): dFdUMP
- CAS No.: 139729-89-8
- Formula:C9H11F2N2O8P
- Molecular Weight:344.16
InChIKey: APSMIPKDENVCML-QPPQHZFASA-N
SMILES: O=C(C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](COP(O)(O)=O)O2)NC1=O
Biological Activity: 2',2'-Difluorodeoxyuridine 5'-monophosphate (dFdUMP) is a metabolite of Gemcitabine (HY-17026) and an inhibitor of Thymidylate synthase, with an inhibition constant of 130 μM. 2',2'-Difluorodeoxyuridine 5'-monophosphate can be used in research related to ovarian cancer, hematologic malignancies, non-small cell lung cancer, pancreatic cancer, soft tissue sarcoma, and glioblastoma multiforme[1][2][3].
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2',2'-Difluorodeoxyuridine 5'-monophosphate | 2',2'-Difluorodeoxyuridine 5'-monophosphate (dFdUMP) is a metabolite of Gemcitabine (HY-17026) and an inhibitor of Thymidylate synthase, with an inhibition constant of 130 μM. 2',2'-Difluorodeoxyuridine 5'-monophosphate can be used in research related to ovarian cancer, hematologic malignancies, non-small cell lung cancer, pancreatic cancer, soft tissue sarcoma, and glioblastoma multiforme. | |||||||||||||||||||||
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References
- [1]. Derissen EJB, et al. Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides. British journal of clinical pharmacology. 2018 Jun;84(6):1279-1289. [Content Brief]
- [2]. Jansen RS, et al. Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2009 Oct;23(19):3040-50. [Content Brief]
- [3]. Rizzuto I, et al. Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate. Pharmacogenomics. 2017 Jun;18(9):911-925. [Content Brief]
